Gen Dent:适度使用!漱口水可抗菌,但是也不可忽视滥用的毒性

2018-04-09 MedSci MedSci原创

本研究评估了5种不同市售漱口水(Cepacol Traditional,Colgate Plax Fresh Mint,Listerine Cool Mint,Oral-B Complete和Sensodyne)对白色念珠菌、金黄色葡萄球菌、粪肠球菌、变异链球菌、大肠杆菌和铜绿假单胞菌的作用效果。此外,研究人员还分析了漱口水对牙龈成纤维细胞的细胞毒性作用。使用3-(4,5-二甲基噻唑-2-基)-2

本研究评估了5种不同市售漱口水(Cepacol Traditional,Colgate Plax Fresh Mint,Listerine Cool Mint,Oral-B Complete和Sensodyne)对白色念珠菌、金黄色葡萄球菌、粪肠球菌、变异链球菌、大肠杆菌和铜绿假单胞菌的作用效果。此外,研究人员还分析了漱口水对牙龈成纤维细胞的细胞毒性作用。

使用3-(4,5-二甲基噻唑-2-基)-2,5-二苯基四唑溴化物(MTT)的比色测定来研究48小时后的生物膜的情况,以及24小时后的牙龈成纤维细胞的活性。将生物膜暴露于漱口水2个不同的时间长度:T1,制造商推荐的时间(30或60秒);和T2,建议时间的两倍(60或120秒)。在两种暴露时间(T1和T2)下,所有防腐剂漱口剂均可明显减少生物膜(P <0.05),并且存活的牙龈成纤维细胞也明显减少(P <0.05)。

综上所述,该研究结果表明,商业漱口水可有效抗菌膜,且其对细菌比对白色念珠菌更有效。此外,研究人员还观察到漱口水对牙龈成纤维细胞具有明显的细胞毒性作用。

原始出处:

de Oliveira JR, Belato KK, et al., Mouthwashes: an in vitro study of their action on microbial biofilms and cytotoxicity to gingival fibroblasts. Gen Dent. 2018 Mar-Apr;66(2):28-34.

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    2018-06-01 zchen
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