脱发有救了!JAK抑制剂巴瑞替尼可恢复80%头发生长,可能是斑秃的良药!

2021-10-03 网络 网络

今日,礼来(Eli Lilly and Company)和Incyte公司公布了JAK抑制剂巴瑞替尼(baricitinib,英文商品名Olumiant),在治疗斑秃患者的两项关键性3期临床试验中获得

今日,礼来(Eli Lilly and Company)和Incyte公司公布了JAK抑制剂巴瑞替尼(baricitinib,英文商品名Olumiant),在治疗斑秃患者的两项关键性3期临床试验中获得的详细结果。试验结果显示,每日口服一次巴瑞替尼(剂量为4 mg),最早在16周时就可以显著改善严重斑秃患者的头皮毛发再生。新闻稿指出,该公司计划在今年下半年向美国FDA递交监管申请,巴瑞替尼有潜力成为首款FDA批准的斑秃疗法。

Baricitinib(巴瑞克替尼)是经欧盟批准的首款治疗类风湿性关节炎的JAK抑制剂,由美国医药巨头礼来(Eli Lilly)与Incyte公司合作研发。巴瑞替尼是一款口服JAK抑制剂,它已经获得FDA批准用于治疗类风湿性关节炎。在2020年,它获得FDA的突破性疗法认定,用于治疗斑秃(见:礼来的JAK抑制剂Baricitinib治疗斑秃,获得FDA授予突破性疗法称号)。此前,礼来已经宣布,它在两项3期临床试验BRAVE-AA1和BRAVE-AA2中达到主要终点,在治疗36周后显著改善严重斑秃患者的头皮毛发再生。

斑秃(AA)是全球发病率第二高的脱发类型,全球范围内大约有 1.47 亿 AA 患者,中国大约有 400 万。其中约一半的 AA 患者可以一年内自愈,但缓解后又复发的患者容易进展为中重度斑秃,甚至普秃,治疗难度更大。目前为止并没有治疗斑秃的通用疗法,FDA 也没有批准任何治疗 AA 的药物。

研究发现,斑秃患者的毛囊细胞中因遗传或外界刺激等原因而高表达 NKG2D 蛋白,使得 CD4、CD8 T 细胞、NK 细胞等对毛囊进行攻击,毛囊分泌的 IL-15 通过与 JAK1 和 JAK3 结合而激活 T 细胞,从而导致 IFN-γ分泌上调,与毛囊细胞上 IFN-γ受体结合后能激活更多 IL-15 分泌,形成持续刺激的回路,T 细胞也在不断增殖。目前,JAK 抑制剂已成为治疗 AA 的热门候选药物之一。

 

图片

▲此前一名严重斑秃患者在治疗前和接受巴瑞替尼治疗8个月后的表现(图片来源:参考资料[2])

最新公布的数据分析显示,在BRAVE-AA1临床试验中,接受剂量为4 mg的巴瑞替尼治疗的患者最早在16周时头皮毛发再生获得统计显著改善。在第16周时,18.5%的患者达到头皮毛发覆盖面积80%以上的标准,安慰剂组这一数值为4.2%(p<0.001)。

在BRAVE-AA2临床试验中,接受剂量为4 mg的巴瑞替尼治疗的患者最早在24周时头皮毛发再生获得统计显著改善。28.2%患者头皮毛发覆盖率超过80%,对照组这一数值为1.3%(p<0.001)这些患者在接受治疗之前平均头皮毛发覆盖率只有14.5%,他们中很多人已经患病十多年。 

图片

 

此外,数据分析显示,接受治疗剂量为4 mg的巴瑞替尼治疗36周后,患者的眉毛和睫毛的再生也获得显著改善,两项临床试验中大约三分之一的患者眉毛和睫毛没有明显缺失,对照组这一数值在3.1~5.6%之间。

安全性方面,巴瑞替尼的安全性特征与此前发表的安全性数据一致,没有发现新的安全性信号。小于2.6%的患者因为不良事件停止接受治疗。大多数治疗相关不良事件为轻度或重度。最常见的不良事件为上呼吸道感染、头痛、粉刺、尿道感染和与肌肉相关的血液标志物升高。见:关节炎药物JAK抑制剂Baricitinib治疗斑秃:患者获得显著改善

