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欧洲委员会（EC）批准CRYSVITA（burosumab）治疗老年人和成年人X连锁性低磷血症（XLH）

2020-10-03 Allan MedSci原创

CrysvitaBurosumabX连锁性低磷血症XLH
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日本协和麒麟有限公司近日宣布，欧洲委员会（EC）已批准CRYSVITA（burosumab）用于老年人和成年人X连锁性低磷血症（XLH）。

日本协和麒麟有限公司近日宣布，欧洲委员会（EC）已批准CRYSVITA®（burosumab）用于老年人和成年人X连锁性低磷血症（XLH）。CRYSVITA先前已被批准用于具有X射线影像学证据、1岁以上XLH儿童和青少年患者。有了这一扩大的批准，所有具有放射学影像学骨病证据的青少年和成人，无论其生长状况如何，均有资格接受CRYSVITA治疗。

X连锁性低磷血症（XLH）是一种终生性进行性疾病，通常出现在儿童时期，会导致下肢畸形，发育迟缓以及骨骼和关节疼痛。诸如脓肿、骨关节炎、关节病（肌腱问题）和听力下降等症状成年后可能也会出现。由于这种疾病，一些成年人可能需要特殊的设备来改善其活动能力。

法国巴黎HôpitalCochin的Karine Briot博士说：“到现在为止，对于这种进行性的致残性疾病只有有限的治疗选择。今天的批准是重要的进步，因为这意味着这些成年XLH患者首次有了治疗选择”。

 

原始出处：

https://www.firstwordpharma.com/node/1762542?tsid=4

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    2021-09-06 snf701207

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    2020-12-31 ms2999106592497887

    #欧洲委员会#

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    2021-01-16 fyxzlh

    #Crysvita#

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createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83erCiat0j36p5MejdM9yCLtcVcY8WS5VIKuCMqXFNs56U6iacZib5CJvh6mVxGERicM6ZAkl91jMgpcDrw/132, createdBy=37622500012, createdName=ms2999106592497887, createdTime=Thu Dec 31 19:31:37 CST 2020, time=2020-12-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1634191, encodeId=d99b163419173, content=<a href='/topic/show?id=e487530404' target=_blank style='color:#2F92EE;'>#Crysvita#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5304, encryptionId=e487530404, topicName=Crysvita)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ef6c22086732, createdName=fyxzlh, createdTime=Sat Jan 16 22:31:37 CST 2021, time=2021-01-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1668806, encodeId=48e3166880647, content=<a href='/topic/show?id=3aad3e9530' target=_blank style='color:#2F92EE;'>#Burosumab#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=18, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3795, encryptionId=3aad3e9530, topicName=Burosumab)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7db326440501, createdName=xuqianhua, createdTime=Mon May 17 03:31:37 CST 2021, time=2021-05-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2036553, encodeId=ba6d2036553ae, content=<a href='/topic/show?id=d50b1892341' target=_blank style='color:#2F92EE;'>#X连锁性低磷血症#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=18923, encryptionId=d50b1892341, topicName=X连锁性低磷血症)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c859411, createdName=hmwwww, createdTime=Mon Mar 29 22:31:37 CST 2021, time=2021-03-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1665440, encodeId=929c166544046, content=<a href='/topic/show?id=f6fd1891e53' target=_blank style='color:#2F92EE;'>#X连锁#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=18917, encryptionId=f6fd1891e53, topicName=X连锁)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=bdb025960146, createdName=12498ebem27暂无昵称, createdTime=Tue Feb 23 02:31:37 CST 2021, time=2021-02-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1339353, encodeId=21e61339353fe, content=<a href='/topic/show?id=447663054f5' target=_blank style='color:#2F92EE;'>#欧洲#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=63054, encryptionId=447663054f5, topicName=欧洲)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/PiajxSqBRaEKxsKDoOOFxGpMibw6lsQFUIicWt7kWGevkdgFhjiban1icD2JdIBmjVo7qX7aSlCSpiaia382nuLKiaI3Cg/132, createdBy=5c442500150, createdName=ms9474365431325850, createdTime=Mon Oct 05 01:31:37 CST 2020, time=2020-10-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1364661, encodeId=02231364661e4, content=<a href='/topic/show?id=7c5615628ad' target=_blank style='color:#2F92EE;'>#ROS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15628, encryptionId=7c5615628ad, topicName=ROS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=acc3210, createdName=lsndxfj, createdTime=Mon Oct 05 01:31:37 CST 2020, time=2020-10-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1531012, encodeId=2ad91531012bf, content=<a href='/topic/show?id=e80b26301b6' target=_blank style='color:#2F92EE;'>#低磷血症#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=26301, encryptionId=e80b26301b6, topicName=低磷血症)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f7f312187038, createdName=medscijoin, createdTime=Mon Oct 05 01:31:37 CST 2020, time=2020-10-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=889889, encodeId=890a889889ae, content=积分, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=eb375423293, createdName=ms3000001299858649, createdTime=Sat Oct 03 13:32:24 CST 2020, time=2020-10-03, status=1, ipAttribution=)]
    2021-05-17 xuqianhua

