Crit Care Med:感染甲型H7N9病毒的住院患者心脏损伤与死亡率之间的关联

2020-01-16 xing.T MedSci原创

由此可见,在感染了甲型流感病毒(H7N9)的住院患者中,心脏损伤是一种常见病,并且与更高的死亡风险相关。

近日,危重病医学领域权威杂志Critical Care Medicine上发表了一篇研究文章,研究人员旨在评估住院的感染了甲型禽流感(H7N9)病毒的患者心脏损伤患病率及其与死亡率之间的关系。

该研究于2015年1月22日至2017年6月16日期间在中国大陆17个省、自治区和直辖市的133家收治了感染H7N9病毒患者的医院中进行了一项回顾性队列研究。最终分析共纳入了321例甲型H7N9病毒感染患者。

研究人员从医疗记录中收集了人口统计学和临床​特征。根据心脏生物标志物、心电图或超声心动图结果来定义心脏损伤。在321名患者中,有203名(63.2%)患者表现出心脏损伤的迹象。与未受伤组相比,心脏损伤组的PaO2/FIO2较低(中位数为102.0 vs. 148.4 mmHg; p<0.001),急性生理和慢性健康评估II评分较高(中位数为17.0 vs. 11.0; p<0.001),住院时间更长(10.0 vs. 9.0 d; p=0.029),院内死亡比例更高(64.0% vs. 20.3%;p<0.001)。在心脏损伤组中直至出院或死亡的病毒清除率要低于未损伤组(58.6% vs. 86.4%;p<0.001)。多变量调整的Cox比例风险回归分析表明,住院期间心脏损伤与较高的死亡率相关(风险比为2.06;95%CI为1.33-3.24)。

由此可见,在感染了甲型流感病毒(H7N9)的住院患者中,心脏损伤是一种常见病,并且与更高的死亡风险相关。

原始出处:

Gao, Chang.et al.Association Between Cardiac Injury and Mortality in Hospitalized Patients Infected With Avian Influenza A (H7N9) Virus.critical care medicine.2020.https://journals.lww.com/ccmjournal/Abstract/onlinefirst/Association_Between_Cardiac_Injury_and_Mortality.95743.aspx

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