“这些发现对于严重斑秃患者来说是好消息,它们支持巴瑞替尼帮助患者再生头发、眉毛和睫毛的潜力。”这些分析的主要作者,耶鲁大学医学院的皮肤学教授Brett King博士说,“斑秃目前还没有获得批准的全身性疗法,存在显著未竟需求。患者和医生们渴望获得FDA批准的治疗选择。”

目前国内已有部分 JAK 抑制剂已被开发用于治疗 AA,如礼来的 JAK1/2 抑制剂巴瑞替尼、辉瑞的 JAK3 抑制剂 PF-06651600、泽璟医药的杰克替尼和瑞石生物的 SHR0302。

PF-06651600 是中国最早进入临床试验用于治疗 AA 的 JAK 抑制剂,适应症为:用于治疗≥12 岁中重度斑秃患者(包括全秃 [AT] 和普秃 [AU]),据药物临床试验登记与信息公示平台,辉瑞正在开展两项在 AA 受试者中评价 PF-06651600 疗效和安全性的 2b/3 期国际多中心临床试验。

恒瑞JAK抑制剂2期临床达到主要终点,见:恒瑞医药SHR0302片治疗斑秃II期临床达到主要研究终点

参考资料:

[1] OLUMIANT® Significantly Improved Hair Regrowth to At Least 80% Scalp Coverage as Early as 24 Weeks Across First Completed Phase 3 Studies for Alopecia Areata. Retrieved September 30, 2021, from https://investor.lilly.com/news-releases/news-release-details/olumiantr-significantly-improved-hair-regrowth-least-80-scalp

[2] Olamiju et al., (2019). Treatment of severe alopecia areata with baricitinib. JAAD case reports, DOI:https://doi.org/10.1016/j.jdcr.2019.07.005

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    2022-03-28 ms8000001440794224

