JAHA:HIV感染者冠状动脉钙化和斑块特征

2021-09-29 MedSci原创 MedSci原创

与HIV阴性个体相比,HIV感染者的非钙化冠状动脉斑块患病率更高,冠状动脉钙化患病率相似。未来对冠状动脉钙化和斑块进展的研究可以进一步阐明HIV感染者的亚临床动脉粥样硬化。

研究报告称,艾滋病毒感染者具有较高的亚临床血管疾病负担,但数据没有充分综合。

近日,心血管疾病领域权威杂志JAHA上发表了一篇研究文章,研究人员对HIV感染者冠状动脉钙化和冠状动脉斑块的研究进行了荟萃分析。

研究人员在电子数据库中进行系统检索,并以标准化形式提取了研究的数据。研究人员使用荟萃分析汇总研究特定的估计值,包括43份报告,27项独特的研究,涉及10867名参与者(6699名HIV阳性,4168名HIV阴性,平均年龄为52岁,86%为男性,32%为黑人)。

与HIV阴性参与者相比,HIV阳性参与者更年轻(平均年龄为49岁 vs. 57岁)并且弗雷明汉风险评分(平均得分为6 vs. 18)较低。对于HIV阳性参与者,冠状动脉钙化评分>0汇总估计值的百分比为45%(95%CI为43%-47%),对于HIV阴性参与者为52%(50%-53%)。在调整了两组之间弗雷明汉风险评分的差异后,这种差异不再显著。HIV阳性与阴性参与者冠状动脉钙化进展的比值比为1.64(95%CI为0.91-2.37)。对于HIV阳性和HIV阴性参与者,非钙化斑块患病率的汇总估计值分别为49%(95%CI为47%-52%)和20%(95%CI为17%–23%)。HIV阳性与阴性参与者的非钙化斑块的比值比为1.23(95%CI为1.08-1.38)。

由此可见,与HIV阴性个体相比,HIV感染者的非钙化冠状动脉斑块患病率更高,冠状动脉钙化患病率相似。未来对冠状动脉钙化和斑块进展的研究可以进一步阐明HIV感染者的亚临床动脉粥样硬化。

原始出处:

Cullen Soares.et al.Coronary Artery Calcification and Plaque Characteristics in People Living With HIV: A Systematic Review and Meta‐Analysis.JAHA.2021.https://www.ahajournals.org/doi/full/10.1161/JAHA.120.019291

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topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210606/e8b96fdba070433da10cd357c0646807/28bf16f46e314caaad8396c0c7df7a04.jpg, createdBy=adb15496357, createdName=仁术2021, createdTime=Thu Sep 30 06:57:30 CST 2021, time=2021-09-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1056298, encodeId=5564105629814, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210706/5924e86cc73c43efb5bad9dd92ac0d7b/63609a5527c447f48b59b39dd248a66f.jpg, createdBy=cf0a5102349, createdName=站在塔尖, createdTime=Wed Sep 29 22:12:19 CST 2021, time=2021-09-29, status=1, ipAttribution=)]
    2021-10-04 1def6e10m76(暂无匿称)

    #冠心病#与HIV阴性个体相比,HIV感染者的非钙化冠状动脉斑块患病率更高,冠状动脉钙化患病率相似。未来对冠状动脉钙化和斑块进展的研究可以进一步阐明HIV感染者的亚临床动脉粥样硬化。

