J Clin Endocrinol Metab:研究表明,肠道菌群与肥胖、心血管疾病和2型糖尿病有关

2018-02-27 佚名 Medicalxpress

研究人员发现了肠道细菌和肥胖之间的新关系。他们发现血液中的某些氨基酸与肥胖和肠道菌群的组成有关。

研究人员发现了肠道细菌和肥胖之间的新关系。他们发现血液中的某些氨基酸与肥胖和肠道菌群的组成有关。

研究人员对微生物群落的重要性的了解,要少于对这一主题的报道。很多关于这个主题的研究都是基于动物研究,而这些研究不能直接应用于人类。另外,一个人的健康肠道菌群不一定对其他人有好处。

然而,越来越多的研究表明肠道菌群确实在健康中扮演着重要的角色。它影响新陈代谢,可能与肥胖、心血管疾病和2型糖尿病有关。

先前的研究表明,患有这些疾病的人的代谢物发生了变化。在血液中,小分子或代谢残留物。因此,这项新研究的目的是确定血液中与肥胖有关的代谢物,并研究这些与肥胖有关的代谢物是否影响粪便样本中细菌菌群的组成。

研究人员分析了674名Malmo后代研究中的血浆和粪便样本。他们发现19种代谢物可能与人的身体质量指数有关;谷氨酸和所谓的BCAA(支链和芳香氨基酸)与肥胖有着最紧密的联系。他们还发现,与肥胖相关的代谢物与4个肠道细菌有关。

“BMI的差异很大程度上是由谷氨酸和BCAA水平的差异来解释的。这表明,代谢物和肠道细菌相互作用,而不是相互独立,”隆德大学的遗传流行病学教授Marju Orho-Melander说。

到目前为止,研究中最强烈的肥胖风险因素是谷氨酸,在之前的研究中与肥胖有关,而BCAA被用于预测2型糖尿病和心血管疾病的未来发病。

Marju orhomelander说:“这意味着未来的研究应该更多地关注如何改变肠道细菌的组成,以减少肥胖和相关代谢性疾病和心血管疾病的风险。”为了达到这个目的,我们首先需要了解健康的正常肠道菌群是什么样子的,以及哪些因素会影响细菌组成。这需要大量的人口研究,以及干预研究。

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    2019-01-22 guojianrong
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    2019-01-10 一闲
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    2018-02-28 121832a9m88暂无昵称

    学习了

    0

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