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Am J Cancer Res：circ-ABCB10通过海绵miR-1271促进乳腺癌的进展

2017-10-04 MedSci MedSci原创

circ-ABCB10miR-1271乳腺癌
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循环RNA（circRNA RNA）是人类癌症发生及发展的关键调节因子，但其在乳腺癌肿瘤发生中的作用尚不清楚。本研究旨在研究circRNA对乳腺癌致癌作用的表达谱及其潜在的调控机制。使用人circRNA微阵列筛选乳腺癌组织中异常表达的circRNA。结果发现circBBB10在乳腺癌组织中明显上调。且扩大样本量进行筛查结果亦是如此。体外功能丧失实验显示，敲除circ-ABCB10可抑制乳腺癌细胞的

循环RNA（circRNA RNA）是人类癌症发生及发展的关键调节因子，但其在乳腺癌肿瘤发生中的作用尚不清楚。本研究旨在研究circRNA对乳腺癌致癌作用的表达谱及其潜在的调控机制。

使用人circRNA微阵列筛选乳腺癌组织中异常表达的circRNA。结果发现circBBB10在乳腺癌组织中明显上调。且扩大样本量进行筛查结果亦是如此。体外功能丧失实验显示，敲除circ-ABCB10可抑制乳腺癌细胞的增殖，并促进细胞的凋亡。生物信息学预测程序预测了在circ-ABCB10和miR-1271中的互补序列，并通过荧光素酶报告基因测定验证。最后，研究发现miR-1271在乳腺癌细胞中可逆转circ-ABCB10的功能，证实了circ-ABCB10对miR-1271的海绵效应。

总体而言，该研究结果确定了乳腺癌肿瘤发生中的新的功能circ-ABCB10，并揭示了通过海绵miR-1271的circBBB10的重要调控作用，为探究乳腺癌的发病机理提供了新的见解。

原始出处：

Hai-Feng Liang, Xing-Zeng Zhang, et al., Circular RNA circ-ABCB10 promotes breast cancer proliferation and progression through sponging miR-1271. Am J Cancer Res. 2017; 7(7): 1566–1576. Published online 2017 Jul 1.

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    2018-01-19 smallant2002

    #miR#

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    2017-11-08 cmj21wellington

    #ABC#

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    2017-10-12 大爰

    好视频学习了谢谢分享!

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content=循环RNA(circRNARNA)是人类癌症发生及发展的关键调节因子.但其在乳腺癌肿瘤发生中的作用尚不清楚.本研究旨在研究circRNA对乳腺癌致癌作用的表达谱及其潜在的调控机制., beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7cJ6ejWUr2nIia8qOvAKNdLHr32Df6G8iaoaOx6pHaoiacwp26DaslxZHCGbibZhhCGven4rvmWP60GahtzgFjgCjR/0, createdBy=6b111703011, createdName=有备才能无患, createdTime=Wed Oct 04 21:11:40 CST 2017, time=2017-10-04, status=1, ipAttribution=)]
    2017-10-07 卡圣

    学习了.感谢分享

    0

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    2017-10-06 明月清辉

    谢谢分享.学习了

    0

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    2017-10-05 方舒

    学习

    0

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level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Thu Oct 05 17:05:16 CST 2017, time=2017-10-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=250499, encodeId=c74c25049996, content=学习了新知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201006/4db877c2887649beb09cb5effd0b38c7/916f66edd48a4e77b20ebc3e14b6e45c.jpg, createdBy=141e1980133, createdName=Y—xianghai, createdTime=Thu Oct 05 09:17:59 CST 2017, time=2017-10-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=250373, encodeId=ad252503e3f6, content=循环RNA(circRNARNA)是人类癌症发生及发展的关键调节因子.但其在乳腺癌肿瘤发生中的作用尚不清楚.本研究旨在研究circRNA对乳腺癌致癌作用的表达谱及其潜在的调控机制., beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7cJ6ejWUr2nIia8qOvAKNdLHr32Df6G8iaoaOx6pHaoiacwp26DaslxZHCGbibZhhCGven4rvmWP60GahtzgFjgCjR/0, createdBy=6b111703011, createdName=有备才能无患, createdTime=Wed Oct 04 21:11:40 CST 2017, time=2017-10-04, status=1, ipAttribution=)]
    2017-10-05 明天会更好！

    谢谢分享.学习了!

    0

  8. 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level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Thu Oct 05 17:05:16 CST 2017, time=2017-10-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=250499, encodeId=c74c25049996, content=学习了新知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201006/4db877c2887649beb09cb5effd0b38c7/916f66edd48a4e77b20ebc3e14b6e45c.jpg, createdBy=141e1980133, createdName=Y—xianghai, createdTime=Thu Oct 05 09:17:59 CST 2017, time=2017-10-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=250373, encodeId=ad252503e3f6, 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    2017-10-05 虈亣靌

    不错的.学习了.谢谢分享!

    0

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content=循环RNA(circRNARNA)是人类癌症发生及发展的关键调节因子.但其在乳腺癌肿瘤发生中的作用尚不清楚.本研究旨在研究circRNA对乳腺癌致癌作用的表达谱及其潜在的调控机制., beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7cJ6ejWUr2nIia8qOvAKNdLHr32Df6G8iaoaOx6pHaoiacwp26DaslxZHCGbibZhhCGven4rvmWP60GahtzgFjgCjR/0, createdBy=6b111703011, createdName=有备才能无患, createdTime=Wed Oct 04 21:11:40 CST 2017, time=2017-10-04, status=1, ipAttribution=)]
    2017-10-05 Y—xianghai

    学习了新知识

    0

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content=循环RNA(circRNARNA)是人类癌症发生及发展的关键调节因子.但其在乳腺癌肿瘤发生中的作用尚不清楚.本研究旨在研究circRNA对乳腺癌致癌作用的表达谱及其潜在的调控机制., beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7cJ6ejWUr2nIia8qOvAKNdLHr32Df6G8iaoaOx6pHaoiacwp26DaslxZHCGbibZhhCGven4rvmWP60GahtzgFjgCjR/0, createdBy=6b111703011, createdName=有备才能无患, createdTime=Wed Oct 04 21:11:40 CST 2017, time=2017-10-04, status=1, ipAttribution=)]
    2017-10-04 有备才能无患

    循环RNA(circRNARNA)是人类癌症发生及发展的关键调节因子.但其在乳腺癌肿瘤发生中的作用尚不清楚.本研究旨在研究circRNA对乳腺癌致癌作用的表达谱及其潜在的调控机制.

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