INFLAMM BOWEL DIS:粪便钙卫蛋白检测在无症状炎症性肠病患者中的临床应用现状

2017-06-10 许奕晗 MedSci原创

在无症状的炎症性肠病(IBD)患者中,一般通过反复地进行各种检查以期望尽早识别疾病是否发生了恶化。其中反映肠道炎症状况的粪钙卫蛋白(FC)可以有效预测IBD复发的的情况。

在无症状的炎症性肠病IBD)患者中,一般通过反复地进行各种检查以期望尽早识别疾病是否发生了恶化。其中反映肠道炎症状况的粪钙卫蛋白(FC)可以有效预测IBD复发的的情况。

一篇近期发表在INFLAME BOWEL DIS 上的一篇荟萃分析探讨了粪钙卫蛋白在预测IBD复发中的效能。此篇荟萃分析共检索了1719篇文章,最终入选了6篇。入选标准为:文献必须是前瞻性研究且患者入组条件必须为疾病缓解期,至少有连续两次测量粪钙卫蛋白,检测时间间隔为2周至6个月内。

作者发现,IBD无症状患者的粪钙卫蛋白测量值连续2次大于临界值,则此类患者在未来2至3个月内疾病复发的概率为53%至83%。而粪钙卫蛋白测量值连续2次均在临界值以下的患者未来2至3个月内有67%至94%的可能继续处于缓解状态。最后,作者建议,连续2次粪钙卫蛋白水平的异常与疾病近期复发高度相关,应该给予患者更为积极的治疗。

原始出处:


Heida Anke,et al.Clinical Utility of Fecal Calprotectin Monitoring in Asymptomatic Patients with Inflammatory Bowel Disease: A Systematic Review and Practical Guide.INFLAMM BOWEL DIS.2017.

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    2017-11-24 智智灵药
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    2017-12-27 yuandd
  4. 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createdTime=Mon Jun 12 06:18:00 CST 2017, time=2017-06-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1599962, encodeId=5417159996273, content=<a href='/topic/show?id=508e6e03203' target=_blank style='color:#2F92EE;'>#炎症性肠病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67032, encryptionId=508e6e03203, topicName=炎症性肠病患者)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a9fa18776644, createdName=huangshifeng, createdTime=Mon Jun 12 06:18:00 CST 2017, time=2017-06-12, status=1, ipAttribution=)]
  5. [GetPortalCommentsPageByObjectIdResponse(id=2057594, encodeId=67e1205e59495, content=<a href='/topic/show?id=c02b106e29a' target=_blank style='color:#2F92EE;'>#LAM#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10672, encryptionId=c02b106e29a, topicName=LAM)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=智智灵药, createdTime=Fri Nov 24 18:18:00 CST 2017, time=2017-11-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1835683, encodeId=b8c31835683fc, content=<a href='/topic/show?id=cfdc22e893f' target=_blank style='color:#2F92EE;'>#临床应用#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=22789, encryptionId=cfdc22e893f, topicName=临床应用)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fc8528, 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createdTime=Mon Jun 12 06:18:00 CST 2017, time=2017-06-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1599962, encodeId=5417159996273, content=<a href='/topic/show?id=508e6e03203' target=_blank style='color:#2F92EE;'>#炎症性肠病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67032, encryptionId=508e6e03203, topicName=炎症性肠病患者)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a9fa18776644, createdName=huangshifeng, createdTime=Mon Jun 12 06:18:00 CST 2017, time=2017-06-12, status=1, ipAttribution=)]
    2017-06-12 xiaoyeshuang
  6. 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createdTime=Mon Jun 12 06:18:00 CST 2017, time=2017-06-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1599962, encodeId=5417159996273, content=<a href='/topic/show?id=508e6e03203' target=_blank style='color:#2F92EE;'>#炎症性肠病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67032, encryptionId=508e6e03203, topicName=炎症性肠病患者)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a9fa18776644, createdName=huangshifeng, createdTime=Mon Jun 12 06:18:00 CST 2017, time=2017-06-12, status=1, ipAttribution=)]
    2017-06-12 Homburg
  7. 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