    #Burosumab#

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1912450, encodeId=4b181912450da, content=<a href='/topic/show?id=4de7112046c' target=_blank style='color:#2F92EE;'>#mAb#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11204, encryptionId=4de7112046c, topicName=mAb)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=25e7304, createdName=snf701207, createdTime=Mon Sep 06 10:31:37 CST 2021, time=2021-09-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2019423, encodeId=08e32019423cb, content=<a href='/topic/show?id=fb11630689a' target=_blank style='color:#2F92EE;'>#欧洲委员会#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=63068, encryptionId=fb11630689a, topicName=欧洲委员会)], attachment=null, authenticateStatus=null, 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style='color:#2F92EE;'>#Burosumab#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=18, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3795, encryptionId=3aad3e9530, topicName=Burosumab)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7db326440501, createdName=xuqianhua, createdTime=Mon May 17 03:31:37 CST 2021, time=2021-05-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2036553, encodeId=ba6d2036553ae, content=<a href='/topic/show?id=d50b1892341' target=_blank style='color:#2F92EE;'>#X连锁性低磷血症#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=18923, encryptionId=d50b1892341, topicName=X连锁性低磷血症)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c859411, createdName=hmwwww, createdTime=Mon Mar 29 22:31:37 CST 2021, time=2021-03-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1665440, encodeId=929c166544046, content=<a href='/topic/show?id=f6fd1891e53' target=_blank style='color:#2F92EE;'>#X连锁#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=18917, encryptionId=f6fd1891e53, topicName=X连锁)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=bdb025960146, createdName=12498ebem27暂无昵称, createdTime=Tue Feb 23 02:31:37 CST 2021, time=2021-02-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1339353, encodeId=21e61339353fe, content=<a href='/topic/show?id=447663054f5' target=_blank style='color:#2F92EE;'>#欧洲#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=63054, encryptionId=447663054f5, topicName=欧洲)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/PiajxSqBRaEKxsKDoOOFxGpMibw6lsQFUIicWt7kWGevkdgFhjiban1icD2JdIBmjVo7qX7aSlCSpiaia382nuLKiaI3Cg/132, createdBy=5c442500150, createdName=ms9474365431325850, createdTime=Mon Oct 05 01:31:37 CST 2020, time=2020-10-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1364661, encodeId=02231364661e4, content=<a href='/topic/show?id=7c5615628ad' target=_blank style='color:#2F92EE;'>#ROS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15628, encryptionId=7c5615628ad, topicName=ROS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=acc3210, createdName=lsndxfj, createdTime=Mon Oct 05 01:31:37 CST 2020, time=2020-10-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1531012, encodeId=2ad91531012bf, content=<a href='/topic/show?id=e80b26301b6' target=_blank style='color:#2F92EE;'>#低磷血症#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=26301, encryptionId=e80b26301b6, topicName=低磷血症)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f7f312187038, createdName=medscijoin, createdTime=Mon Oct 05 01:31:37 CST 2020, time=2020-10-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=889889, encodeId=890a889889ae, content=积分, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=eb375423293, createdName=ms3000001299858649, createdTime=Sat Oct 03 13:32:24 CST 2020, time=2020-10-03, status=1, ipAttribution=)]
    2021-03-29 hmwwww

