Circulation:高左心室肥厚风险个体的心肌僵硬度增加

2020-01-28 QQY MedSci原创

中年时左心室肥厚(LVH)和心肌生物标志物升高的个体,在保留射血分数(HFpEF)的情况下,具有较高的发展为心力衰竭的风险。但目的尚不清楚这种高风险状态的病理生理基础是什么。研究人员推测,与健康对照组相比,LVH和心肌生物标志物升高的患者的左心室(LV)心肌硬度升高(可能是未来HFpEF的一个关键指标),研究人员对此展开验证。招募了46位心肌生物标志物升高(NT-proBNP>40 pg/m

中年时左心室肥厚(LVH)和心肌生物标志物升高的个体,在保留射血分数(HFpEF)的情况下,具有较高的发展为心力衰竭的风险。但目的尚不清楚这种高风险状态的病理生理基础是什么。研究人员推测,与健康对照组相比,LVH和心肌生物标志物升高的患者的左心室(LV)心肌硬度升高(可能是未来HFpEF的一个关键指标),研究人员对此展开验证。

招募了46位心肌生物标志物升高(NT-proBNP>40 pg/mL或肌钙蛋白T>0.6 pg/mL)的LVH(左室壁>11 mm)患者和61位年龄、性别相匹配的健康对照。研究人员采用右心导管和三维超声心动图,同时使用下体负压和生理盐水快速灌注,来明确左室压力-容积关系。

两组个体的体型、血压、肺毛细血管楔压等指标具有显著差异(如肺毛细血管楔压,LVH组 vs 对照组:13.4±2.7 vs 11.7±1.7 mm Hg, P<0.0001)。与对照组相比,LVH组的LV扩张程度较轻。生理盐水快速灌注时,LVH组的LV心肌僵硬度比对照组高出近30%。

心肌生物标志物升高的LVH患者的LV心肌僵硬度高于年龄和性别匹配的对照组个体,这似乎代表了从正常健康心脏到HFpEF的过渡状态。虽然在早期,LVH患者的左室心肌僵硬度大于健康对照组,但还需要深入研究来明确,在这类高危人群中,运动训练等可改善左室顺应性的干预措施是否可预防HFpEF综合征。

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