    有点贵

    0

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GetPortalCommentsPageByObjectIdResponse(id=1057262, encodeId=a1bb105e262f2, content=斑秃患者的**, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210517/512da905d2d443f7a834bf7f1f65d2d1/ce6b4c4e8e77442fa8a22d303220db5a.jpg, createdBy=f1b85503152, createdName=ms6000000014307403, createdTime=Sun Oct 03 21:51:01 CST 2021, time=2021-10-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1057087, encodeId=d969105e08798, content=你去我里特利热度自己费县教育局, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTIrrxxDxnLic8t6EAs38Qfwo6H2h6JMleIgb9OSYf6LMnVDkQEqUXWoSDWboibjhOBI9SJDTXweqQIA/132, createdBy=50aa5321359, createdName=查查佳佳, createdTime=Sun Oct 03 11:34:43 CST 2021, time=2021-10-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1057070, encodeId=62c8105e07030, content=希望早日在国内上市, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=cec72111766, createdName=乙娆, createdTime=Sun Oct 03 10:13:48 CST 2021, time=2021-10-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1057048, encodeId=83e3105e0481a, content=<a href='/topic/show?id=00664830602' target=_blank style='color:#2F92EE;'>#巴瑞替尼#</a>可恢复80%头发生长,可能是<a href='/topic/show?id=015c5e95173' target=_blank style='color:#2F92EE;'>#斑秃#</a>的良药!, beContent=null, objectType=article, channel=null, level=null, likeNumber=125, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=48306, encryptionId=00664830602, topicName=巴瑞替尼), TopicDto(id=57951, encryptionId=015c5e95173, topicName=斑秃)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211210/ede9c51184aa4f54ae6c1164cfb8eeac/967dbf3eff2943c7bf3ccfec3a776ab0.JPG, createdBy=a33789389, createdName=病毒猎手, createdTime=Sun Oct 03 07:57:05 CST 2021, time=2021-10-03, status=1, ipAttribution=)]
    2022-03-23 jklm09
  4. [GetPortalCommentsPageByObjectIdResponse(id=1738058, encodeId=18611e38058b4, content=<a href='/topic/show?id=0abd10215e0' target=_blank style='color:#2F92EE;'>#JAK#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10215, encryptionId=0abd10215e0, topicName=JAK)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6e8634348903, createdName=肉我只吃一口, createdTime=Wed Dec 01 20:56:12 CST 2021, time=2021-12-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1206580, encodeId=8e9c1206580bb, content=有点贵, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=133a6575802, createdName=ms8000001440794224, createdTime=Mon Mar 28 10:53:18 CST 2022, time=2022-03-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1852766, encodeId=6a9b1852e6635, content=<a href='/topic/show?id=f0a254918f0' target=_blank style='color:#2F92EE;'>#抑制剂#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54918, encryptionId=f0a254918f0, topicName=抑制剂)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=44a360, createdName=jklm09, createdTime=Wed Mar 23 02:56:12 CST 2022, time=2022-03-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1061017, encodeId=3c37106101e8e, content=好, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=16f15154952, createdName=跌死娃娃, createdTime=Sat Oct 16 12:43:04 CST 2021, time=2021-10-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1468613, encodeId=d17f146861358, content=<a href='/topic/show?id=7f7f443337a' target=_blank style='color:#2F92EE;'>#头发#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=44333, encryptionId=7f7f443337a, topicName=头发)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f09e6924959, createdName=qindq, createdTime=Mon Oct 04 22:56:12 CST 2021, time=2021-10-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1057377, encodeId=5fe1105e3778a, content=斑秃患者有戏, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=830f2464103, createdName=Bureaukey, createdTime=Mon Oct 04 08:21:28 CST 2021, time=2021-10-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1057262, encodeId=a1bb105e262f2, content=斑秃患者的**, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210517/512da905d2d443f7a834bf7f1f65d2d1/ce6b4c4e8e77442fa8a22d303220db5a.jpg, createdBy=f1b85503152, createdName=ms6000000014307403, createdTime=Sun Oct 03 21:51:01 CST 2021, time=2021-10-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1057087, encodeId=d969105e08798, content=你去我里特利热度自己费县教育局, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTIrrxxDxnLic8t6EAs38Qfwo6H2h6JMleIgb9OSYf6LMnVDkQEqUXWoSDWboibjhOBI9SJDTXweqQIA/132, createdBy=50aa5321359, createdName=查查佳佳, createdTime=Sun Oct 03 11:34:43 CST 2021, time=2021-10-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1057070, encodeId=62c8105e07030, content=希望早日在国内上市, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=cec72111766, createdName=乙娆, createdTime=Sun Oct 03 10:13:48 CST 2021, time=2021-10-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1057048, encodeId=83e3105e0481a, content=<a href='/topic/show?id=00664830602' target=_blank style='color:#2F92EE;'>#巴瑞替尼#</a>可恢复80%头发生长,可能是<a href='/topic/show?id=015c5e95173' target=_blank style='color:#2F92EE;'>#斑秃#</a>的良药!, beContent=null, objectType=article, channel=null, level=null, likeNumber=125, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=48306, encryptionId=00664830602, topicName=巴瑞替尼), TopicDto(id=57951, encryptionId=015c5e95173, topicName=斑秃)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211210/ede9c51184aa4f54ae6c1164cfb8eeac/967dbf3eff2943c7bf3ccfec3a776ab0.JPG, createdBy=a33789389, createdName=病毒猎手, createdTime=Sun Oct 03 07:57:05 CST 2021, time=2021-10-03, status=1, ipAttribution=)]
    2021-10-16 跌死娃娃

