DCR: PEG10基因的差异表达有助于早期发病与晚期发作性大肠癌的疾病侵略性

2020-11-09 MedSci原创 MedSci原创

大肠癌是全球癌症相关死亡的主要原因。早发性大肠癌(年龄≤45岁)正在逐年增加,并与晚期进展有关。尽管已鉴定出大肠癌的不同分子亚型,但尚不清楚是否存在与年龄相关的分子差异。

背景及目的:

大肠癌是全球癌症相关死亡的主要原因。早发性大肠癌(年龄≤45岁)正在逐年增加,并与晚期进展有关。尽管已鉴定出大肠癌的不同分子亚型,但尚不清楚是否存在与年龄相关的分子差异。本项研究旨在探究早期和晚期(年龄≥65岁)大肠癌之间基因表达的差异。

 

 

方法:

研究人员对所有在一个三级转诊医疗中心的大肠癌患者进行了回顾性审查,并收集了可用于分析组织标本的大肠癌患者。使用《癌症基因组图谱》初步鉴定了早发性和晚发性大肠癌之间基因表达的差异,并在2种结直肠癌细胞系上进行了体外实验。主要观察结果是早期和晚期发病的大肠癌患者的差异基因表达,次要结果是患者死亡率。

 

 

结果:

本项研究共纳入28名早发大肠癌患者以及38名晚发大肠癌患者。基因测序发现七个基因在年轻患者中的表达增加。在定量聚合酶链反应中只有PEG10过表达,并且在早期发病组中表达增加。多变量线性回归分析确定年龄是PEG10表达增加的重要独立预测因子。癌症基因组图谱的结果数据表明PEG10与较差的总体存活率有关。在HCT-116和HT-29细胞系中进行的体外研究表明,PEG10有助于大肠癌的细胞增殖和侵袭。

 

 

结论:

PEG10在早期发病的大肠癌中差异表达,可能在功能上促进肿瘤细胞的增殖和侵袭。PEG10表达的增加与总生存期降低有关。

 

原始出处:

Watson, Katherine M. et al. Differential Expression of PEG10 Contributes to Aggressive Disease in Early Versus Late-Onset Colorectal Cancer. Diseases of the Colon & Rectum.2020.

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    2020-11-11 14861974m47(暂无昵称)

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