JCEM:卵巢储备生物标志物与月经周期长度

2021-04-29 MedSci原创 MedSci原创

AMH水平升高与月经周期延长有关,这是由于卵泡期和黄体期的延长与年龄无关。

尽管与年龄相关的月经周期长度变化众所周知,但尚不清楚AMH或其他卵巢储备生物标记物是否与周期长度直接相关。

近日,内分泌和代谢性疾病领域权威杂志Journal of Clinical Endocrinology & Metabolism上发表了一篇研究文章,该研究旨在明确卵巢储备生物标志物与月经周期长度之间的关系。

研究人员使用妊娠时机的前瞻性研究(TTC)数据进行了二次分析,并使用线性混合和边际模型分析了周期长度与卵巢储备生物标志物之间与年龄无关的相关性。

该研究招募了30至44岁、未怀孕且尝试怀孕时间少于3个月的女性。在第2、3或4天测量了血清AMH、FSH和抑制素B水平。参与者记录月经周期的每日数据。该研究的主要结局指标为月经周期长短。卵泡期和黄体期的长短是其次要结局。

多变量分析纳入了来自632名女性的1880次月经周期。与AMH<1.6 ng/mL相比,AMH<1.6 ng/mL的女性月经周期和卵泡期分别缩短了0.98(95%置信区间(CI):-1.46,-0.50)和1.58天(95%CI:-2.53,-0.63),而AMH>8 ng/mL的妇女月经周期延长了2.15天(95%CI:1.46,2.83),卵泡期延长了2天(95%CI为0.77, 3.24)和黄体期延长了1.80天(95%CI为0.71,2.88)。

由此可见,AMH水平升高与月经周期延长有关,这是由于卵泡期和黄体期的延长与年龄无关。

原始出处:

Benjamin S Harris.et al.Ovarian Reserve Biomarkers and Menstrual Cycle Length in a Prospective Cohort Study.JCEM.2021.https://pubmed.ncbi.nlm.nih.gov/33772306/

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    2021-06-02 smallant2015
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    2022-03-06 achengzhao
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    2021-05-01 luwei00
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