    #X连锁性低磷血症#

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1912450, encodeId=4b181912450da, content=<a href='/topic/show?id=4de7112046c' target=_blank style='color:#2F92EE;'>#mAb#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11204, encryptionId=4de7112046c, topicName=mAb)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=25e7304, createdName=snf701207, createdTime=Mon Sep 06 10:31:37 CST 2021, time=2021-09-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2019423, encodeId=08e32019423cb, content=<a href='/topic/show?id=fb11630689a' target=_blank style='color:#2F92EE;'>#欧洲委员会#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=63068, encryptionId=fb11630689a, topicName=欧洲委员会)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83erCiat0j36p5MejdM9yCLtcVcY8WS5VIKuCMqXFNs56U6iacZib5CJvh6mVxGERicM6ZAkl91jMgpcDrw/132, createdBy=37622500012, createdName=ms2999106592497887, createdTime=Thu Dec 31 19:31:37 CST 2020, time=2020-12-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1634191, encodeId=d99b163419173, content=<a href='/topic/show?id=e487530404' target=_blank style='color:#2F92EE;'>#Crysvita#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5304, encryptionId=e487530404, topicName=Crysvita)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ef6c22086732, createdName=fyxzlh, createdTime=Sat Jan 16 22:31:37 CST 2021, time=2021-01-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1668806, encodeId=48e3166880647, content=<a href='/topic/show?id=3aad3e9530' target=_blank style='color:#2F92EE;'>#Burosumab#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=18, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3795, encryptionId=3aad3e9530, topicName=Burosumab)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7db326440501, createdName=xuqianhua, createdTime=Mon May 17 03:31:37 CST 2021, time=2021-05-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2036553, encodeId=ba6d2036553ae, content=<a href='/topic/show?id=d50b1892341' target=_blank style='color:#2F92EE;'>#X连锁性低磷血症#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=18923, encryptionId=d50b1892341, topicName=X连锁性低磷血症)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c859411, createdName=hmwwww, createdTime=Mon Mar 29 22:31:37 CST 2021, time=2021-03-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1665440, encodeId=929c166544046, content=<a href='/topic/show?id=f6fd1891e53' target=_blank style='color:#2F92EE;'>#X连锁#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=18917, encryptionId=f6fd1891e53, topicName=X连锁)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=bdb025960146, createdName=12498ebem27暂无昵称, createdTime=Tue Feb 23 02:31:37 CST 2021, time=2021-02-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1339353, encodeId=21e61339353fe, content=<a href='/topic/show?id=447663054f5' target=_blank style='color:#2F92EE;'>#欧洲#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=63054, encryptionId=447663054f5, topicName=欧洲)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/PiajxSqBRaEKxsKDoOOFxGpMibw6lsQFUIicWt7kWGevkdgFhjiban1icD2JdIBmjVo7qX7aSlCSpiaia382nuLKiaI3Cg/132, createdBy=5c442500150, createdName=ms9474365431325850, createdTime=Mon Oct 05 01:31:37 CST 2020, time=2020-10-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1364661, encodeId=02231364661e4, content=<a href='/topic/show?id=7c5615628ad' target=_blank style='color:#2F92EE;'>#ROS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15628, encryptionId=7c5615628ad, topicName=ROS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=acc3210, createdName=lsndxfj, createdTime=Mon Oct 05 01:31:37 CST 2020, time=2020-10-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1531012, encodeId=2ad91531012bf, content=<a href='/topic/show?id=e80b26301b6' target=_blank style='color:#2F92EE;'>#低磷血症#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=26301, encryptionId=e80b26301b6, topicName=低磷血症)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f7f312187038, createdName=medscijoin, createdTime=Mon Oct 05 01:31:37 CST 2020, time=2020-10-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=889889, encodeId=890a889889ae, content=积分, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=eb375423293, createdName=ms3000001299858649, createdTime=Sat Oct 03 13:32:24 CST 2020, time=2020-10-03, status=1, ipAttribution=)]
    2021-02-23 12498ebem27暂无昵称

