Pediatrics:母乳喂养可降低早产儿视网膜病变风险

2015-11-22 Mechront 译 MedSci原创

有研究表明母乳喂养可降低早产儿视网膜病变 (ROP)发生率,不过也有研究提出了矛盾的结果。研究者进行了一样荟萃分析,探究母乳和配方奶喂养对ROP发生率的影响。研究者检索了Medline, PubMed, and EBSCO等数据库,关于比较母乳和配方奶喂养对ROP发生率影响的纵向研究。该荟萃分析未纳入捐赠的母乳喂养。该荟萃分析共纳入了5篇研究,涉及2208名早产儿。总体上对任何阶段的ROP,唯一的

有研究表明母乳喂养可降低早产儿视网膜病变 (ROP)发生率,不过也有研究提出了矛盾的结果。研究者进行了一样荟萃分析,探究母乳和配方奶喂养对ROP发生率的影响。

研究者检索了Medline, PubMed, and EBSCO等数据库,关于比较母乳和配方奶喂养对ROP发生率影响的纵向研究。该荟萃分析未纳入捐赠的母乳喂养。

该荟萃分析共纳入了5篇研究,涉及2208名早产儿。总体上对任何阶段的ROP,唯一的母乳喂养vs任何配方奶 OR= 0.29 (0.12 to 0.72);母乳为主vs配方奶为主 OR=0.51 (0.26 to 1.03);任何母乳vs唯一的配方奶 OR=0.54 (0.15 to 1.96);唯一的母乳vs唯一的配方奶OR=0.25 (0.13 to 0.49)。对于严重ROP,上述比较各组OR值分别为0.11 (0.04 to 0.30), 0.16 (0.06 to 0.43), 0.42 (0.08 to 2.18), 以及0.10 (0.04 to 0.29)。

因为伦理问题,进行前瞻性随机研究是不可能的,研究者选择观察性研究进行荟萃分析,同时亚组分析异质性高等均是该荟萃分析的不足之处。

目前有限的证据表明,对极早产儿母乳喂养可降低任何阶段或严重ROP的发生。

原始出处:

Zhou J, Shukla VV,et al.Human Milk Feeding as a Protective Factor for Retinopathy of Prematurity: A Meta-analysis.Pediatrics. 2015 Nov 16.

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    2016-07-14 hbwxf
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    2016-01-01 feather89
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    2015-11-24 villahu
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