IBD:粪便气味可以区分小儿肠易激综合征与炎症性肠病

2018-10-21 MedSci MedSci原创

小儿肠易激综合征(IBS)和功能性腹痛的诊断检查通常需要用于区分炎症性肠病(IBD)的侵入性测试,这会给患者带来很大的负担,因此需要开发用于IBS和IBD的非侵入性诊断生物标志物。一些研究表明IBS / FAP中的微生物群改变被认为是可以有粪便挥发性有机化合物(VOC)反映出来。本研究的目的是评估是否可以通过粪便VOC将儿童IBS与IBD和健康对照区分开来。

背景
小儿肠易激综合征(IBS)和功能性腹痛的诊断检查通常需要用于区分炎症性肠病(IBD)的侵入性测试,这会给患者带来很大的负担,因此需要开发用于IBS和IBD的非侵入性诊断生物标志物。一些研究表明IBS / FAP中的微生物群改变被认为是可以有粪便挥发性有机化合物(VOC)反映出来。本研究的目的是评估是否可以通过粪便VOC将儿童IBS与IBD和健康对照区分开来。

方法
根据ROME IV标准诊断研究人员筛选了IBS患者,以及在4至17岁的新发IBD患者和健康对照(HC)患者。通过不对称离子迁移率光谱法分析粪便VOC的差异。

结果
研究人员分析了15名IBS 患儿,30名IBD(15名溃疡性结肠炎,15名克罗恩病)患者和30名HC的粪便VOCs。研究结果发现使用VOC检测将IBS 和IBD区分是可行的,且具有较高准确度([AUC],0.94; 95%[CI],0.88-1;P<0.00001)。

结论
本项研究结果表明小儿IBS 与IBD可通过粪便VOC分析进行区分,且具有高准确度。

原始出处:

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    2018-10-23 bnurmamat
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    2018-10-23 Homburg
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