p38α抑制剂Neflamapimod治疗路易体痴呆症的II期临床成功,患者认知显着提高

2020-10-10 MedSci原创 MedSci原创

EIP制药公司的中枢神经系统疾病药物Neflamapimod(VX745)治疗轻度至中度路易体(DLB)痴呆症,患者认知能力显着改善。

在阿尔茨海默氏病第13届临床试验(CTAD)会议上,EIP制药公司宣布其中枢神经系统疾病药物Neflamapimod(VX745)治疗轻度至中度路易体痴呆(DLB)患者,II期试验达到了主要终点。根据成套神经心理测试(NTB)评估显示,每天接受3次Neflamapimod治疗的患者认知能力显着改善。此外,多个次要临床终点也获得了统计学上的显着改善。

Positive Phase II results for CNS drug neflamapimod

在双盲安慰剂对照的AscenD-LB研究中,91例患者按1:1随机分配接受40mg Neflamapimod胶囊或安慰剂治疗。接受Neflamapimod治疗的患者与安慰剂组患者相比,认知能力显着提高,并且耐受良好。

根据II期研究结果,该公司计划将neflamapimod的开发推进到III期临床。

图片来源:https://www.mdpi.com/1422-0067/21/15/5485/htm

Neflamapimod是一种小分子药物,可穿透大脑并抑制细胞内酶p38 MAP kinase α(p38α)。P38α在压力和疾病条件下于神经元中表达,已知在炎症诱导的突触毒性中起主要作用,导致突触功能受损。突触功能障碍可以引起多种中枢神经系统疾病(包括DLB和阿尔茨海默氏病)的认知功能缺陷。

Neflamapimod作为DLB的治疗药物于2019年11月获得美国食品和药物管理局(FDA)的快速通道认证。

原始出处:

https://www.europeanpharmaceuticalreview.com/news/129823/positive-phase-ii-results-for-cns-drug-neflamapimod/

