J Rheumatol:系统性红斑狼疮女性患者的孕前心血管健康和妊娠结局

2018-07-19 xiangting MedSci原创

差/中等的孕前心血管健康影响SLE女性患者早产和SGA婴儿的妊娠结局。

这项研究旨在评估由美国心脏协会(AHA)指南测量的孕前心血管(CV)健康对系统性红斑狼疮(SLE)女性患者妊娠结局的影响。

该研究纳入霍普金斯狼疮妊娠队列中的患者。根据AHA定义,使用孕前最近一次门诊就诊或妊娠早期的体重指数(BMI)、总胆固醇和血压(BP)来确定CV健康状况(理想、中等或差)。结局包括早产、出生时的胎龄和小于胎龄(SGA)。使用广义估计方程的多因素线性和logistic回归模型估计每个CV健康因子和结局的关联。

分析包括309名活产儿。其中有95名早产儿(31%),在293名有出生体重的婴儿中,18%为SGA。理想BMI、总胆固醇和血压分别占妊娠的56%、85%和51%。调整种族和使用泼尼松后,中等BMI与SGA的几率降低相关(OR 0.26,95%CI 0.11-0.63)。总胆固醇中等/差与早产几率升高相关(OR 2.21,95%CI 1.06-4.62)。BP中等/差与出生时胎龄减少相关(β-0.96,95%CI -1.62至-0.29)。

差/中等的孕前心血管健康影响SLE女性患者早产和SGA婴儿的妊娠结局。孕前努力维持BMI、总胆固醇和血压在推荐的理想范围内对于改善SLE女性的妊娠结局非常重要。

原始出处:

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    2018-11-30 szhvet
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    2018-07-21 zhouqu_8
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    2018-07-19 183****7028

    学习

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系统性红斑狼疮(SLE)是一种全身性的自身免疫性疾病,以多系统受累和产生多种自身抗体为主要特征,临床表现千变万化,不同患者的表现往往有很大差异。与症状体征一样,患者之间的疾病严重度也不尽相同,有些患者病情相对较轻,不危及生命,有些患者内脏受损,病情进展迅速并危及生命。当累及中枢神经系统,出现神经精神症状时, 则称为神经精神性狼疮(NPSLE),又名狼疮性脑病。NPSLE作为SLE 最常见且最严重的

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根据现有最佳证据,使用糖皮质激素与SLE患者的ON密切相关。

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系统性红斑狼疮(systemic lupuserythematosus,SLE)是一种累及多系统、多脏器,临床表现复杂多样,病程迁延反复的自身免疫病。SLE患者血清中可存在各种自身抗体,对疾病的发生发展、临床诊断与治疗、病程转归与预后均发挥着至关重要的作用。