Ultrasound Med Biol:低强度超声辐射可加速骨缺损愈合和再生

2018-10-06 MedSci MedSci原创

本研究旨在评估低强度脉冲超声(LIPUS)诱导的声辐射力对大鼠胫骨模型中骨小梁缺损修复和愈合的影响。 在大鼠的近端双侧胫骨区域(N = 20)产生直径3.5mm的均匀骨缺损。使用LIPUS每天处理左胫骨缺损20min,持续2周。右胫骨的对侧缺损不接受LIPUS治疗,作为对照组。 微型计算机断层扫描显示,LIPUS治疗的胫骨表现出较高的骨量/总体积、连接密度、小梁数和骨矿物质密度,并明显

本研究旨在评估低强度脉冲超声(LIPUS)诱导的声辐射力对大鼠胫骨模型中骨小梁缺损修复和愈合的影响。

在大鼠的近端双侧胫骨区域(N = 20)产生直径3.5mm的均匀骨缺损。使用LIPUS每天处理左胫骨缺损20min,持续2周。右胫骨的对侧缺损不接受LIPUS治疗,作为对照组。

微型计算机断层扫描显示,LIPUS治疗的胫骨表现出较高的骨量/总体积、连接密度、小梁数和骨矿物质密度,并明显降低骨小梁分离。组织形态学分析表明了类似的趋势。机械测试数据显示,与对照组相比,LIPUS治疗明显增加了骨骼僵硬度。短期(2周)LIPUS治疗引起大骨小梁骨缺损的骨小梁骨修复和再生,而皮质骨保持在最初的非矿化阶段。

原始出处:

Liu J, Li X, et al., Acceleration of Bone Defect Healing and Regeneration by Low-Intensity Ultrasound Radiation Force in a Rat Tibial Model. Ultrasound Med Biol. 2018 Oct 1. pii: S0301-5629(18)30335-1. doi: 10.1016/j.ultrasmedbio.2018.08.002.

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    2019-04-11 huangdf
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    2019-05-18 sunylz
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    2018-12-02 zgwhgch
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target=_blank style='color:#2F92EE;'>#ultrasound#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=18124, encryptionId=a8941812471, topicName=ultrasound)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2cc329519145, createdName=linlin2322, createdTime=Sat Feb 16 21:10:00 CST 2019, time=2019-02-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1657082, encodeId=8c33165e08287, content=<a href='/topic/show?id=3ca31e71903' target=_blank style='color:#2F92EE;'>#TRA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=15, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17719, encryptionId=3ca31e71903, topicName=TRA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=757b24868428, createdName=bsmagic9140, createdTime=Thu Apr 25 07:10:00 CST 2019, time=2019-04-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1349366, encodeId=fbb31349366a1, content=<a href='/topic/show?id=838593e35b2' target=_blank style='color:#2F92EE;'>#辐射#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=16, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=93735, encryptionId=838593e35b2, topicName=辐射)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8e4c53, createdName=jiyangfei, createdTime=Mon Oct 08 10:10:00 CST 2018, time=2018-10-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1419274, encodeId=5e2e14192e4ee, content=<a href='/topic/show?id=2e2e10182602' target=_blank style='color:#2F92EE;'>#骨缺损#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101826, encryptionId=2e2e10182602, topicName=骨缺损)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=51173492599, createdName=lfcmxl, createdTime=Mon Oct 08 10:10:00 CST 2018, time=2018-10-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1609157, encodeId=78a9160915e17, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Mon Oct 08 10:10:00 CST 2018, time=2018-10-08, status=1, ipAttribution=)]
    2019-09-02 siiner
  5. 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  6. 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target=_blank style='color:#2F92EE;'>#ultrasound#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=18124, encryptionId=a8941812471, topicName=ultrasound)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2cc329519145, createdName=linlin2322, createdTime=Sat Feb 16 21:10:00 CST 2019, time=2019-02-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1657082, encodeId=8c33165e08287, content=<a href='/topic/show?id=3ca31e71903' target=_blank style='color:#2F92EE;'>#TRA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=15, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17719, encryptionId=3ca31e71903, topicName=TRA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=757b24868428, createdName=bsmagic9140, createdTime=Thu Apr 25 07:10:00 CST 2019, time=2019-04-25, status=1, 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  7. 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createdBy=51173492599, createdName=lfcmxl, createdTime=Mon Oct 08 10:10:00 CST 2018, time=2018-10-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1609157, encodeId=78a9160915e17, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Mon Oct 08 10:10:00 CST 2018, time=2018-10-08, status=1, ipAttribution=)]
    2019-04-25 bsmagic9140
  8. [GetPortalCommentsPageByObjectIdResponse(id=1913763, encodeId=8b821913e6310, content=<a href='/topic/show?id=6f5328e398' target=_blank style='color:#2F92EE;'>#ASO#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2873, encryptionId=6f5328e398, topicName=ASO)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e2e0330, createdName=huangdf, createdTime=Thu Apr 11 07:10:00 CST 2019, time=2019-04-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1918309, encodeId=8479191830913, content=<a href='/topic/show?id=4f26341994' target=_blank style='color:#2F92EE;'>#Bio#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3419, encryptionId=4f26341994, topicName=Bio)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12de429, 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target=_blank style='color:#2F92EE;'>#ultrasound#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=18124, encryptionId=a8941812471, topicName=ultrasound)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2cc329519145, createdName=linlin2322, createdTime=Sat Feb 16 21:10:00 CST 2019, time=2019-02-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1657082, encodeId=8c33165e08287, content=<a href='/topic/show?id=3ca31e71903' target=_blank style='color:#2F92EE;'>#TRA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=15, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17719, encryptionId=3ca31e71903, topicName=TRA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=757b24868428, createdName=bsmagic9140, createdTime=Thu Apr 25 07:10:00 CST 2019, time=2019-04-25, status=1, 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createdBy=51173492599, createdName=lfcmxl, createdTime=Mon Oct 08 10:10:00 CST 2018, time=2018-10-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1609157, encodeId=78a9160915e17, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Mon Oct 08 10:10:00 CST 2018, time=2018-10-08, status=1, ipAttribution=)]
    2018-10-08 jiyangfei
  9. 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target=_blank style='color:#2F92EE;'>#ultrasound#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=18124, encryptionId=a8941812471, topicName=ultrasound)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2cc329519145, createdName=linlin2322, createdTime=Sat Feb 16 21:10:00 CST 2019, time=2019-02-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1657082, encodeId=8c33165e08287, content=<a href='/topic/show?id=3ca31e71903' target=_blank style='color:#2F92EE;'>#TRA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=15, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17719, encryptionId=3ca31e71903, topicName=TRA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=757b24868428, createdName=bsmagic9140, createdTime=Thu Apr 25 07:10:00 CST 2019, time=2019-04-25, status=1, 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createdBy=51173492599, createdName=lfcmxl, createdTime=Mon Oct 08 10:10:00 CST 2018, time=2018-10-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1609157, encodeId=78a9160915e17, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Mon Oct 08 10:10:00 CST 2018, time=2018-10-08, status=1, ipAttribution=)]
    2018-10-08 lfcmxl
  10. 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