Lancet:绝经期激素治疗(MHT)会导致更大的乳腺癌风险

2019-09-01 不详 MedSci原创

发表在"The Lancet"杂志上的最新研究数据表明,绝经期激素治疗(MHT)可导致持续十年以上的乳腺癌风险增加。共同作者瓦莱丽·贝拉尔(Valerie Beral)指出:"MHT使用会导致风险加倍,因为激素停止使用后存在持续风险。"

发表在"The Lancet"杂志上的最新研究数据表明,绝经期激素治疗(MHT)可导致持续十年以上的乳腺癌风险增加。共同作者瓦莱丽·贝拉尔(Valerie Beral)指出:"MHT使用会导致风险加倍,因为激素停止使用后存在持续风险。"

在该研究中,108647名平均65岁患有乳腺癌的绝经后妇女,其中55575名患者使用过MHT。

进一步的分析显示,除了阴道雌激素之外,每种MHT类型都与较高的乳腺癌风险有关,这种风险随着使用时间的增加而"稳定增加"。具体而言, 50至69岁未服用MHT患乳腺癌女性的绝对风险为6.3%,雌激素加上每日孕激素5年的患者为8.3%。同样,使用雌激素加间歇性孕激素治疗5年的为7.7%,而仅使用雌激素治疗的风险为6.8%。

共同作者吉莉安·里夫斯表示:"我们不想让女性感到惊恐,但我们希望她们选择开始或继续MRT的治疗,不要做出错误的决定。"

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    2020-06-23 hxzhang
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    2020-03-03 howi
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    2019-10-22 sjq027
  5. [GetPortalCommentsPageByObjectIdResponse(id=1770320, encodeId=04e51e70320b1, content=<a href='/topic/show?id=df9c23e868a' target=_blank style='color:#2F92EE;'>#乳腺癌风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23786, encryptionId=df9c23e868a, topicName=乳腺癌风险)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4a9538161180, createdName=gaoxiaoe, createdTime=Mon Sep 30 10:04:00 CST 2019, time=2019-09-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2042074, encodeId=9fb920420e420, content=<a href='/topic/show?id=01ff116e8c5' target=_blank style='color:#2F92EE;'>#MHT#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11678, encryptionId=01ff116e8c5, topicName=MHT)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4f9e287, createdName=hxzhang, createdTime=Tue Jun 23 20:04:00 CST 2020, time=2020-06-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1830227, encodeId=6327183022ee5, content=<a href='/topic/show?id=1b6210686b2' target=_blank style='color:#2F92EE;'>#Lancet#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10686, encryptionId=1b6210686b2, topicName=Lancet)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3f0227, createdName=howi, createdTime=Tue Mar 03 02:04:00 CST 2020, time=2020-03-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2061873, encodeId=d14220618e341, content=<a href='/topic/show?id=e6e1e15509f' target=_blank style='color:#2F92EE;'>#癌风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71550, encryptionId=e6e1e15509f, topicName=癌风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d58a435, createdName=sjq027, createdTime=Tue Oct 22 16:04:00 CST 2019, time=2019-10-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1257219, encodeId=c34b125e219e5, content=<a href='/topic/show?id=cdfce8879b1' target=_blank style='color:#2F92EE;'>#绝经#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=78879, encryptionId=cdfce8879b1, topicName=绝经)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=yeye5224612, createdTime=Tue Sep 03 12:04:00 CST 2019, time=2019-09-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1304844, encodeId=588a130484422, content=<a href='/topic/show?id=9b09e89052f' target=_blank style='color:#2F92EE;'>#绝经期#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=78905, encryptionId=9b09e89052f, topicName=绝经期)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3289320, createdName=海豹, createdTime=Tue Sep 03 12:04:00 CST 2019, time=2019-09-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1307421, encodeId=a6e5130e42127, content=<a href='/topic/show?id=b1d766836e4' target=_blank style='color:#2F92EE;'>#激素治疗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=66836, encryptionId=b1d766836e4, topicName=激素治疗)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=bfa6343, createdName=aliceclz, createdTime=Tue Sep 03 12:04:00 CST 2019, time=2019-09-03, status=1, ipAttribution=)]
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    2019-09-03 海豹
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Lancet发表III期ECLIPSE研究,证明IL-23单抗TREMFYA比IL-17单抗COSENTYX治疗中度至重度银屑病具有更好的长期疗效

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