盘点:2019年3月9日BMJ研究精选

2019-03-11 zhangfan MedSci原创

BMJ

2019年3月9日BMJ研究精选



【1】内源性睾酮含量与血栓、心力衰竭以及心肌梗塞风险


近日研究人员就内源性睾酮含量与血栓栓塞、心力衰竭和心肌梗死之间的关系进行了考察

研究人员考察REDUCE研究、UK Biobank以及CARDIoGRAMplusC4D 1000 Genomes研究参与者数据,以CARDIoGRAMplusC4D 1000 Genomes研究参与者为验证组。研究的主要终点为血栓、心力衰竭以及心肌梗死。在男性中,内源性睾酮相关基因JMJD1C变异与血栓(睾酮含量每增加1个log单位的风险比值比为2.09)和心力衰竭(7.81)风险相关,但与心肌梗死的相关性较低。女性人群该相关性不显著。在验证研究中,因JMJD1C基因变异导致的内源性睾酮含量增加与心肌梗塞呈正相关(1.37)。

【2】绝经后激素治疗与阿尔茨海默病的风险


近日研究人员就阿尔茨海默病与绝经后妇女激素治疗的关系进行了考察

研究发现全身激素治疗导致阿尔茨海默病风险增加9-17%,使用雌二醇、雌激素以及孕激素患者之间的风险差异不显著。使用雌激素-孕激素的风险,与孕激素种类(醋酸炔诺酮、醋酸甲羟孕酮或其他孕激素)无关;使用时间10年以上人群的风险进一步增加,但开始全身激素治疗的年龄不是阿尔茨海默病风险增加的决定性因素。特殊的给药方法,如阴道雌二醇不增加患者疾病的风险。

【3】枪击管理与美国大规模枪击事件


近日研究人员就美国放开国家枪支限制性和枪支所有权与大规模枪击事件的关系进行了考察。回归分析发现,国家枪支放任率每增加10个单位导致大规模枪击事件发生率提高11.5%,国家枪支拥有量增加10%导致大规模枪击事件的发生率上升35.1%(从12.7%上升到 62.7%)有关。开放枪支限制,导致家庭内部与非家庭枪击事件的发生率均显著增加。

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  1. [GetPortalCommentsPageByObjectIdResponse(id=1848702, encodeId=5ae11848e02f7, content=<a href='/topic/show?id=2977356edc' target=_blank style='color:#2F92EE;'>#BMJ#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3567, encryptionId=2977356edc, topicName=BMJ)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=148754, createdName=gaoxiaoe, createdTime=Tue Dec 31 20:49:00 CST 2019, time=2019-12-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=364047, encodeId=3a9836404e4e, content=很好的学习机会, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2018/04/12/cd30eefc465f70dc4dad89bd57479781.jpg, createdBy=02be2318568, createdName=一天没事干, createdTime=Wed Apr 03 08:27:18 CST 2019, time=2019-04-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=362508, encodeId=70d73625086c, content=谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4b972455532, createdName=1240394fm61暂无昵称, createdTime=Tue Mar 12 08:52:35 CST 2019, time=2019-03-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=362469, encodeId=bada362469d0, content=学习了,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7c592194322, createdName=1209e435m98(暂无昵称), createdTime=Mon Mar 11 20:36:14 CST 2019, time=2019-03-11, status=1, ipAttribution=)]
    2019-12-31 gaoxiaoe
  2. [GetPortalCommentsPageByObjectIdResponse(id=1848702, encodeId=5ae11848e02f7, content=<a href='/topic/show?id=2977356edc' target=_blank style='color:#2F92EE;'>#BMJ#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3567, encryptionId=2977356edc, topicName=BMJ)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=148754, createdName=gaoxiaoe, createdTime=Tue Dec 31 20:49:00 CST 2019, time=2019-12-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=364047, encodeId=3a9836404e4e, content=很好的学习机会, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2018/04/12/cd30eefc465f70dc4dad89bd57479781.jpg, createdBy=02be2318568, createdName=一天没事干, createdTime=Wed Apr 03 08:27:18 CST 2019, time=2019-04-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=362508, encodeId=70d73625086c, content=谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4b972455532, createdName=1240394fm61暂无昵称, createdTime=Tue Mar 12 08:52:35 CST 2019, time=2019-03-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=362469, encodeId=bada362469d0, content=学习了,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7c592194322, createdName=1209e435m98(暂无昵称), createdTime=Mon Mar 11 20:36:14 CST 2019, time=2019-03-11, status=1, ipAttribution=)]
    2019-04-03 一天没事干

    很好的学习机会

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=1848702, encodeId=5ae11848e02f7, content=<a href='/topic/show?id=2977356edc' target=_blank style='color:#2F92EE;'>#BMJ#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3567, encryptionId=2977356edc, topicName=BMJ)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=148754, createdName=gaoxiaoe, createdTime=Tue Dec 31 20:49:00 CST 2019, time=2019-12-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=364047, encodeId=3a9836404e4e, content=很好的学习机会, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2018/04/12/cd30eefc465f70dc4dad89bd57479781.jpg, createdBy=02be2318568, createdName=一天没事干, createdTime=Wed Apr 03 08:27:18 CST 2019, time=2019-04-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=362508, encodeId=70d73625086c, content=谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4b972455532, createdName=1240394fm61暂无昵称, createdTime=Tue Mar 12 08:52:35 CST 2019, time=2019-03-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=362469, encodeId=bada362469d0, content=学习了,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7c592194322, createdName=1209e435m98(暂无昵称), createdTime=Mon Mar 11 20:36:14 CST 2019, time=2019-03-11, status=1, ipAttribution=)]
    2019-03-12 1240394fm61暂无昵称

    谢谢分享

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=1848702, encodeId=5ae11848e02f7, content=<a href='/topic/show?id=2977356edc' target=_blank style='color:#2F92EE;'>#BMJ#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3567, encryptionId=2977356edc, topicName=BMJ)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=148754, createdName=gaoxiaoe, createdTime=Tue Dec 31 20:49:00 CST 2019, time=2019-12-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=364047, encodeId=3a9836404e4e, content=很好的学习机会, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2018/04/12/cd30eefc465f70dc4dad89bd57479781.jpg, createdBy=02be2318568, createdName=一天没事干, createdTime=Wed Apr 03 08:27:18 CST 2019, time=2019-04-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=362508, encodeId=70d73625086c, content=谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4b972455532, createdName=1240394fm61暂无昵称, createdTime=Tue Mar 12 08:52:35 CST 2019, time=2019-03-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=362469, encodeId=bada362469d0, content=学习了,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7c592194322, createdName=1209e435m98(暂无昵称), createdTime=Mon Mar 11 20:36:14 CST 2019, time=2019-03-11, status=1, ipAttribution=)]
    2019-03-11 1209e435m98(暂无昵称)

    学习了,谢谢分享

    0

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