J Dent Res:牙周炎与慢性阻塞性肺病的相关性

2019-03-23 不详 网络

尽管已知牙周炎与慢性阻塞性肺病(COPD)之间存在相似的病理生理过程,但二者之间的关系尚未完全了解。本研究旨在检验在考虑吸烟时牙周炎与COPD发展风险增加相关的假设。基于5-y随访人群的队列研究的分析基于900名社区居住的日本成年人(年龄:68.8±6.3 [平均值±SD],46.0%男性),无COPD,年龄60岁或以上,至少缺失1颗牙齿。根据基线牙周炎严重程度(无/轻度,中度和重度)将参与者分为

尽管已知牙周炎与慢性阻塞性肺病(COPD)之间存在相似的病理生理过程,但二者之间的关系尚未完全了解。本研究旨在检验在考虑吸烟时牙周炎与COPD发展风险增加相关的假设。

基于5-y随访人群的队列研究的分析基于900名社区居住的日本成年人(年龄:68.8±6.3 [平均值±SD],46.0%男性),无COPD,年龄60岁或以上,至少缺失1颗牙齿。根据基线牙周炎严重程度(无/轻度,中度和重度)将参与者分为3类。COPD是通过1秒内用力呼气量(FEV1)/用力肺活量(FVC)的固定比率<0.7和FEV1 / FVC低于正常下限的固定比例确定。泊松回归用于根据牙周炎的严重程度计算COPD的相对风险(RR)。还计算了人口归因分数(PAF)。

结果,在随访期间,22名(2.4%)受试者患有COPD。与无/轻度牙周炎患者相比,重度牙周炎患者发生COPD的风险明显增加(RR = 3.55; 95%置信区间[CI],1.18至10.67),但无/轻度和中度之间没有明显差异(RR = 1.48; 95%CI,0.56至3.90)。校正潜在的混杂因素后,包括吸烟强度,严重牙周炎与COPD风险之间的关系仍然显著(RR = 3.51; 95%CI,1.15至10.74)。同样,牙周炎严重程度与COPD风险呈正相关(趋势P = 0.043)。由牙周炎引起的COPD PAF为22.6%。

总之,这些数据突出了牙周炎作为COPD危险因素的潜在重要性。

原始出处:

Takeuchi K, Matsumoto K, et al., Periodontitis Is Associated with Chronic Obstructive Pulmonary Disease. J Dent Res. 2019 Mar 8:22034519833630. doi: 10.1177/0022034519833630.

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    2019-12-18 tomyang96
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    2019-08-24 amy0559
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