Metabolism:DPP-4抑制剂在2型糖尿病治疗中的疗效和安全性

2020-06-17 MedSci原创 MedSci原创

心血管结局试验已证明采用西他列汀、沙格列汀、阿格列汀、利那列汀和维达列汀治疗的患者对于缺血性事件具有心血管安全性。研究显示沙格列汀治疗的患者住院率增加的数据似乎不是药物类别的效应。

在2型糖尿病的治疗指南中,建议将属于肠降血糖素药物的二肽基肽酶4抑制剂(DPP-4is)作为二线或三线疗法。与其他降糖药相比,它们具有良好的药物耐受性和安全性。

近日,代谢性疾病领域权威杂志Metabolism-Clinical and Experimental上发表了一篇研究文章,这项研究旨在讨论DPP-4is使用及其血管状况的数据,并就安全性和有效性与其他口服降糖药进行了比较。该评价纳入了当前可用的原始研究、摘要、评论文章、系统评价和荟萃分析。

DPP4is单药治疗可有效降低HbA1c水平0.5%,与其他药物联合治疗可降低1.0%。与其他降糖药相比,它们具有良好的耐受性和安全性。但是,可能存在与急性胰腺炎和胰腺癌有关的风险。

迄今为止,心血管结局试验已证明采用西他列汀、沙格列汀、阿格列汀、利那列汀和维达列汀治疗的患者对于缺血性事件具有心血管安全性。研究显示沙格列汀治疗的患者住院率增加的数据似乎不是药物类别的效应。

原始出处:

Anca Pantea Stoian,et al.The efficacy and safety of Dipeptyl Peptidase-4 inhibitors compared to other Oral glucose-lowering medications in the treatment of type 2 diabetes.Metabolism-Clinical and Experimental.2020.https://www.metabolismjournal.com/article/S0026-0495(20)30159-1/fulltext

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    2021-05-08 jklm09
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    2020-09-26 一闲
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  5. 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  6. [GetPortalCommentsPageByObjectIdResponse(id=1852407, encodeId=a537185240e8a, content=<a href='/topic/show?id=f0a254918f0' target=_blank style='color:#2F92EE;'>#抑制剂#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54918, encryptionId=f0a254918f0, topicName=抑制剂)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=44a360, createdName=jklm09, createdTime=Sat May 08 03:41:48 CST 2021, time=2021-05-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1896680, encodeId=8ffa189668069, content=<a href='/topic/show?id=4a391158248' target=_blank style='color:#2F92EE;'>#MET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11582, encryptionId=4a391158248, topicName=MET)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=18fc139, 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href='/topic/show?id=7ff0621125' target=_blank style='color:#2F92EE;'>#DPP-4#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6211, encryptionId=7ff0621125, topicName=DPP-4)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJmFzSicR3biaepTGaMtOl8hS8SjNQ92YP4GmFUlefPkcPnZJWBsHM057ogFrQEPrgdTgPrlxG70KYA/132, createdBy=eeb42370314, createdName=gaoxiaoe, createdTime=Fri Jun 19 12:41:48 CST 2020, time=2020-06-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1577228, encodeId=b3bd15e722807, content=<a href='/topic/show?id=d86d1159e36' target=_blank style='color:#2F92EE;'>#Metabolism#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11597, encryptionId=d86d1159e36, topicName=Metabolism)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1a6516392333, createdName=1249859em43(暂无昵称), createdTime=Fri Jun 19 12:41:48 CST 2020, time=2020-06-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1598062, encodeId=64701598062db, content=<a href='/topic/show?id=6c6f1e62c5' target=_blank style='color:#2F92EE;'>#ABO#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1762, encryptionId=6c6f1e62c5, topicName=ABO)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b6c918580135, createdName=闆锋旦, createdTime=Fri Jun 19 12:41:48 CST 2020, time=2020-06-19, status=1, ipAttribution=)]
    2020-12-02 guojianrong
  7. 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  8. 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href='/topic/show?id=7ff0621125' target=_blank style='color:#2F92EE;'>#DPP-4#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6211, encryptionId=7ff0621125, topicName=DPP-4)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJmFzSicR3biaepTGaMtOl8hS8SjNQ92YP4GmFUlefPkcPnZJWBsHM057ogFrQEPrgdTgPrlxG70KYA/132, createdBy=eeb42370314, createdName=gaoxiaoe, createdTime=Fri Jun 19 12:41:48 CST 2020, time=2020-06-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1577228, encodeId=b3bd15e722807, content=<a href='/topic/show?id=d86d1159e36' target=_blank style='color:#2F92EE;'>#Metabolism#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11597, encryptionId=d86d1159e36, topicName=Metabolism)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1a6516392333, createdName=1249859em43(暂无昵称), createdTime=Fri Jun 19 12:41:48 CST 2020, time=2020-06-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1598062, encodeId=64701598062db, content=<a href='/topic/show?id=6c6f1e62c5' target=_blank style='color:#2F92EE;'>#ABO#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1762, encryptionId=6c6f1e62c5, topicName=ABO)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b6c918580135, createdName=闆锋旦, createdTime=Fri Jun 19 12:41:48 CST 2020, time=2020-06-19, status=1, ipAttribution=)]
    2020-06-19 gaoxiaoe
  9. 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  10. 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authenticateStatus=null, createdAvatar=null, createdBy=1a6516392333, createdName=1249859em43(暂无昵称), createdTime=Fri Jun 19 12:41:48 CST 2020, time=2020-06-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1598062, encodeId=64701598062db, content=<a href='/topic/show?id=6c6f1e62c5' target=_blank style='color:#2F92EE;'>#ABO#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1762, encryptionId=6c6f1e62c5, topicName=ABO)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b6c918580135, createdName=闆锋旦, createdTime=Fri Jun 19 12:41:48 CST 2020, time=2020-06-19, status=1, ipAttribution=)]
    2020-06-19 闆锋旦

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这项研究表明,ACHD导管介入治疗的复杂性不断增加,病种不断扩大,而这与主要并发症的发生率低、住院时间短和早中期死亡率低相关。

Ann Rheum Dis:卡那单抗治疗成人Still病的II期试验

使用卡那单抗治疗可改善AOSD的几种预后指标。总体安全性研究结果与卡那单抗已知的特征一致。

Ann Rheum Dis:苏金单抗对难治性白塞病黏膜和关节表型的长期疗效和安全性

对于既往治疗耐药的白塞病黏膜和关节表型患者,使用每月150mg和300mg的苏金单抗进行长期治疗是安全有效的。

Arthritis Rheumatol:新型JAK3/TEC抑制剂PF-06651600(ritlecitinib)对中重度类风湿性关节炎的疗效和安全性

口服JAK3/TEC抑制剂PF-06651600(200mg QD)与RA疾病活动性显著改善相关,并且耐受性良好。