SCI REP:老年人血清ω-3多不饱和脂肪酸及潜在影响因素!

2018-01-19 xing.T MedSci原创

由此可见,ω-3 PUFAs的血清浓度可能与降低的CAD比例有关,DHA可能是CAD的保护性因素。酒精摄入量和某些药物如PPI可能会降低血清ω-3 PUFA的浓度。

最近的临床试验未能证明补充ω-3多不饱和脂肪酸(PUFA)可减少心血管事件,这与之前的证据相矛盾。然而,这些研究的参与者血清ω-3 PUFA浓度仍不清楚。


近日,Scientific reports杂志上发表了一篇研究文章,研究人员旨在探讨血清ω-3PUFA水平与冠心病(CAD)之间的确切关系,并探讨ω-3PUFA的潜在影响因素。

研究人员选择了多个心血管危险因素或确诊为CAD的中国住院患者(n=460),通过液相色谱质谱法测量了受试者血清中ω-3的PUFAs水平,包括二十碳五烯酸(EPA)和二十二碳六烯酸(DHA)。 CAD患者血清中ω-3 PUFAs浓度低于具有心血管危险因素的患者。此外,调整混杂因素后,血清中DHA高浓度是CAD的独立保护因素(比值比为0.52,P=0.014)。酒精摄入量(P=0.036)和质子泵抑制剂(PPI)使用量(P=0.027)与血清ω-3 PUFA浓度下降有关。

由此可见,ω-3 PUFAs的血清浓度可能与降低的CAD比例有关,DHA可能是CAD的保护性因素。酒精摄入量和某些药物如PPI可能会降低血清ω-3 PUFA的浓度。

原始出处:

Wenwen Liu,et al. Serum ω-3 Polyunsaturated Fatty Acids and Potential Influence Factors in Elderly Patients with Multiple Cardiovascular Risk Factors.Scientific reports.2018. https://www.nature.com/articles/s41598-018-19193-5

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time=2018-01-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=280291, encodeId=ba2c28029181, content=学习了,谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NdgSW0vVibEHQRlKXLlvMibvcHmy5ibwM7Luib2am6ywX6FqBrXibF8k7JVEzriaOSghltmYz1nomRd6TgSp2Yj9xHGAY/0, createdBy=9b2f2045808, createdName=haige, createdTime=Sat Jan 20 09:41:30 CST 2018, time=2018-01-20, status=1, ipAttribution=)]
    2018-01-21 大爰

    学习了谢谢分享!!

    0

  6. 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    2018-01-20 haige

    学习了,谢谢分享!

    0

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