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    2021-07-27 longerg
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    2021-06-05 Boyinsh
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    2021-07-22 DEXTER3139
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encryptionId=f0ed106e342, topicName=LAMA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=85aa264, createdName=redcrab, createdTime=Thu Apr 29 07:39:28 CST 2021, time=2021-04-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1764203, encodeId=bf9f1e642038d, content=<a href='/topic/show?id=90079314208' target=_blank style='color:#2F92EE;'>#路易体痴呆症#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=93142, encryptionId=90079314208, topicName=路易体痴呆症)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=78a737641523, createdName=12498b3em20(暂无昵称), createdTime=Sun Aug 22 06:39:28 CST 2021, time=2021-08-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1653103, encodeId=52ad165310389, content=<a href='/topic/show?id=5b011018e07' target=_blank style='color:#2F92EE;'>#I期临床#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10187, encryptionId=5b011018e07, topicName=I期临床)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=fc1f24335670, createdName=医生2402, createdTime=Sun Mar 07 13:39:28 CST 2021, time=2021-03-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2057692, encodeId=7389205e69257, content=<a href='/topic/show?id=c02b106e29a' target=_blank style='color:#2F92EE;'>#LAM#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10672, encryptionId=c02b106e29a, topicName=LAM)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=04ce158, createdName=lxg951, createdTime=Mon May 03 13:39:28 CST 2021, time=2021-05-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1852505, encodeId=6bb81852505c1, content=<a href='/topic/show?id=f0a254918f0' target=_blank style='color:#2F92EE;'>#抑制剂#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54918, encryptionId=f0a254918f0, topicName=抑制剂)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=44a360, createdName=jklm09, createdTime=Mon Nov 02 09:39:28 CST 2020, time=2020-11-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1524877, encodeId=05a115248e73b, content=<a href='/topic/show?id=4ba395994d' target=_blank style='color:#2F92EE;'>#II期临床#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9599, encryptionId=4ba395994d, topicName=II期临床)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=139811614978, createdName=guihongzh, createdTime=Mon Oct 12 12:39:28 CST 2020, time=2020-10-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=891187, encodeId=7d8d89118e51, content=棒棒哒,加油, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=75c55424163, createdName=ms9000001186008086, createdTime=Sun Oct 11 01:05:29 CST 2020, time=2020-10-11, status=1, ipAttribution=)]
    2021-04-29 redcrab
  5. [GetPortalCommentsPageByObjectIdResponse(id=1754942, encodeId=cabb1e549422e, content=<a href='/topic/show?id=bf6093140d4' target=_blank style='color:#2F92EE;'>#路易体#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=93140, encryptionId=bf6093140d4, topicName=路易体)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=576436807451, createdName=longerg, createdTime=Tue Jul 27 10:39:28 CST 2021, time=2021-07-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1836234, encodeId=0fa41836234ed, content=<a href='/topic/show?id=4613e1212fc' target=_blank style='color:#2F92EE;'>#痴呆症#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71212, encryptionId=4613e1212fc, topicName=痴呆症)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=726030, createdName=Boyinsh, createdTime=Sat Jun 05 20:39:28 CST 2021, time=2021-06-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2086564, encodeId=04952086564e2, content=<a href='/topic/show?id=424613621d3' target=_blank style='color:#2F92EE;'>#p38α#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13621, encryptionId=424613621d3, topicName=p38α)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6c32257, createdName=DEXTER3139, createdTime=Thu Jul 22 02:39:28 CST 2021, time=2021-07-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2011755, encodeId=d6722011e5593, content=<a href='/topic/show?id=f0ed106e342' target=_blank style='color:#2F92EE;'>#LAMA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10673, encryptionId=f0ed106e342, topicName=LAMA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=85aa264, createdName=redcrab, createdTime=Thu Apr 29 07:39:28 CST 2021, time=2021-04-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1764203, encodeId=bf9f1e642038d, content=<a href='/topic/show?id=90079314208' target=_blank style='color:#2F92EE;'>#路易体痴呆症#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=93142, encryptionId=90079314208, topicName=路易体痴呆症)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=78a737641523, createdName=12498b3em20(暂无昵称), createdTime=Sun Aug 22 06:39:28 CST 2021, time=2021-08-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1653103, encodeId=52ad165310389, content=<a href='/topic/show?id=5b011018e07' target=_blank style='color:#2F92EE;'>#I期临床#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10187, encryptionId=5b011018e07, topicName=I期临床)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=fc1f24335670, createdName=医生2402, createdTime=Sun Mar 07 13:39:28 CST 2021, time=2021-03-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2057692, encodeId=7389205e69257, content=<a href='/topic/show?id=c02b106e29a' target=_blank style='color:#2F92EE;'>#LAM#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10672, encryptionId=c02b106e29a, topicName=LAM)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=04ce158, createdName=lxg951, createdTime=Mon May 03 13:39:28 CST 2021, time=2021-05-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1852505, encodeId=6bb81852505c1, content=<a href='/topic/show?id=f0a254918f0' target=_blank style='color:#2F92EE;'>#抑制剂#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54918, encryptionId=f0a254918f0, topicName=抑制剂)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=44a360, createdName=jklm09, createdTime=Mon Nov 02 09:39:28 CST 2020, time=2020-11-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1524877, encodeId=05a115248e73b, content=<a href='/topic/show?id=4ba395994d' target=_blank style='color:#2F92EE;'>#II期临床#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9599, encryptionId=4ba395994d, topicName=II期临床)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=139811614978, createdName=guihongzh, createdTime=Mon Oct 12 12:39:28 CST 2020, time=2020-10-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=891187, encodeId=7d8d89118e51, content=棒棒哒,加油, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=75c55424163, createdName=ms9000001186008086, createdTime=Sun Oct 11 01:05:29 CST 2020, time=2020-10-11, status=1, ipAttribution=)]
