DIABETOLOGIA：生长分化因子15与糖尿病发病率呈正相关

2019-04-04 不详网络

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生长分化因子15 (GDF-15)是一种factor-β超家族的抗炎细胞因子。GDF-15的循环水平与肥胖或糖尿病患者的高血糖有关，但目前尚缺乏关于GDF-15水平与糖尿病风险之间关系的纵向证据。我们的目的是探讨循环水平的GDF-15基线水平是否与未来城市中年人群的糖尿病发病率呈正相关。

在1991年至1994年期间，对马尔默饮食和癌症-心血管队列4360名无糖尿病(平均年龄57.4±5.96岁，男性38.6%)的参与者的空腹空腹血浆GDF-15水平进行了测量。随访19.0±5.16年(均值±SD)后，采用Cox比例危险回归分析研究基线GDF-15与糖尿病发病的关系，并对已建立的混杂因素进行调整。敏感性分析包括进一步校正c反应蛋白(CRP)水平。

结果显示，在随访期间，621人患糖尿病。糖尿病发病率的多变量校正HR为1.43 (95% CI 1.11, 1.83;p为趋势值= 0.007)，与GDF-15的前四分位数相比，为1.17 (95% CI 1.07, 1.28;每SD增加GDF-15, p < 0.001)。如果参与者按照空腹血糖基线进行分组，GDF-15与糖尿病风险之间的关系只在空腹血糖未受损的组中明显(n = 3973)。随着年龄的增长，这种相关性往往不那么显著:对于年龄≤55岁、56-60岁(>55和≤60岁)和>60岁的糖尿病患者，GDF-15每SD增加一个多变量调整的HRs分别为1.24 (95% CI 1.08, 1.42)、1.19 (95% CI 1.00, 1.41)和1.04 (95% CI 0.89, 1.23)。校正CRP水平后，GDF-15的单位SD HR值增加显著(1.21,95% CI 1.09, 1.35) (p = 0.015)，但第4组与第1 / 4组相比HR值无显著差异(HR 1.30;95% CI 1.01, 1.67;p代表趋势= 0.061)。

研究表明，GDF-15可能有助于识别有突发糖尿病风险的人群，特别是那些≤60岁的人群。

原始出处：

Xue Bao, Yan Borné, Growth differentiation factor 15 is positively associated with incidence of diabetes mellitus: the Malmö Diet and Cancer–Cardiovascular Cohort

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2019-10-08 lifestar

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2019-06-20 ms5439512287675881

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2019-09-27 医者仁心

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2019-04-26 qingrejiedu

#生长分化因子15#

46 0
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2019-04-05 misszhang

谢谢MedSci提供最新的资讯

44 0
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2019-04-04 orangesking

好

59 0

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