J Gastroenterology:内脏脂肪与巴雷特食管之间的关联

2020-02-06 不详 MedSci原创

腹部内脏肥胖与白种人的Barrett食道(BE)有关,尤其是长段BE(≥3 cm)(LSBE)。然而,在亚洲,中枢性肥胖与LSBE之间的关联尚未得到很好的研究。这项研究的目的是调查日本人群中中心肥胖与LSBE之间的关系。

背景
腹部内脏肥胖与白种人的Barrett食道(BE)有关,尤其是长段BE(≥3 cm)(LSBE)。然而,在亚洲,中枢性肥胖与LSBE之间的关联尚未得到很好的研究。这项研究的目的是调查日本人群中中心肥胖与LSBE之间的关系。

方法
在2006年4月至2018年11月期间,共有38298名健康受试者参加了医学检查。研究人员使用多变量logistic回归模型研究了LSBE与肥胖中心指数[内脏脂肪组织(VAT),皮下脂肪组织(SAT)和VAT与SAT的比率(VAT / SAT)]之间的关联。

结果
共有37686名受试者符合分析条件。中低VAT / SAT组的LSBE率高于低VAT / SAT组[优势比(OR)1.70,95%置信区间(CI)1.07–2.69;OR 2.02,95%CI 1.17–3.49(高低)]。VAT / SAT和LSBE之间的这些关联趋势仍然存在于有和没有反流性食管炎的亚组中。从SAT的子组分析中,我们发现,低SAT中VAT和LSBE之间的OR较高(OR = 2.43,中低vs. 95%CI 1.34–4.40; OR 2.55,95%CI 1.01–6.40)。

结论
VAT与LSBE有关,尤其是在SAT较少的患者中,这样的关联更明显。

原始出处:

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    2020-10-13 许安
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    2020-02-08 zhouqu_8
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