JACC:心肌纤维化是Chagas心肌病不良预后的独立预测因素

2018-11-22 MedSci MedSci原创

心脏磁共振(CMR)在Chagas心肌病患者中常常可见心肌纤维化(MF),且可能会不良预后相关。本研究的目的旨在评估MF在预测Chagas心肌病患者不良预后中的价值。本研究纳入了130名Chagas心肌病患者(平均年龄53.6 ± 11.5岁,女性占53.9%),绝大部分患者无明显心衰和心律失常表现,但心超或心电图常常会有异常。主要终点事件是全因死亡率、心脏移植和流产性心源性猝死的复合事件,次要终

心脏磁共振(CMR)在Chagas心肌病患者中常常可见心肌纤维化(MF),且可能会不良预后相关。本研究的目的旨在评估MF在预测Chagas心肌病患者不良预后中的价值。

本研究纳入了130名Chagas心肌病患者(平均年龄53.6 ± 11.5岁,女性占53.9%),绝大部分患者无明显心衰和心律失常表现,但心超或心电图常常会有异常。主要终点事件是全因死亡率、心脏移植和流产性心源性猝死的复合事件,次要终点事件是全因死亡率。分析结果发现,CMR显示的左室扩张或功能不全较常见,有76.1%的患者存在MF,平均质量大小为 15.2 ± 16.5g。经过平均5.05年时间的随访,58例(44.6%)患者出现复合事件,45例(34.6%)患者出现死亡。MF与主要终点事件的发生呈相关性(HR:1.031; 95% CI: 1.013 - 1.049; p = 0.001),且独立于Rassi 风险评分。另外,MF与患者的全因死亡率也呈独立相关性(HR:1.028; 95% CI: 1.005 - 1.051; p = 0.017)。

研究结果显示,在Chagas心肌病患者中,心肌纤维化是不良预后的独立预测因素。

原始出处:

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    2019-02-21 许安
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    2019-10-17 vera_1203
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    2019-02-22 hbwxf
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    2019-01-23 okhuali
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JACC:NT-proBNP指导下的心衰治疗花费更多且无益处

GUIDE-IT临床试验比较了N-末端B型利钠肽(NT-proBNP)指导下的心衰治疗和单纯的内科治疗在高风险心衰患者中的效果,但该研究因无明显作用而被提前终止。本研究的目的旨在评估GUIDE-IT临床试验中的治疗相关生活质量(QOL)和经济产出。本研究对GUIDE-IT临床试验患者中的基线、随机分组后3、6、12和24个月的QOL。在对446名随机分至NT-proBNP指导下心衰治疗组患者和44

JACC:心脏磁共振疤痕可预测慢性Chagas 心肌病患者的预后

慢性Chagas 心肌病(CCC)患者有很明显的心肌纤维化,引起心脏猝死风险大大增加。本研究的目的旨在评估心脏磁共振晚期钆增强(LGE)的疤痕存在是否预示着CCC患者的不良预后。本研究纳入了140名CCC患者(女性占52.1%,平均年龄57岁),并对其进行了心脏磁共振和LGE检查,主要终点事件是心源性死亡和室性心动过速的复合事件,次要终点事件是心源性死亡、持续性室性心动过速或心源性住院的复合事件。

JAHA:2型糖尿病患者肥胖与不良预后的相关性研究

近期研究显示糖尿病患者可能存在肥胖悖论现象。本研究的目的旨在评估2型糖尿病患者的不良预后事件与肥胖的关系。本研究纳入了ACCORD 临床研究中的有10年2型糖尿病史的患者。主要终点事件是全因死亡率,次要终点事件是心源性死亡、非致死性心梗和卒中。分析结果显示,三级肥胖患者(BMI≥40)的全因死亡率最高,二级肥胖其次,超重患者的风险最小。患者的BMI与腰围存在相关性(r=0.802),BMI与主要和

JAHA:地高辛通过影响血小板激活水平影响房颤患者预后

地高辛的使用与房颤患者不良心血管事件的发生相关,本研究提出假设,地高辛可以通过血小板的激活影响心血管风险。本研究是房颤抗凝患者前瞻性研究的事后分析,将患者分成地高辛使用组(n=132)和非地高辛使用组(n=388),并对其测定了血小板活化标志物血栓烷B2(TxB2)的尿排泄量和血清地高辛浓度(SDC)。本研究也同时进行了体外实验,将对照和房颤患者的血小板体外培养,并用标准剂量的地高辛进行孵育(0.