Crit Care Med:血管加压剂的使用增加了创伤性失血性休克患者的死亡风险

2018-09-11 xing.T MedSci原创

由此可见,在控制偏倚(创伤严重程度、液体复苏量)后,创伤性失血性休克患者使用血管加压剂治疗与死亡率相关。

近日,危重病医学领域权威杂志Critical Care Medicine上发表了一篇研究文章,研究人员旨在评估创伤性失血性休克患者血管加压剂使用与死亡率之间的可能关联。

该研究为回顾性队列研究,是在2004年至2015年期间日本260家急救医院的创伤性失血性休克患者中完成的,3551名创伤性失血性休克患者在到达急诊室时出现收缩性低血压(<90mmHg),并在最初24小时内接受输血。这些患者在最初的24小时内使用血管加压剂治疗创伤性失血性休克。

在236698名创伤患者中,3551名患者被纳入研究。总体而言,血管加压剂治疗组的459名患者中有198名(43%)患者死亡,而为采用血管加压剂治疗组的3092名患者中有481名(16%)患者死亡。调整年龄、性别、发病年份、受伤原因、受伤机制、急诊科的生命体征、伤害严重程度评分以及最初24小时内使用院前静脉输液和输血量后,血管加压剂的使用对住院死亡率的比值比为2.172(95%CI为1.666-2.833)。在倾向评分匹配队列和两个亚组分析(大量输血和存活损伤模型)中,血管加压剂的使用与较高的死亡率相关(比值比为2.168; 95%CI为1.442-3.320),(大量输血模型比值比为2.029; 95%CI为1.414-2.911;存活损伤模型比值比为1.959; 95%CI为1.364-2.814)。

由此可见,在控制偏倚(创伤严重程度、液体复苏量)后,创伤性失血性休克患者使用血管加压剂治疗与死亡率相关。

原始出处:

Aoki, Makoto,et al. Use of Vasopressor Increases the Risk of Mortality in TraumaticHemorrhagic Shock: A Nationwide Cohort Study in Japan.critical care medicine.https://journals.lww.com/ccmjournal/Abstract/onlinefirst/Use_of_Vasopressor_Increases_the_Risk_of_Mortality.96155.aspx

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    2018-11-29 yyj062
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time=2018-09-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1609108, encodeId=c1e7160910819, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Thu Sep 13 02:19:00 CST 2018, time=2018-09-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=344517, encodeId=459634451e53, content=谢谢分享,学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6Nx0VGA4QMDzOP8oAgnV4h51EjSfehJ9QxyiaSmw8PB56BhY8KXFSxHCibXrzcy4abrzSibXQPxJ9kzrLcJyhhB8a/0, createdBy=1d3b1672603, createdName=明月清辉, createdTime=Tue Sep 11 12:37:33 CST 2018, time=2018-09-11, status=1, ipAttribution=)]
    2019-08-27 amyloid
  5. 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time=2018-09-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1609108, encodeId=c1e7160910819, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Thu Sep 13 02:19:00 CST 2018, time=2018-09-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=344517, encodeId=459634451e53, content=谢谢分享,学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6Nx0VGA4QMDzOP8oAgnV4h51EjSfehJ9QxyiaSmw8PB56BhY8KXFSxHCibXrzcy4abrzSibXQPxJ9kzrLcJyhhB8a/0, createdBy=1d3b1672603, createdName=明月清辉, createdTime=Tue Sep 11 12:37:33 CST 2018, time=2018-09-11, status=1, ipAttribution=)]
  6. [GetPortalCommentsPageByObjectIdResponse(id=1994177, encodeId=a3c619941e770, content=<a href='/topic/show?id=0fcb4431056' target=_blank style='color:#2F92EE;'>#失血性休克#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=44310, encryptionId=0fcb4431056, topicName=失血性休克)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=68b666, createdName=zhangying8788, createdTime=Wed Oct 03 13:19:00 CST 2018, time=2018-10-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2085326, encodeId=d2dc2085326c5, content=<a href='/topic/show?id=a3ff443092f' target=_blank style='color:#2F92EE;'>#失血性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=44309, encryptionId=a3ff443092f, topicName=失血性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=052a130, 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href='/topic/show?id=e7cc32022c7' target=_blank style='color:#2F92EE;'>#创伤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=32022, encryptionId=e7cc32022c7, topicName=创伤)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=aa5a2500103, createdName=ms920641618706883, createdTime=Thu Sep 13 02:19:00 CST 2018, time=2018-09-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1522666, encodeId=49db15226669c, content=<a href='/topic/show?id=4c364430828' target=_blank style='color:#2F92EE;'>#失血#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=44308, encryptionId=4c364430828, topicName=失血)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d6c011466504, createdName=daviiliu, createdTime=Thu Sep 13 02:19:00 CST 2018, time=2018-09-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1609108, encodeId=c1e7160910819, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Thu Sep 13 02:19:00 CST 2018, time=2018-09-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=344517, encodeId=459634451e53, content=谢谢分享,学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6Nx0VGA4QMDzOP8oAgnV4h51EjSfehJ9QxyiaSmw8PB56BhY8KXFSxHCibXrzcy4abrzSibXQPxJ9kzrLcJyhhB8a/0, createdBy=1d3b1672603, createdName=明月清辉, createdTime=Tue Sep 11 12:37:33 CST 2018, time=2018-09-11, status=1, ipAttribution=)]
  7. 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href='/topic/show?id=e7cc32022c7' target=_blank style='color:#2F92EE;'>#创伤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=32022, encryptionId=e7cc32022c7, topicName=创伤)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=aa5a2500103, createdName=ms920641618706883, createdTime=Thu Sep 13 02:19:00 CST 2018, time=2018-09-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1522666, encodeId=49db15226669c, content=<a href='/topic/show?id=4c364430828' target=_blank style='color:#2F92EE;'>#失血#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=44308, encryptionId=4c364430828, topicName=失血)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d6c011466504, createdName=daviiliu, createdTime=Thu Sep 13 02:19:00 CST 2018, time=2018-09-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1609108, encodeId=c1e7160910819, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Thu Sep 13 02:19:00 CST 2018, time=2018-09-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=344517, encodeId=459634451e53, content=谢谢分享,学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6Nx0VGA4QMDzOP8oAgnV4h51EjSfehJ9QxyiaSmw8PB56BhY8KXFSxHCibXrzcy4abrzSibXQPxJ9kzrLcJyhhB8a/0, createdBy=1d3b1672603, createdName=明月清辉, createdTime=Tue Sep 11 12:37:33 CST 2018, time=2018-09-11, status=1, ipAttribution=)]
    2018-09-13 daviiliu
  8. 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  9. 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time=2018-09-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1609108, encodeId=c1e7160910819, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Thu Sep 13 02:19:00 CST 2018, time=2018-09-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=344517, encodeId=459634451e53, content=谢谢分享,学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6Nx0VGA4QMDzOP8oAgnV4h51EjSfehJ9QxyiaSmw8PB56BhY8KXFSxHCibXrzcy4abrzSibXQPxJ9kzrLcJyhhB8a/0, createdBy=1d3b1672603, createdName=明月清辉, createdTime=Tue Sep 11 12:37:33 CST 2018, time=2018-09-11, status=1, ipAttribution=)]
    2018-09-11 明月清辉

    谢谢分享,学习了

    0