JAMA Cardiol :78%新冠康复者存在心肌损伤,轻症患者同样面临风险

2020-07-31 药明康德内容团队 医学新视点

新冠病毒不止引起呼吸道问题,还可以攻击、影响人体的多处器官,心脏也是其中之一。那么,急性感染期过后,是否还有长期影响?《美国医学会杂志-心脏病学》近日发表的一项研究提示,患者在康复后普遍患有心肌损伤。

我们知道,新冠病毒不止引起呼吸道问题,还可以攻击、影响人体的多处器官,心脏也是其中之一。那么,急性感染期过后,是否还有长期影响?《美国医学会杂志-心脏病学》近日发表的一项研究提示,患者在康复相当长一段时间后,还普遍患有心肌损伤。

研究来自德国法兰克福大学医院(University Hospital Frankfurt)团队,分析了100名近期从新冠病毒疾病(COVID-19)中康复的患者是否存在心肌损伤情况,其中67名病情较轻在家康复,33名曾住院治疗。所有患者此前都没有心力衰竭或心肌疾病病史。对所有患者进行心脏血液标志物和血管磁共振影像学检查,检查与确诊COVID-19的平均间隔为71天。

结果发现,71名康复者体内都可检测到高敏肌钙蛋白T(hsTnT,心肌损伤标志物),有5位患者的肌钙蛋白T明显升高。

在影像学检查中,78%的康复者出现了心肌损伤的迹象。尤其值得关注的是,分别有73名和60名患者出现心肌天然T1和T2升高,天然T1和T2是识别COVID-19相关心肌病理状态的有效指标,这意味着60%的患者存在持续性的心肌炎。

与另外50名健康受试者和57名风险因素匹配受试者对比也显示,COVID-19康复者的左心室射血分数较低,左心室容积和质量增加,并且心肌天然T1和T2升高。

研究团队指出,“COVID-19患者康复后的几周内,心肌中仍然有大量持续性炎症,包括既往心血管疾病较少而且主要在家康复的患者,严重程度和住院患者相似。这一发现很重要,因为可能预示着几年后患者将面临心脏衰竭的风险,而早期诊断和治疗可以减轻甚至停止这种炎症损伤。”

贝勒医学院(Baylor College of Medicine)Biykem Bozkurt博士点评建议,对于COVID-19患者应筛查心肌损伤情况,比如检查肌钙蛋白,“可能不仅在入院时,出院时也需要检查,甚至是对于那些在家康复没有住院的人来说也是如此。

原始出处:
Valentina O Puntmann 1, M Ludovica Carerj 1 2, Imke Wieters 3,et al.Outcomes of Cardiovascular Magnetic Resonance Imaging in Patients Recently Recovered From Coronavirus Disease 2019 (COVID-19).JAMA Cardiol. 2020 Jul 27. doi: 10.1001/jamacardio.2020.3557.

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    2020-07-31 公卫新人

    新冠肺炎,疫情何时才能消失

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1016783, encodeId=51641016e8318, content=<a href='/topic/show?id=f4a581085cc' target=_blank style='color:#2F92EE;'>#肌钙蛋白#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=91, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81085, encryptionId=f4a581085cc, topicName=肌钙蛋白)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211210/ede9c51184aa4f54ae6c1164cfb8eeac/967dbf3eff2943c7bf3ccfec3a776ab0.JPG, createdBy=a33789389, createdName=病毒猎手, createdTime=Sun Sep 12 15:25:49 CST 2021, time=2021-09-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1782090, encodeId=c9df1e8209081, content=<a href='/topic/show?id=5db8409ed8' target=_blank style='color:#2F92EE;'>#Cardiol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4097, encryptionId=5db8409ed8, topicName=Cardiol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d7532500500, createdName=12499e01m47暂无昵称, createdTime=Thu Oct 22 02:06:12 CST 2020, time=2020-10-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1310083, encodeId=58391310083ba, content=<a href='/topic/show?id=ddd95126e4e' target=_blank style='color:#2F92EE;'>#心肌损伤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=51267, encryptionId=ddd95126e4e, topicName=心肌损伤)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4723380, createdName=yangcx0915, createdTime=Sun Aug 02 02:06:12 CST 2020, time=2020-08-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1398021, encodeId=124f13980216d, content=<a href='/topic/show?id=8bee565436d' target=_blank style='color:#2F92EE;'>#损伤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=56543, encryptionId=8bee565436d, topicName=损伤)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83eoNX3lUOlDKGBUEPNwZx0nibmdcFyeibnX4WMhUSCU2REpGRWtSmnT2CCs0dA5waxvJknYDxwtYnIcQ/132, createdBy=294e2500218, createdName=ms3046638856685384, createdTime=Sun Aug 02 02:06:12 CST 2020, time=2020-08-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1028362, encodeId=962210283629c, content=新冠肺炎,疫情何时才能消失, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=公卫新人, createdTime=Fri Jul 31 14:06:12 CST 2020, time=2020-07-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1036199, encodeId=7bc51036199b8, content=顶刊就是顶刊,谢谢梅斯带来这么高水平的研究报道,我们科里同事经常看梅斯,分享梅斯上的信息, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=旺医, createdTime=Fri Jul 31 14:06:12 CST 2020, time=2020-07-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=805368, encodeId=6385805368a7, content=<a href='/topic/show?id=46ce580e865' target=_blank style='color:#2F92EE;'>#新冠肺炎#</a>可能是因为损伤的血管内皮细胞,继发心肌损伤,这种损伤可能是长期的,更远期而言,有可能会引发纤维化。, beContent=null, objectType=article, channel=null, level=null, likeNumber=90, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=58078, encryptionId=46ce580e865, topicName=新冠肺炎)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Fri Jul 31 13:46:13 CST 2020, time=2020-07-31, status=1, ipAttribution=)]
    2020-07-31 旺医

    顶刊就是顶刊,谢谢梅斯带来这么高水平的研究报道,我们科里同事经常看梅斯,分享梅斯上的信息

    0

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    2020-07-31 lovetcm

    #新冠肺炎#可能是因为损伤的血管内皮细胞,继发心肌损伤,这种损伤可能是长期的,更远期而言,有可能会引发纤维化。

    0

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