Science:每年感染7亿人,这种病毒“赖在”肠道中的秘诀被发现了

2018-04-17 Tierna 生物探索

诺如病毒(Norwalk Viruses,NV)向来臭名昭著,它能引起突发呕吐和腹泻,可导致每年7亿人感染和20万人死亡。那么,究竟这种细菌是如何在体内生根的呢? 最新一项研究为我们揭晓了这一答案。

诺如病毒(Norwalk Viruses,NV)向来臭名昭著,它能引起突发呕吐和腹泻,可导致每年7亿人感染和20万人死亡。那么,究竟这种细菌是如何在体内生根的呢? 最新一项研究为我们揭晓了这一答案。
 

This 3D graphical representation of norovirus particles is based on electron microscopic imagery of actual virus particles.Credit: CDC/Jessica A. Allen

相关研究结果于4月12日以 “Tropism for tuft cells determines immune promotion of norovirus pathogenesis”为题在《科学》杂志上发表。圣路易斯华盛顿大学医学院病理学和免疫学讲师Craig Wilen博士为该研究主要作者。

1.诺如病毒致病机理

通过对小鼠的诺如病毒感染进行探索,研究人员发现,被诺如病毒感染的肠道细胞称为tuft细胞,这种细胞表面有毛发状突起。有趣的是,这些细胞相对稀少,只占人体肠道细胞总数的一小部分。

“我们最惊讶的是,这种病毒竟能感染如此罕见的细胞类型,此外即使感染的tuft细胞很少,这种感染也会很强烈,而且很容易传播,直至引发严重感染,”Craig Wilen博士在一次报告中指出,“例如,在单个小鼠身上,可能只有100个细胞被感染,与流感等其他病毒相比,这是非常少的。”

目前,该研究仅在小鼠试验阶段,未来研究人员仍需要在人身上证实这一发现。但他们说,如果该研究结果对人也是正确的,那么,用药物或疫苗靶向tuft细胞可能有助于治疗或预防相关疾病。

2.致命感染

根据疾病控制和预防中心(Centers for Disease Control and Prevention,简称CDC)的数据,大多数感染诺如病毒的人在一到三天内就会好转。但在某些情况下,这种病毒可能是致命的。据估计,全球每年有20万人死于诺如病毒,且主要是在发展中国家。

根据这项研究解释,发展中国家寄生虫感染更为常见,而tuft细胞被认为有助于检测体内的寄生虫感染,并引发对寄生虫的免疫反应。但自相矛盾的是,这种免疫反应可能是诺如病毒的福音。研究人员说,免疫反应导致tuft细胞数量增加5到10倍,从而使诺如病毒能够更有效地复制。

诺如病毒健康携带者,他们看起来并不生病,但仍然具有传染性,通常被认为是诺如病毒爆发的根源。

“而我们的发现可能也有助于解释为什么上述这些人在症状恢复后很长时间仍继续‘脱落’诺如病毒。”研究人员说。当诺如病毒进入tuft细胞时,它有效地“隐藏”在免疫系统中,这将使其难以从体内消除。

3.意义

这项新的研究提出了一个问题,即,那些患有慢性诺如病毒感染并在感染后很久仍继续‘脱落’病毒的人是否是因为病毒仍然隐藏在tuft细胞中。Wilen博士说:“如果是这样,靶向tuft细胞可能是根除病毒的重要策略。”

原始出处:Wilen CB, Lee S, Hsieh LL, et al. Tropism for tuft cells determines immune promotion of norovirus pathogenesis. Science. 2018 Apr 13;360(6385):204-208.

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    2018-08-15 wuqianhong99

    很好!谢谢分享,学习了

    0

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    2018-04-19 zanzaifeng

    重大发现又是

    0

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    2018-04-18 jichang
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    2018-04-17 flysky120

    发现的越早越好

    0

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    2018-04-17 龙胆草

    学习谢谢分享

    0

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    2018-04-17 wzb521zf

    一起学习学习

    0

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    2018-04-17 张新亮1853311252142e2fm

    好文献.学习了

    0

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    2018-04-17 chunjianf

    学习了.谢谢分享

    0

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    2018-04-17 医者仁心5538

    学习了

    0

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我校近期突发诺如病毒感染事件,为严防疫情继续扩散,确保师生身体健康和校园安全……现暂时实行校园封闭管理措施。”3月22日,一则落款为“广东培正学院”的《关于学校暂时实行封闭管理措施的通知》在网上热传。该通知规定“封校”时间为3月22日11时起至疫情解除为止,“原则上全体学生不得出校,特殊情况需向辅导员申请出校通行证。学校教职工需出示工作证”。《通知》还附有一张学校地图,标明禁止通行的区域。&n

广东发布诺如病毒感染预警 12月份报告14起疫情

据传染病疫情监测显示,12月份以来,广东报告诺如病毒感染暴发疫情起数明显上升,12月以来已报告疫情14起,该省卫计委28日发布诺如病毒感染预警信息,提醒各地机关和民众加强防范。截至12月26日,2016年广东共报告34起诺如病毒感染暴发疫情(2015年共报告44起),其中1月2起、2月3起、3月5起、4月和6月各1起、9月3起、11月5起、12月14起。在今年报告的34起疫情中,有29起发生在学校

南京一职校十多学生陆续出现腹泻呕吐,官方:诺如病毒感染

从4月11日凌晨起,江苏省重点职业学校、南京财经学校江宁校区十多名学生陆续出现的“集体腹泻呕吐”事件,现已初步查清,排除了食物中毒的可能。记者从南京市江宁区湖熟中心卫生院了解到,从4月11日凌晨开始,陆续学生来卫生院看病,主要症状是腹部不适,主要表现为呕吐、腹泻。4月12日,江宁区卫生局工作人员对澎湃新闻表示,已经排除食物病毒可能,通过疾控中心的检测,初步判断为诺如病毒感染,目前疫情已经得到控制。

口服诺如病毒疫苗的新近进展

Vaxart是一家正处于临床阶段的生物技术公司,其主要业务集中于开发口服重组疫苗,这种疫苗的剂型为片剂而非注射剂,患者的依从性会更好。目前Vaxart宣布将提供其诺如病毒口服片剂疫苗的两项I期临床研究的试验数据,这些数据将于2018年3月1日至4日在阿根廷布宜诺斯艾利斯举行的第18届国际传染病大会(ICID)上公布

J Hosp Infect:诺如病毒感染暴发时不能探视患者,你接受吗?

背景诺如病毒是引起全球范围内暴发和最常导致病房关闭停止医疗服务的主要原因。诺如病毒暴发期间,为减少暴露、传播和危害,暂时停止探视(TSV)是越来越被推荐的一项公共健康措施。然而,防止患者和探视者接触可能违背了以患者为中心的照护理念,而且目前尚不知晓公众对此项措施的可接受性。目的在诺如病毒暴发期间,从患者、探视者和公众的角度调查TSV的可接受性。方法在苏格兰3个不同的区域开展针对患者(N=153)、