J AM HEART ASSOC:什么?骨中的铅含量还与顽固性高血压有关?

2018-10-30 xujing 中国循环杂志

密歇根大学公共卫生学院流行病学和环境健康科学系学者在《美国心脏协会杂志》发表的一项研究提示,胫骨中铅含量的积累与顽固性高血压有关。

密歇根大学公共卫生学院流行病学和环境健康科学系学者在《美国心脏协会杂志》发表的一项研究提示,胫骨中铅含量的积累与顽固性高血压有关。

研究者指出,一旦铅进入人体,就很难将其祛除,大部分铅在人的骨里累积下来,人变老,骨头变弱时,铅会被释放到血液中并影响血压控制。

这项前瞻性队列研究纳入21~80岁的475名男性受试者。

顽固性高血压定义为使用三种药物时收缩压仍大于140/90 mmHg或需要四种以上药物来控制血压

本队列中,20.4%(97/475)的受试者有顽固性高血压,他们的胫骨和髌骨的铅含量分别为20 μg/g和25 μg/g。

而无顽固性高血压受试者的胫骨和髌骨铅含量分别为20 μg/g和27.5 μg/g。

研究人员发现,顽固性高血压与胫骨铅含量每四分位范围(13~28.5μg/g)增加有关(RR=1.19;95%CI:1.01-1.41, P=0.04)。

顽固性高血压与髌骨铅每四分位范围(18~40 μg/g)增加无关(RR=1.1;95%CI,0.92-1.31, P=0.31)。

而且,高血压与血铅水平无相关性(RR=1.11;95% CI,0.88~1.4, P=0.38)。

原始出处:
Alexander R. Zheutlin et al. Low‐Level Cumulative Lead and Resistant Hypertension: A Prospective Study of Men Participating in the Veterans Affairs Normative Aging Study. Originally published 24 Oct 2018. Journal of the American Heart Association.2018, 7:e010014.

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    2018-11-01 zhaojie88
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    2018-11-01 slcumt

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