Gastroenterology:法莫替丁的使用与住院COVID-19患者的临床结果改善相关

2020-09-24 MedSci原创 MedSci原创

2019年年末开始的冠状病毒病(COVID-19)在全球造成3000万病例感染,超过90万例死亡。到目前为止,尚未有任何药物被证明可改善预后。

        2019年年末开始的冠状病毒病(COVID-19)在全球造成3000万病例感染,超过90万例死亡。到目前为止,尚未有任何药物被证明可改善COVID-19患者的预后。法莫替丁是抑制胃酸产生的组胺2受体拮抗剂。在体外,法莫替丁可以抑制人免疫缺陷病毒的复制。最近有研究通过算法预测了严重急性呼吸系统综合症冠状病毒2(SARS-CoV-2)基因组编码的蛋白质的结构,并确定法莫替丁是最有可能抑制3-胰凝乳蛋白酶样蛋白酶的药物之一。因此,研究人员假设法莫替丁在住院的COVID-19患者中可改善临床疗效,为了探索这一点,研究人员进行了一项单中心的队列研究。

 

        研究人员收集了从2020年2月25日到2020年4月13日间被确诊为SARS-CoV-2阳性的患者,主要干预措施是使用法莫替丁进行治疗(任何剂量,任何形式的给药方式或持续时间都可),主要观察结局是从医院第2天到第30天死亡或气管插管的复合结果(无插管生存率)。

 

 

        结果显示:共有1620例患者符合纳排标准,其中84例(5.1%)在入院24小时内接受了法莫替丁治疗。所有法莫替丁剂量中有28%为静脉注射。47%为20毫克,35%为40毫克,17%为10毫克。法莫替丁使用者平均服药5.8天,中位总剂量为136 mg(63-233 mg)。共有142名(8.8%)的患者被插管,其中238名(15%)死亡;在粗略分析中,法莫替丁的使用与死亡或插管综合结果的风险降低显着相关(P<0.01)。在调整了基线患者特征后,法莫替丁的使用仍然是死亡或插管的风险独立危险因素。

 

        这项回顾性研究发现,在住院COVID-19的患者中,法莫替丁的使用与导致插管或病人死亡的临床恶化风险降低有关。

 

 

原始出处:

Daniel E. Freedberg. Et al. Famotidine Use Is Associated With Improved Clinical Outcomes in Hospitalized COVID-19 Patients: A Propensity Score Matched Retrospective Cohort Study. Gastroenterology.2020.

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    2020-11-18 许安
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    2020-09-25 易水河

    应该是减少了应激性溃疡的风险

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