Dig Dis Sci:回结肠切除术后吻合口溃疡可以预测克罗恩病术后复发

2020-10-05 MedSci原创 MedSci原创

大多数克罗恩病(CD)的患者在其一生中需要接受一次手术治疗,手术可有效缓解疾病的发展,回盲切除术是最常见的手术方法之一。

         大多数克罗恩病(CD)的患者在其一生中需要接受一次手术治疗,手术可有效缓解疾病的发展,回盲切除术是最常见的手术方法之一。可是由于CD的性质,根治性切除术后术后复发是常见的。大约70%CD患者在手术后的第一年就会出现复发症状。因此,CD术后复发的预测对于防止再次行肠切除术和维持患者的生活质量很重要。Rutgeerts评分通常用于预测回肠切除术后CD患者的术后复发。但是目前对吻合口溃疡(AUs)的预测效果还具有争议,本项研究旨在调查术后克罗恩病(CD)患者的吻合口溃疡(AUs)与内镜复发之间的关联。

 

          本项研究纳入了2000年至2016年间回盲切除后1年内首次进行回肠结肠镜检查的CD术后患者,对所有患者均进行了内镜检查。主要观察结果是AU在预测内镜复发中的作用。

 

 

           在116例接受术后结肠镜检查的Rutgeerts为i0至i1的内镜缓解患者中,有84.5%(98/116)接受了随后的回肠结肠镜检查。在首次回肠结肠镜检查后的中位随访30.0个月之间,有56.1%(55/98)的患者出现内镜复发。此外,AUs占65.8%(48/73),在多变量分析中,AU([aHR]为4.33; 95%置信区间[CI]为1.87-10.0;P  <0.001)与内镜复发有关。

 

         因此,本项研究已经证实在有内镜缓解的术后CD患者中,AUs与内镜复发的高风险相关。

 

原始出处:

Jin Yong Kim. Et al. The Clinical Significance of Anastomotic Ulcers After Ileocolic Resection to Predict Postoperative Recurrence of Crohn’s Disease. Digestive Diseases and Sciences.2020.

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