J Periodontol:透明质酸对种植体周围炎龈下微生物组的短期影响

2019-10-14 不详 网络

本研究旨在评估透明质酸凝胶在第45天对至少植入一年的种植体周围炎植入物的微生物组的影响。在种植体周围炎患者中进行了一项随机对照试验。在基线和治疗45天后均收集了包含样本的拭子。使用16S rRNA测序技术研究透明质酸凝胶对龈下微生物组的影响。在基线和随访45天后对54例患者的108个样本进行了分析。在基线时,样品中获得了三个具有不同微生物组成的层,代表了与种植体周围炎相关的三个主要微生物群落。透明

本研究旨在评估透明质酸凝胶在第45天对至少植入一年的种植体周围炎植入物的微生物组的影响。

在种植体周围炎患者中进行了一项随机对照试验。在基线和治疗45天后均收集了包含样本的拭子。使用16S rRNA测序技术研究透明质酸凝胶对龈下微生物组的影响。

在基线和随访45天后对54例患者的108个样本进行了分析。在基线时,样品中获得了三个具有不同微生物组成的层,代表了与种植体周围炎相关的三个主要微生物群落。透明质酸治疗后,第1层的任何变量均未显示任何差异,而在第2层中,链球菌,Veillonella,Rothia和Granulicatella的相对丰都降低了(p <0.05)。同样,透明质酸治疗后,第3层的Prevotella和弯曲杆菌(p <0.05)减少。与对照组相比,透明质酸处理后第3层的微生物多样性降低(p <0.05),而对照组却有所增加(p <0.05)。

总之,该研究结果表明,透明质酸减少了与种植体周围炎相关的微生物(尤其是早期定植细菌)的相对丰度,表明在疾病发展的最初阶段有特定作用。透明质酸不会改变非口腔属的相对丰度。在植入物周围炎的晚期使用透明质酸会导致微生物α多样性降低,提示植入物周围部位对细菌定植具有保护作用。

原始出处:

Soriano-Lerma A, Magán-Fernández A, et al., Short-term effects of hyaluronic acid on the subgingival microbiome in peri-implantitis. A randomized controlled clinical trial. J Periodontol. 2019 Oct 2. doi: 10.1002/JPER.19-0184. 

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    2020-01-20 huangdf
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    2019-11-25 feather89
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