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1738058, encodeId=18611e38058b4, content=<a href='/topic/show?id=0abd10215e0' target=_blank style='color:#2F92EE;'>#JAK#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10215, encryptionId=0abd10215e0, topicName=JAK)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6e8634348903, createdName=肉我只吃一口, createdTime=Wed Dec 01 20:56:12 CST 2021, time=2021-12-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1206580, encodeId=8e9c1206580bb, content=有点贵, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=133a6575802, createdName=ms8000001440794224, createdTime=Mon Mar 28 10:53:18 CST 2022, time=2022-03-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1852766, encodeId=6a9b1852e6635, content=<a href='/topic/show?id=f0a254918f0' target=_blank style='color:#2F92EE;'>#抑制剂#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54918, encryptionId=f0a254918f0, topicName=抑制剂)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=44a360, createdName=jklm09, createdTime=Wed Mar 23 02:56:12 CST 2022, time=2022-03-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1061017, encodeId=3c37106101e8e, content=好, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=16f15154952, createdName=跌死娃娃, createdTime=Sat Oct 16 12:43:04 CST 2021, time=2021-10-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1468613, encodeId=d17f146861358, content=<a href='/topic/show?id=7f7f443337a' target=_blank style='color:#2F92EE;'>#头发#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=44333, encryptionId=7f7f443337a, topicName=头发)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f09e6924959, createdName=qindq, createdTime=Mon Oct 04 22:56:12 CST 2021, time=2021-10-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1057377, encodeId=5fe1105e3778a, content=斑秃患者有戏, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=830f2464103, createdName=Bureaukey, createdTime=Mon Oct 04 08:21:28 CST 2021, time=2021-10-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1057262, encodeId=a1bb105e262f2, content=斑秃患者的**, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210517/512da905d2d443f7a834bf7f1f65d2d1/ce6b4c4e8e77442fa8a22d303220db5a.jpg, createdBy=f1b85503152, createdName=ms6000000014307403, createdTime=Sun Oct 03 21:51:01 CST 2021, time=2021-10-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1057087, encodeId=d969105e08798, content=你去我里特利热度自己费县教育局, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTIrrxxDxnLic8t6EAs38Qfwo6H2h6JMleIgb9OSYf6LMnVDkQEqUXWoSDWboibjhOBI9SJDTXweqQIA/132, createdBy=50aa5321359, createdName=查查佳佳, createdTime=Sun Oct 03 11:34:43 CST 2021, time=2021-10-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1057070, encodeId=62c8105e07030, content=希望早日在国内上市, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=cec72111766, createdName=乙娆, createdTime=Sun Oct 03 10:13:48 CST 2021, time=2021-10-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1057048, encodeId=83e3105e0481a, content=<a href='/topic/show?id=00664830602' target=_blank style='color:#2F92EE;'>#巴瑞替尼#</a>可恢复80%头发生长,可能是<a href='/topic/show?id=015c5e95173' target=_blank style='color:#2F92EE;'>#斑秃#</a>的良药!, beContent=null, objectType=article, channel=null, level=null, likeNumber=125, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=48306, encryptionId=00664830602, topicName=巴瑞替尼), TopicDto(id=57951, encryptionId=015c5e95173, topicName=斑秃)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211210/ede9c51184aa4f54ae6c1164cfb8eeac/967dbf3eff2943c7bf3ccfec3a776ab0.JPG, createdBy=a33789389, createdName=病毒猎手, createdTime=Sun Oct 03 07:57:05 CST 2021, time=2021-10-03, status=1, ipAttribution=)]
    2021-10-04 qindq
  6. [GetPortalCommentsPageByObjectIdResponse(id=1738058, encodeId=18611e38058b4, content=<a href='/topic/show?id=0abd10215e0' target=_blank style='color:#2F92EE;'>#JAK#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10215, encryptionId=0abd10215e0, topicName=JAK)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6e8634348903, createdName=肉我只吃一口, createdTime=Wed Dec 01 20:56:12 CST 2021, time=2021-12-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1206580, encodeId=8e9c1206580bb, content=有点贵, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=133a6575802, createdName=ms8000001440794224, createdTime=Mon Mar 28 10:53:18 CST 2022, time=2022-03-28, status=1, ipAttribution=), 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GetPortalCommentsPageByObjectIdResponse(id=1468613, encodeId=d17f146861358, content=<a href='/topic/show?id=7f7f443337a' target=_blank style='color:#2F92EE;'>#头发#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=44333, encryptionId=7f7f443337a, topicName=头发)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f09e6924959, createdName=qindq, createdTime=Mon Oct 04 22:56:12 CST 2021, time=2021-10-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1057377, encodeId=5fe1105e3778a, content=斑秃患者有戏, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=830f2464103, createdName=Bureaukey, createdTime=Mon Oct 04 08:21:28 CST 2021, time=2021-10-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1057262, encodeId=a1bb105e262f2, content=斑秃患者的**, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210517/512da905d2d443f7a834bf7f1f65d2d1/ce6b4c4e8e77442fa8a22d303220db5a.jpg, createdBy=f1b85503152, createdName=ms6000000014307403, createdTime=Sun Oct 03 21:51:01 CST 2021, time=2021-10-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1057087, encodeId=d969105e08798, content=你去我里特利热度自己费县教育局, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTIrrxxDxnLic8t6EAs38Qfwo6H2h6JMleIgb9OSYf6LMnVDkQEqUXWoSDWboibjhOBI9SJDTXweqQIA/132, createdBy=50aa5321359, createdName=查查佳佳, createdTime=Sun Oct 03 11:34:43 CST 2021, time=2021-10-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1057070, encodeId=62c8105e07030, content=希望早日在国内上市, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=cec72111766, createdName=乙娆, createdTime=Sun Oct 03 10:13:48 CST 2021, time=2021-10-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1057048, encodeId=83e3105e0481a, content=<a href='/topic/show?id=00664830602' target=_blank style='color:#2F92EE;'>#巴瑞替尼#</a>可恢复80%头发生长,可能是<a href='/topic/show?id=015c5e95173' target=_blank style='color:#2F92EE;'>#斑秃#</a>的良药!, beContent=null, objectType=article, channel=null, level=null, likeNumber=125, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=48306, encryptionId=00664830602, topicName=巴瑞替尼), TopicDto(id=57951, encryptionId=015c5e95173, topicName=斑秃)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211210/ede9c51184aa4f54ae6c1164cfb8eeac/967dbf3eff2943c7bf3ccfec3a776ab0.JPG, createdBy=a33789389, createdName=病毒猎手, createdTime=Sun Oct 03 07:57:05 CST 2021, time=2021-10-03, status=1, ipAttribution=)]
    2021-10-04 Bureaukey

