Int Forum Allergy Rhinol:类胆碱能神经元D-U87细胞能估促进过敏性鼻炎T辅助细胞2的极化

2019-11-09 AlexYang MedSci原创

副交感神经过敏对过敏性鼻炎(AR)的严重度是有贡献的,但是潜在的神经免疫调控的精细机制仍旧不清楚。最近,有研究人员调查了胆碱能神经抑制剂对AR CD4+ T辅助细胞2(Th2)的极化的影响以及潜在的调控机制。研究人员建立了体外D-U87细胞和CD4+ T细胞的共培养模型。研究发现,Th2细胞比例在来源于AR患者的CD4+ T细胞与D-U87细胞共培养后显著增加,但是在异丙托溴铵(IB)处理后减少。

副交感神经过敏对过敏性鼻炎(AR)的严重度是有贡献的,但是潜在的神经免疫调控的精细机制仍旧不清楚。最近,有研究人员调查了胆碱能神经抑制剂对AR CD4+ T辅助细胞2(Th2)的极化的影响以及潜在的调控机制。

研究人员建立了体外D-U87细胞和CD4+ T细胞的共培养模型。研究发现,Th2细胞比例在来源于AR患者的CD4+ T细胞与D-U87细胞共培养后显著增加,但是在异丙托溴铵(IB)处理后减少。与之相反,Th1细胞比例在对照CD4+ T细胞与D-U87细胞共培养后显著增加,但是IB处理并未产生影响。更多的是,与D-U87细胞共培养后,磷酸化Akt(p-Akt)蛋白水平能够增加在来源于对照和AR患者的CD4+ T细胞中增加,而在IB处理后水平减少。然鹅日, p-Akt水平在来源于AR患者的细胞中比对照更高。更多的是,Akt抑制能够减少AR患者中Th2细胞的比例。

最后,研究人员指出,体外胆碱能神经抑制剂IB处理能够减少AR CD4+ T细胞的极化为Th2细胞,其中部分的通过Akt依赖的机制实现。

原始出处:

Liu H, Wang T, Xia J et al. Cholinergic neuron-like D-U87 cells promote polarization of allergic rhinitis T-helper 2 cells. Int Forum Allergy Rhinol. 28 Oct 2019

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    2019-11-11 膀胱癌
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    2019-11-11 grace5704

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