J Periodontol: 原发性干燥综合征和类风湿性关节炎患者的牙周状况

2018-05-29 MedSci MedSci原创

本研究的目的是比较原发性干燥综合征(pSS)和类风湿性关节炎(RA)受试者中的临床牙周参数以及龈沟液(GCF)和血浆中肿瘤坏死因子-α(TNF-α),白细胞介素-1β(IL-1β),干扰素γ(干扰素-γ)和胱天蛋白酶-1的表达。

本研究的目的是比较原发性干燥综合征(pSS)和类风湿性关节炎(RA)受试者中的临床牙周参数以及龈沟液(GCF)和血浆中肿瘤坏死因子-α(TNF-α),白细胞介素-1β(IL-1β),干扰素γ(干扰素-γ)和胱天蛋白酶-1的表达。

实验纳入了44名pSS受试者,39名RA患者和30名全身健康的受试者,收集受试者的血浆和GCF样本,记录受试者的菌斑指数(PI),探诊出血(BOP)和探诊深度(PD)。通过酶联免疫吸附测定法测定血浆和GCF中 TNF-α,IL-1β,IFN-γ和胱天蛋白酶-1的水平。

结果:在所有研究组中,GCF和血浆中IFN-γ和TNF-α的水平没有差异(p> 0.05)。pSS组GCF中的 IL-1β水平高于健康组(p = 0.035)。pSS组 Caspase-1 GCF水平显着高于RA组(p = 0.032)。与RA和健康组相比,pSS中血浆IL-1β水平最高(p <0.001)。健康组Caspase-1血浆水平高于pSS和RA组(p <0.001)。

pSS患者的牙周状况与全身健康者无差异。但是,结果仍需要进一步的研究验证。

原始出处:

Ozcaka O, et al. Clinical periodontal status and inflammatory cytokines in primary sjogren syndrome and rheumatoid artritis. Journal of Periodontology. 2018 May. doi:10.1002/JPER.17-0730

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topicName=null, topicId=null, topicList=[TopicDto(id=37056, encryptionId=06413e05695, topicName=原发性干燥综合征)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2aa512204505, createdName=dinorsor528, createdTime=Thu May 31 11:56:00 CST 2018, time=2018-05-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=319793, encodeId=09de319e93cb, content=学习一下谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLGSUSR8zwnWWLT4FMl5XH8S58HuZslVkLsAPbXDXaliagK7TOxQfmngKibG1yrDonepCLDkcxGk8hS/0, createdBy=b8282062892, createdName=changjiu, createdTime=Tue May 29 23:54:27 CST 2018, time=2018-05-29, status=1, ipAttribution=)]
    2018-05-31 lmm397
  5. 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topicName=null, topicId=null, topicList=[TopicDto(id=37056, encryptionId=06413e05695, topicName=原发性干燥综合征)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2aa512204505, createdName=dinorsor528, createdTime=Thu May 31 11:56:00 CST 2018, time=2018-05-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=319793, encodeId=09de319e93cb, content=学习一下谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLGSUSR8zwnWWLT4FMl5XH8S58HuZslVkLsAPbXDXaliagK7TOxQfmngKibG1yrDonepCLDkcxGk8hS/0, createdBy=b8282062892, createdName=changjiu, createdTime=Tue May 29 23:54:27 CST 2018, time=2018-05-29, status=1, ipAttribution=)]
    2018-05-31 zhouqu_8
  7. 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    2018-05-29 changjiu

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