JAHA:高血压患者β阻断剂的使用与左心房功能受损有关!

2017-02-13 xing.T MedSci原创

β阻断剂的使用与高血压左心房功能受损显著相关。在最近的试验证明这种相关性可能是使用β受体阻滞剂增加心房颤动和脑卒中风险的基础。

高血压患者存在左心房机械功能受损,其可能会导致各种并发症,包括房性心律失常、脑卒中和心脏衰竭。不同种类的降压药物对中心血流动力学和左心室功能有着不同的影响。然而,它们左心房功能的影响是鲜为人知的。近日,心血管疾病领域权威杂志JAHA上针对这一问题发表了一篇研究文章。

研究人员分析了212例无心脏衰竭和心房颤动的高血压患者。研究人员采用特征-追踪算法的稳定态自由旋进造影测量了参与者的左心房应变。在调整了年龄、性别、种族、体重指数、血压、糖尿病、左心房体积、左心室肥厚、左心室射血分数的多变量模型中,β受体阻滞剂的使用与较低的整体纵向应变(标准化β= -0.21;P=0.008)和较低的左心房扩张指数(标准化β=-0.30;P<0.001)相关,提示左心房储备功能受损。β阻滞剂的使用也与较低的正性应变(标准化β=-0.19;P=0.012)和舒张早期应变率(标准化β=0.15;P=0.039)相关,表明左心房管道功能受损。最后,β阻滞剂的使用也与较低的舒张晚期应变(标准化β=0.15;P=0.049)、应变率(标准化β=0.18;P=0.019)和较低的左心房主动排空分数(标准化β=0.27;P<0.001),说明助推器泵功能受损。而使用其他抗高血压药物则与左心房功能无关。

由此可见,β阻断剂的使用与高血压左心房功能受损显著相关。在最近的试验证明这种相关性可能是使用β受体阻滞剂增加心房颤动和脑卒中风险的基础。

原始出处:


Mayank Sardana,et al. Beta‐Blocker Use Is Associated With Impaired Left Atrial Function in Hypertension. JAHA.2017. https://doi.org/10.1161/JAHA.116.005163

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    2017-06-29 ylz8411
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    2017-02-15 zhaohui6731
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    2017-02-15 sodoo

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