  6. [GetPortalCommentsPageByObjectIdResponse(id=1754942, encodeId=cabb1e549422e, content=<a href='/topic/show?id=bf6093140d4' target=_blank style='color:#2F92EE;'>#路易体#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=93140, encryptionId=bf6093140d4, topicName=路易体)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=576436807451, createdName=longerg, createdTime=Tue Jul 27 10:39:28 CST 2021, time=2021-07-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1836234, encodeId=0fa41836234ed, content=<a href='/topic/show?id=4613e1212fc' target=_blank style='color:#2F92EE;'>#痴呆症#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71212, encryptionId=4613e1212fc, topicName=痴呆症)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=726030, createdName=Boyinsh, createdTime=Sat Jun 05 20:39:28 CST 2021, time=2021-06-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2086564, encodeId=04952086564e2, content=<a href='/topic/show?id=424613621d3' target=_blank style='color:#2F92EE;'>#p38α#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13621, encryptionId=424613621d3, topicName=p38α)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6c32257, createdName=DEXTER3139, createdTime=Thu Jul 22 02:39:28 CST 2021, time=2021-07-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2011755, encodeId=d6722011e5593, content=<a href='/topic/show?id=f0ed106e342' target=_blank style='color:#2F92EE;'>#LAMA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10673, encryptionId=f0ed106e342, topicName=LAMA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=85aa264, createdName=redcrab, createdTime=Thu Apr 29 07:39:28 CST 2021, time=2021-04-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1764203, encodeId=bf9f1e642038d, content=<a href='/topic/show?id=90079314208' target=_blank style='color:#2F92EE;'>#路易体痴呆症#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=93142, encryptionId=90079314208, topicName=路易体痴呆症)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=78a737641523, createdName=12498b3em20(暂无昵称), createdTime=Sun Aug 22 06:39:28 CST 2021, time=2021-08-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1653103, encodeId=52ad165310389, content=<a href='/topic/show?id=5b011018e07' target=_blank style='color:#2F92EE;'>#I期临床#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10187, encryptionId=5b011018e07, topicName=I期临床)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=fc1f24335670, createdName=医生2402, createdTime=Sun Mar 07 13:39:28 CST 2021, time=2021-03-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2057692, encodeId=7389205e69257, content=<a href='/topic/show?id=c02b106e29a' target=_blank style='color:#2F92EE;'>#LAM#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10672, encryptionId=c02b106e29a, topicName=LAM)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=04ce158, createdName=lxg951, createdTime=Mon May 03 13:39:28 CST 2021, time=2021-05-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1852505, encodeId=6bb81852505c1, content=<a href='/topic/show?id=f0a254918f0' target=_blank style='color:#2F92EE;'>#抑制剂#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54918, encryptionId=f0a254918f0, topicName=抑制剂)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=44a360, createdName=jklm09, createdTime=Mon Nov 02 09:39:28 CST 2020, time=2020-11-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1524877, encodeId=05a115248e73b, content=<a href='/topic/show?id=4ba395994d' target=_blank style='color:#2F92EE;'>#II期临床#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9599, encryptionId=4ba395994d, topicName=II期临床)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=139811614978, createdName=guihongzh, createdTime=Mon Oct 12 12:39:28 CST 2020, time=2020-10-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=891187, encodeId=7d8d89118e51, content=棒棒哒,加油, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=75c55424163, createdName=ms9000001186008086, createdTime=Sun Oct 11 01:05:29 CST 2020, time=2020-10-11, status=1, ipAttribution=)]
  7. [GetPortalCommentsPageByObjectIdResponse(id=1754942, encodeId=cabb1e549422e, content=<a href='/topic/show?id=bf6093140d4' target=_blank style='color:#2F92EE;'>#路易体#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=93140, encryptionId=bf6093140d4, topicName=路易体)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=576436807451, createdName=longerg, createdTime=Tue Jul 27 10:39:28 CST 2021, time=2021-07-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1836234, encodeId=0fa41836234ed, content=<a href='/topic/show?id=4613e1212fc' target=_blank style='color:#2F92EE;'>#痴呆症#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71212, encryptionId=4613e1212fc, topicName=痴呆症)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=726030, 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encryptionId=f0ed106e342, topicName=LAMA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=85aa264, createdName=redcrab, createdTime=Thu Apr 29 07:39:28 CST 2021, time=2021-04-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1764203, encodeId=bf9f1e642038d, content=<a href='/topic/show?id=90079314208' target=_blank style='color:#2F92EE;'>#路易体痴呆症#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=93142, encryptionId=90079314208, topicName=路易体痴呆症)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=78a737641523, createdName=12498b3em20(暂无昵称), createdTime=Sun Aug 22 06:39:28 CST 2021, time=2021-08-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1653103, encodeId=52ad165310389, content=<a href='/topic/show?id=5b011018e07' target=_blank style='color:#2F92EE;'>#I期临床#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10187, encryptionId=5b011018e07, topicName=I期临床)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=fc1f24335670, createdName=医生2402, createdTime=Sun Mar 07 13:39:28 CST 2021, time=2021-03-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2057692, encodeId=7389205e69257, content=<a href='/topic/show?id=c02b106e29a' target=_blank style='color:#2F92EE;'>#LAM#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10672, encryptionId=c02b106e29a, topicName=LAM)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=04ce158, createdName=lxg951, createdTime=Mon May 03 13:39:28 CST 2021, time=2021-05-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1852505, encodeId=6bb81852505c1, content=<a href='/topic/show?id=f0a254918f0' target=_blank style='color:#2F92EE;'>#抑制剂#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54918, encryptionId=f0a254918f0, topicName=抑制剂)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=44a360, createdName=jklm09, createdTime=Mon Nov 02 09:39:28 CST 2020, time=2020-11-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1524877, encodeId=05a115248e73b, content=<a href='/topic/show?id=4ba395994d' target=_blank style='color:#2F92EE;'>#II期临床#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9599, encryptionId=4ba395994d, topicName=II期临床)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=139811614978, createdName=guihongzh, createdTime=Mon Oct 12 12:39:28 CST 2020, time=2020-10-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=891187, encodeId=7d8d89118e51, content=棒棒哒,加油, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=75c55424163, createdName=ms9000001186008086, createdTime=Sun Oct 11 01:05:29 CST 2020, time=2020-10-11, status=1, ipAttribution=)]
    2021-05-03 lxg951
  8. 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time=2020-10-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=891187, encodeId=7d8d89118e51, content=棒棒哒,加油, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=75c55424163, createdName=ms9000001186008086, createdTime=Sun Oct 11 01:05:29 CST 2020, time=2020-10-11, status=1, ipAttribution=)]
    2020-11-02 jklm09
  9. 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time=2020-10-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=891187, encodeId=7d8d89118e51, content=棒棒哒,加油, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=75c55424163, createdName=ms9000001186008086, createdTime=Sun Oct 11 01:05:29 CST 2020, time=2020-10-11, status=1, ipAttribution=)]
  10. 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    2020-10-11 ms9000001186008086

    棒棒哒,加油

    0

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