NEJM:3天阿莫西林治疗方案用于儿童吸入性肺炎

2020-07-02 MedSci原创 MedSci原创

在马拉维胸部吸入性肺炎儿童中,3天阿莫西林治疗方案的疗效与5天方案相当

在资源匮乏的非洲,最佳的儿童肺炎抗生素治疗时间研究尚不充分。近日研究人员在马拉维利隆圭地区进行了一项双盲、随机、对照、非劣效性试验,比较阿莫西林3天或5天治疗方案对小儿吸入性肺炎的疗效差异(咳嗽持续时间<14天或呼吸困难,伴随着明显的胸壁内陷)。
 
无人类免疫缺陷病毒(HIV)感染儿童参与研究,年龄在2至59个月,并患有胸部肺炎,随机接受阿莫西林治疗,每天两次,为期3天或5天,随访14天。主要结果是第6天治疗失败,二次分析包括在第14天评估治疗失败或复发。
 
3000名儿童参与研究,其中1497名儿童被分配到3天组,1503名儿童被分配到5天组。研究第6天,3天组的治疗失败率为5.9%,5天组的治疗失败率为5.2%(校正后的差异为0.7%),满足非劣效性标准。治疗第14天,3天组12.5%和5天组10.8%的患儿在第6天之前出现治疗失败或第14天复发(组间差异为1.7%)。两组发生严重不良事件的儿童比例相似(3天组为9.8%,5天组为8.8%)。
 
研究认为,在马拉维胸部吸入性肺炎儿童中,3天阿莫西林治疗方案的疗效与5天方案相当。
 
原始出处:
 
Amy-Sarah Ginsburg et al. Amoxicillin for 3 or 5 Days for Chest-Indrawing Pneumonia in Malawian Children. N Engl J Med, July 02, 2020.

 

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    2020-07-02 旺医

    顶刊就是顶刊,谢谢梅斯带来这么高水平的研究报道,我们科里同事经常看梅斯,分享梅斯上的信息

    0

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    2020-07-02 mswert122

    #阿莫西林#老药新花🦋🦋

    0

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