    斑秃患者有戏

    0

  7. 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encryptionId=015c5e95173, topicName=斑秃)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211210/ede9c51184aa4f54ae6c1164cfb8eeac/967dbf3eff2943c7bf3ccfec3a776ab0.JPG, createdBy=a33789389, createdName=病毒猎手, createdTime=Sun Oct 03 07:57:05 CST 2021, time=2021-10-03, status=1, ipAttribution=)]
    2021-10-03 ms6000000014307403

    斑秃患者的**

    0

  8. 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encryptionId=015c5e95173, topicName=斑秃)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211210/ede9c51184aa4f54ae6c1164cfb8eeac/967dbf3eff2943c7bf3ccfec3a776ab0.JPG, createdBy=a33789389, createdName=病毒猎手, createdTime=Sun Oct 03 07:57:05 CST 2021, time=2021-10-03, status=1, ipAttribution=)]
    2021-10-03 查查佳佳

    你去我里特利热度自己费县教育局

    0

  9. 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encryptionId=015c5e95173, topicName=斑秃)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211210/ede9c51184aa4f54ae6c1164cfb8eeac/967dbf3eff2943c7bf3ccfec3a776ab0.JPG, createdBy=a33789389, createdName=病毒猎手, createdTime=Sun Oct 03 07:57:05 CST 2021, time=2021-10-03, status=1, ipAttribution=)]
    2021-10-03 乙娆

    希望早日在国内上市

    0

  10. 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GetPortalCommentsPageByObjectIdResponse(id=1057262, encodeId=a1bb105e262f2, content=斑秃患者的**, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210517/512da905d2d443f7a834bf7f1f65d2d1/ce6b4c4e8e77442fa8a22d303220db5a.jpg, createdBy=f1b85503152, createdName=ms6000000014307403, createdTime=Sun Oct 03 21:51:01 CST 2021, time=2021-10-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1057087, encodeId=d969105e08798, content=你去我里特利热度自己费县教育局, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTIrrxxDxnLic8t6EAs38Qfwo6H2h6JMleIgb9OSYf6LMnVDkQEqUXWoSDWboibjhOBI9SJDTXweqQIA/132, createdBy=50aa5321359, createdName=查查佳佳, createdTime=Sun Oct 03 11:34:43 CST 2021, time=2021-10-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1057070, encodeId=62c8105e07030, content=希望早日在国内上市, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=cec72111766, createdName=乙娆, createdTime=Sun Oct 03 10:13:48 CST 2021, time=2021-10-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1057048, encodeId=83e3105e0481a, content=<a href='/topic/show?id=00664830602' target=_blank style='color:#2F92EE;'>#巴瑞替尼#</a>可恢复80%头发生长,可能是<a href='/topic/show?id=015c5e95173' target=_blank style='color:#2F92EE;'>#斑秃#</a>的良药!, beContent=null, objectType=article, channel=null, level=null, likeNumber=125, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=48306, encryptionId=00664830602, topicName=巴瑞替尼), TopicDto(id=57951, encryptionId=015c5e95173, topicName=斑秃)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211210/ede9c51184aa4f54ae6c1164cfb8eeac/967dbf3eff2943c7bf3ccfec3a776ab0.JPG, createdBy=a33789389, createdName=病毒猎手, createdTime=Sun Oct 03 07:57:05 CST 2021, time=2021-10-03, status=1, ipAttribution=)]
    2021-10-03 病毒猎手

    #巴瑞替尼#可恢复80%头发生长,可能是#斑秃#的良药!

    0

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