    0

  4. 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createdAvatar=http://thirdqq.qlogo.cn/qqapp/1103841572/B389FA68ECBF51BE2FE14093CF61F6AE/100, createdBy=eb8e2500096, createdName=夏天与十三菇凉, createdTime=Mon Oct 11 12:25:52 CST 2021, time=2021-10-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1057349, encodeId=8d3a105e34959, content=<a href='/topic/show?id=77c33081e40' target=_blank style='color:#2F92EE;'>#冠心病#</a>与HIV阴性个体相比,HIV感染者的非钙化冠状动脉斑块患病率更高,冠状动脉钙化患病率相似。未来对冠状动脉钙化和斑块进展的研究可以进一步阐明HIV感染者的亚临床动脉粥样硬化。, beContent=null, objectType=article, channel=null, level=null, likeNumber=153, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=30817, encryptionId=77c33081e40, topicName=冠心病)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTInOuicIVN8Y32NO4Q53Zpd86ObmNp2WIotichCD0qQHaUBeHj7hgwQBCzX7ce4aEw5ZP8icQQfLH9Zw/132, createdBy=4ec21734756, createdName=1def6e10m76(暂无匿称), createdTime=Mon Oct 04 07:28:13 CST 2021, time=2021-10-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1268639, encodeId=b05b126863962, content=<a href='/topic/show?id=922f21183d' target=_blank style='color:#2F92EE;'>#AHA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2118, encryptionId=922f21183d, topicName=AHA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bf3d82, createdName=zhaohui6731, createdTime=Fri Oct 01 10:25:52 CST 2021, time=2021-10-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1269220, encodeId=892d126922026, content=<a href='/topic/show?id=686830913f7' target=_blank style='color:#2F92EE;'>#冠状动脉钙化#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=30913, encryptionId=686830913f7, topicName=冠状动脉钙化)], attachment=null, authenticateStatus=null, createdAvatar=, 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topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210606/e8b96fdba070433da10cd357c0646807/28bf16f46e314caaad8396c0c7df7a04.jpg, createdBy=adb15496357, createdName=仁术2021, createdTime=Thu Sep 30 06:57:30 CST 2021, time=2021-09-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1056298, encodeId=5564105629814, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210706/5924e86cc73c43efb5bad9dd92ac0d7b/63609a5527c447f48b59b39dd248a66f.jpg, createdBy=cf0a5102349, createdName=站在塔尖, createdTime=Wed Sep 29 22:12:19 CST 2021, time=2021-09-29, status=1, ipAttribution=)]
    2021-10-01 zhaohui6731
  5. 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  6. 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  7. 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  8. 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ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1268639, encodeId=b05b126863962, content=<a href='/topic/show?id=922f21183d' target=_blank style='color:#2F92EE;'>#AHA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2118, encryptionId=922f21183d, topicName=AHA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bf3d82, createdName=zhaohui6731, createdTime=Fri Oct 01 10:25:52 CST 2021, time=2021-10-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1269220, encodeId=892d126922026, content=<a href='/topic/show?id=686830913f7' target=_blank style='color:#2F92EE;'>#冠状动脉钙化#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=30913, encryptionId=686830913f7, topicName=冠状动脉钙化)], attachment=null, authenticateStatus=null, createdAvatar=, 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topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210606/e8b96fdba070433da10cd357c0646807/28bf16f46e314caaad8396c0c7df7a04.jpg, createdBy=adb15496357, createdName=仁术2021, createdTime=Thu Sep 30 06:57:30 CST 2021, time=2021-09-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1056298, encodeId=5564105629814, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210706/5924e86cc73c43efb5bad9dd92ac0d7b/63609a5527c447f48b59b39dd248a66f.jpg, createdBy=cf0a5102349, createdName=站在塔尖, createdTime=Wed Sep 29 22:12:19 CST 2021, time=2021-09-29, status=1, ipAttribution=)]
    2021-09-30 ms8000000025759398

    学习

    0

  9. 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topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210606/e8b96fdba070433da10cd357c0646807/28bf16f46e314caaad8396c0c7df7a04.jpg, createdBy=adb15496357, createdName=仁术2021, createdTime=Thu Sep 30 06:57:30 CST 2021, time=2021-09-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1056298, encodeId=5564105629814, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210706/5924e86cc73c43efb5bad9dd92ac0d7b/63609a5527c447f48b59b39dd248a66f.jpg, createdBy=cf0a5102349, createdName=站在塔尖, createdTime=Wed Sep 29 22:12:19 CST 2021, time=2021-09-29, status=1, ipAttribution=)]
    2021-09-30 仁术2021

    不错,学习了

    0

  10. 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