    #X连锁#

    0

  7. 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createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83erCiat0j36p5MejdM9yCLtcVcY8WS5VIKuCMqXFNs56U6iacZib5CJvh6mVxGERicM6ZAkl91jMgpcDrw/132, createdBy=37622500012, createdName=ms2999106592497887, createdTime=Thu Dec 31 19:31:37 CST 2020, time=2020-12-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1634191, encodeId=d99b163419173, content=<a href='/topic/show?id=e487530404' target=_blank style='color:#2F92EE;'>#Crysvita#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5304, encryptionId=e487530404, topicName=Crysvita)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ef6c22086732, createdName=fyxzlh, createdTime=Sat Jan 16 22:31:37 CST 2021, time=2021-01-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1668806, encodeId=48e3166880647, content=<a href='/topic/show?id=3aad3e9530' target=_blank style='color:#2F92EE;'>#Burosumab#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=18, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3795, encryptionId=3aad3e9530, topicName=Burosumab)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7db326440501, createdName=xuqianhua, createdTime=Mon May 17 03:31:37 CST 2021, time=2021-05-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2036553, encodeId=ba6d2036553ae, content=<a href='/topic/show?id=d50b1892341' target=_blank style='color:#2F92EE;'>#X连锁性低磷血症#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=18923, encryptionId=d50b1892341, topicName=X连锁性低磷血症)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c859411, createdName=hmwwww, createdTime=Mon Mar 29 22:31:37 CST 2021, time=2021-03-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1665440, encodeId=929c166544046, content=<a href='/topic/show?id=f6fd1891e53' target=_blank style='color:#2F92EE;'>#X连锁#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=18917, encryptionId=f6fd1891e53, topicName=X连锁)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=bdb025960146, createdName=12498ebem27暂无昵称, createdTime=Tue Feb 23 02:31:37 CST 2021, time=2021-02-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1339353, encodeId=21e61339353fe, content=<a href='/topic/show?id=447663054f5' target=_blank style='color:#2F92EE;'>#欧洲#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=63054, encryptionId=447663054f5, topicName=欧洲)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/PiajxSqBRaEKxsKDoOOFxGpMibw6lsQFUIicWt7kWGevkdgFhjiban1icD2JdIBmjVo7qX7aSlCSpiaia382nuLKiaI3Cg/132, createdBy=5c442500150, createdName=ms9474365431325850, createdTime=Mon Oct 05 01:31:37 CST 2020, time=2020-10-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1364661, encodeId=02231364661e4, content=<a href='/topic/show?id=7c5615628ad' target=_blank style='color:#2F92EE;'>#ROS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15628, encryptionId=7c5615628ad, topicName=ROS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=acc3210, createdName=lsndxfj, createdTime=Mon Oct 05 01:31:37 CST 2020, time=2020-10-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1531012, encodeId=2ad91531012bf, content=<a href='/topic/show?id=e80b26301b6' target=_blank style='color:#2F92EE;'>#低磷血症#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=26301, encryptionId=e80b26301b6, topicName=低磷血症)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f7f312187038, createdName=medscijoin, createdTime=Mon Oct 05 01:31:37 CST 2020, time=2020-10-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=889889, encodeId=890a889889ae, content=积分, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=eb375423293, createdName=ms3000001299858649, createdTime=Sat Oct 03 13:32:24 CST 2020, time=2020-10-03, status=1, ipAttribution=)]
    2020-10-05 ms9474365431325850

