Intern Med J:幽门螺杆菌感染或增加胃肠道癌症化疗诱导的呕吐

2017-07-24 吴刚 环球医学

据统计,全球约有44亿幽门螺杆菌感染者,在中国这一数字更是达到了令人吃惊的7.68亿,达到50%!恶心和呕吐为化疗最常见的不良反应。2017年7月,发表在《Intern Med J》的一项研究表明,幽门螺杆菌感染或增加胃肠道癌症化疗诱导的呕吐。



据统计,全球约有44亿幽门螺杆菌感染者,在中国这一数字更是达到了令人吃惊的7.68亿,达到50%!恶心和呕吐为化疗最常见的不良反应。2017年7月,发表在《Intern Med J》的一项研究表明,幽门螺杆菌感染或增加胃肠道癌症化疗诱导的呕吐。

目的:旨在讨论幽门螺杆菌感染和化疗诱导的恶心和呕吐(CINV)之间的相关性。

方法:总共选取了112名胃肠道恶性肿瘤患者。基于14C尿素呼气试验结果,患者分为幽门螺杆菌阳性(59人)和阴性(53人)组。两组在化疗期间都接受了预防性止吐治疗。恶心和呕吐的发生率及其对患者生活功能的影响使用化疗后0~120小时的多国癌症支持治疗协会(MASCC)的止吐工具(MAT)和生活功能指数呕吐(FLIE)进行评估,同时对阳性组和阴性组的评估结果进行了比较。

结果:幽门螺杆菌阴性组比阳性组的恶心和呕吐缓解率高。阴性组中,恶心和呕吐对日常生活无影响(NIDL)的患者比例分别为73.4%和75.5%。阴性组比阳性组NIDL患者比例高(P<0.001,P=0.046)。研究人员进行了多变量非条件逻辑回归分析,结果表明,幽门螺杆菌感染是影响FLIE恶心评分的因素(比值比,0.757;95% CI,0.597~0.960;P=0.021)。

结论:癌症患者幽门螺杆菌感染是增加CINV的一个因素。

原始出处:

Yao Y, Ji C, He Y,et al. Relationship between Helicobacter pylori infection and vomiting induced by gastrointestinal cancer chemotherapy. Intern Med J. 2017 Jul;47(7):792-797. doi: 10.1111/imj.13428.

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    2018-04-06 kcb069
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    2017-07-24 hhh678

    henhao

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=1811724, encodeId=74dc1811e2489, content=<a href='/topic/show?id=751f8889423' target=_blank style='color:#2F92EE;'>#螺杆菌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=88894, encryptionId=751f8889423, topicName=螺杆菌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=87b1109, createdName=kcb069, createdTime=Fri Apr 06 10:22:00 CST 2018, time=2018-04-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2058692, encodeId=fb2d2058692f4, content=<a href='/topic/show?id=acdce132383' target=_blank style='color:#2F92EE;'>#癌症化疗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71323, encryptionId=acdce132383, topicName=癌症化疗)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7d74253, createdName=wangtianj2007@, createdTime=Wed Sep 20 11:22:00 CST 2017, time=2017-09-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2042226, encodeId=3f9e204222697, content=<a href='/topic/show?id=213b8334e10' target=_blank style='color:#2F92EE;'>#胃肠道癌症#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83347, encryptionId=213b8334e10, topicName=胃肠道癌症)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3289320, createdName=海豹, createdTime=Wed Nov 01 13:22:00 CST 2017, time=2017-11-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1346229, encodeId=3c46134622974, content=<a href='/topic/show?id=339e8332035' target=_blank style='color:#2F92EE;'>#胃肠道#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83320, encryptionId=339e8332035, topicName=胃肠道)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=395f25, createdName=爆笑小医, createdTime=Wed Jul 26 03:22:00 CST 2017, time=2017-07-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1348709, encodeId=fb611348e0912, content=<a href='/topic/show?id=cfeb49103af' target=_blank style='color:#2F92EE;'>#幽门螺杆菌感染#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=49103, encryptionId=cfeb49103af, topicName=幽门螺杆菌感染)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6ab940, createdName=hukaixun, createdTime=Wed Jul 26 03:22:00 CST 2017, time=2017-07-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1607866, encodeId=560d160e866a9, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Wed Jul 26 03:22:00 CST 2017, time=2017-07-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=225859, encodeId=0a1022585939, content=henhao, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NcXNhUvfhzd2VdicMnaLeK2Im5gKx4Ucxd8Bwu6S7RG0uILBFQx5HTW2bU4VricDYlQqN20ibASSMYAeGrZrrTpy2Q/0, createdBy=b0041939716, createdName=hhh678, createdTime=Mon Jul 24 16:03:05 CST 2017, time=2017-07-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=225800, encodeId=0fc1225800a2, content=学习了,谢谢。, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/xkvRjYnJzzRJ2R0y7VhicibvkjPWHjIMmu4ZpKnE9cWAu4lVicS3uDUCfF4M4JWvrkrYfpb2KehPV0Ee29tPqyPEebBUibiaKhnvD/0, createdBy=f8412001184, createdName=惠映实验室, createdTime=Mon Jul 24 12:50:50 CST 2017, time=2017-07-24, status=1, ipAttribution=)]
    2017-07-24 惠映实验室

    学习了,谢谢。

    0

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