BMC: Gastroenterology:肝移植术后肥胖与血管并发症的关系

2019-03-08 不详 MedSci原创

目前接受肝移植(LT)的肥胖患者数量不断增加,因此研究肥胖对移植后结局的影响非常重要。肝移植患者血管并发症很少见,但是其是LT后发病率和死亡率的严重原因。目前尚不清楚移植前肥胖是否与LT后血管并发症发生率增加有关。因此,本项研究旨在探明二者之间的关系。

背景
目前接受肝移植(LT)的肥胖患者数量不断增加,因此研究肥胖对移植后结局的影响非常重要。肝移植患者血管并发症很少见,但是其是LT后发病率和死亡率的严重原因。目前尚不清楚移植前肥胖是否与LT后血管并发症发生率增加有关。因此,本项研究旨在探明二者之间的关系。

方法
研究人员收集了2007年至今所有的文献,主要观察结果是肥胖对成人LT受者的血管并发症发生率的影响。还分析了存活率和胆道并发症发生率。计算风险比(RR)和95%置信区间(CI)以比较体重指数(BMI)≥30kg / m 2和<30 kg / m 2的组之间的差异。

结果
总共有6项回顾性队列研究本纳入分析,共纳入987名BMI≥30kg / m 2的患者(高BMI组)和2911名BMI <3 0 kg / m 2的患者(对照组)。所有研究的纽卡斯尔 - 渥太华量表评分≥4。高BMI组和对照组的血管并发症发生率相似(RR = 1.13,95%CI:0.87-1.47,P= 0.27),患者存活率,移植物存活率和胆道并发症发生率也相似。在亚组分析中,BMI≥35与BMI <25kg/m 2之间的血管并发症发生率无差异。当存在酒精性肝病时,那些具有BMI≥30kg /m2有血管并发症比具有BMI <30Kg/m2的发病率较高(RR = 1.55,95%CI:1.07-2.25 ,P= 0.02)。

结论
BMI不影响LT后血管并发症的发生率。高移植前BMI不是LT后患者存活和胆道并发症的危险因素。

原始出处:

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    2020-01-27 许安
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    2019-11-10 cy0324
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    2019-10-17 丁鹏鹏
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