    #欧洲#

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=1912450, encodeId=4b181912450da, content=<a href='/topic/show?id=4de7112046c' target=_blank style='color:#2F92EE;'>#mAb#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11204, encryptionId=4de7112046c, topicName=mAb)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=25e7304, createdName=snf701207, createdTime=Mon Sep 06 10:31:37 CST 2021, time=2021-09-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2019423, encodeId=08e32019423cb, content=<a href='/topic/show?id=fb11630689a' target=_blank style='color:#2F92EE;'>#欧洲委员会#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=63068, encryptionId=fb11630689a, topicName=欧洲委员会)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83erCiat0j36p5MejdM9yCLtcVcY8WS5VIKuCMqXFNs56U6iacZib5CJvh6mVxGERicM6ZAkl91jMgpcDrw/132, createdBy=37622500012, createdName=ms2999106592497887, createdTime=Thu Dec 31 19:31:37 CST 2020, time=2020-12-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1634191, encodeId=d99b163419173, content=<a href='/topic/show?id=e487530404' target=_blank style='color:#2F92EE;'>#Crysvita#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5304, encryptionId=e487530404, topicName=Crysvita)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ef6c22086732, createdName=fyxzlh, createdTime=Sat Jan 16 22:31:37 CST 2021, time=2021-01-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1668806, encodeId=48e3166880647, content=<a href='/topic/show?id=3aad3e9530' target=_blank style='color:#2F92EE;'>#Burosumab#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=18, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3795, encryptionId=3aad3e9530, topicName=Burosumab)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7db326440501, createdName=xuqianhua, createdTime=Mon May 17 03:31:37 CST 2021, time=2021-05-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2036553, encodeId=ba6d2036553ae, content=<a href='/topic/show?id=d50b1892341' target=_blank style='color:#2F92EE;'>#X连锁性低磷血症#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=18923, encryptionId=d50b1892341, topicName=X连锁性低磷血症)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c859411, createdName=hmwwww, createdTime=Mon Mar 29 22:31:37 CST 2021, time=2021-03-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1665440, encodeId=929c166544046, content=<a href='/topic/show?id=f6fd1891e53' target=_blank style='color:#2F92EE;'>#X连锁#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=18917, encryptionId=f6fd1891e53, topicName=X连锁)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=bdb025960146, createdName=12498ebem27暂无昵称, createdTime=Tue Feb 23 02:31:37 CST 2021, time=2021-02-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1339353, encodeId=21e61339353fe, content=<a href='/topic/show?id=447663054f5' target=_blank style='color:#2F92EE;'>#欧洲#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=63054, encryptionId=447663054f5, topicName=欧洲)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/PiajxSqBRaEKxsKDoOOFxGpMibw6lsQFUIicWt7kWGevkdgFhjiban1icD2JdIBmjVo7qX7aSlCSpiaia382nuLKiaI3Cg/132, createdBy=5c442500150, createdName=ms9474365431325850, createdTime=Mon Oct 05 01:31:37 CST 2020, time=2020-10-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1364661, encodeId=02231364661e4, content=<a href='/topic/show?id=7c5615628ad' target=_blank style='color:#2F92EE;'>#ROS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15628, encryptionId=7c5615628ad, topicName=ROS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=acc3210, createdName=lsndxfj, createdTime=Mon Oct 05 01:31:37 CST 2020, time=2020-10-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1531012, encodeId=2ad91531012bf, content=<a href='/topic/show?id=e80b26301b6' target=_blank style='color:#2F92EE;'>#低磷血症#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=26301, encryptionId=e80b26301b6, topicName=低磷血症)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f7f312187038, createdName=medscijoin, createdTime=Mon Oct 05 01:31:37 CST 2020, time=2020-10-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=889889, encodeId=890a889889ae, content=积分, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=eb375423293, createdName=ms3000001299858649, createdTime=Sat Oct 03 13:32:24 CST 2020, time=2020-10-03, status=1, ipAttribution=)]
    2020-10-05 lsndxfj

    #ROS#

    0

  9. [GetPortalCommentsPageByObjectIdResponse(id=1912450, encodeId=4b181912450da, content=<a href='/topic/show?id=4de7112046c' target=_blank style='color:#2F92EE;'>#mAb#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11204, encryptionId=4de7112046c, topicName=mAb)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=25e7304, createdName=snf701207, createdTime=Mon Sep 06 10:31:37 CST 2021, time=2021-09-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2019423, encodeId=08e32019423cb, content=<a href='/topic/show?id=fb11630689a' target=_blank style='color:#2F92EE;'>#欧洲委员会#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=63068, encryptionId=fb11630689a, topicName=欧洲委员会)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83erCiat0j36p5MejdM9yCLtcVcY8WS5VIKuCMqXFNs56U6iacZib5CJvh6mVxGERicM6ZAkl91jMgpcDrw/132, createdBy=37622500012, createdName=ms2999106592497887, createdTime=Thu Dec 31 19:31:37 CST 2020, time=2020-12-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1634191, encodeId=d99b163419173, content=<a href='/topic/show?id=e487530404' target=_blank style='color:#2F92EE;'>#Crysvita#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5304, encryptionId=e487530404, topicName=Crysvita)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ef6c22086732, createdName=fyxzlh, createdTime=Sat Jan 16 22:31:37 CST 2021, time=2021-01-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1668806, encodeId=48e3166880647, content=<a href='/topic/show?id=3aad3e9530' target=_blank style='color:#2F92EE;'>#Burosumab#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=18, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3795, encryptionId=3aad3e9530, topicName=Burosumab)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7db326440501, createdName=xuqianhua, createdTime=Mon May 17 03:31:37 CST 2021, time=2021-05-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2036553, encodeId=ba6d2036553ae, content=<a href='/topic/show?id=d50b1892341' target=_blank style='color:#2F92EE;'>#X连锁性低磷血症#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=18923, encryptionId=d50b1892341, topicName=X连锁性低磷血症)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c859411, createdName=hmwwww, createdTime=Mon Mar 29 22:31:37 CST 2021, time=2021-03-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1665440, encodeId=929c166544046, content=<a href='/topic/show?id=f6fd1891e53' target=_blank style='color:#2F92EE;'>#X连锁#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=18917, encryptionId=f6fd1891e53, topicName=X连锁)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=bdb025960146, createdName=12498ebem27暂无昵称, createdTime=Tue Feb 23 02:31:37 CST 2021, time=2021-02-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1339353, encodeId=21e61339353fe, content=<a href='/topic/show?id=447663054f5' target=_blank style='color:#2F92EE;'>#欧洲#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=63054, encryptionId=447663054f5, topicName=欧洲)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/PiajxSqBRaEKxsKDoOOFxGpMibw6lsQFUIicWt7kWGevkdgFhjiban1icD2JdIBmjVo7qX7aSlCSpiaia382nuLKiaI3Cg/132, createdBy=5c442500150, createdName=ms9474365431325850, createdTime=Mon Oct 05 01:31:37 CST 2020, time=2020-10-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1364661, encodeId=02231364661e4, content=<a href='/topic/show?id=7c5615628ad' target=_blank style='color:#2F92EE;'>#ROS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15628, encryptionId=7c5615628ad, topicName=ROS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=acc3210, createdName=lsndxfj, createdTime=Mon Oct 05 01:31:37 CST 2020, time=2020-10-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1531012, encodeId=2ad91531012bf, content=<a href='/topic/show?id=e80b26301b6' target=_blank style='color:#2F92EE;'>#低磷血症#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=26301, encryptionId=e80b26301b6, topicName=低磷血症)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f7f312187038, createdName=medscijoin, createdTime=Mon Oct 05 01:31:37 CST 2020, time=2020-10-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=889889, encodeId=890a889889ae, content=积分, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=eb375423293, createdName=ms3000001299858649, createdTime=Sat Oct 03 13:32:24 CST 2020, time=2020-10-03, status=1, ipAttribution=)]
    2020-10-05 medscijoin

    #低磷血症#

    0

  10. [GetPortalCommentsPageByObjectIdResponse(id=1912450, encodeId=4b181912450da, content=<a href='/topic/show?id=4de7112046c' target=_blank style='color:#2F92EE;'>#mAb#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11204, encryptionId=4de7112046c, topicName=mAb)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=25e7304, createdName=snf701207, createdTime=Mon Sep 06 10:31:37 CST 2021, time=2021-09-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2019423, encodeId=08e32019423cb, content=<a href='/topic/show?id=fb11630689a' target=_blank style='color:#2F92EE;'>#欧洲委员会#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=63068, encryptionId=fb11630689a, topicName=欧洲委员会)], attachment=null, authenticateStatus=null, 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    2020-10-03 ms3000001299858649

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