Oncolytics宣布溶瘤病毒Pelareorep与Keytruda联合治疗晚期胰腺癌的阳性1b期REO 024研究结果

2019-11-07 不详 MedSci原创

Oncolytics Biotech宣布其静脉内注射的溶瘤病毒pelareorep,与Merck公司的PD-1单抗Keytruda联合治疗晚期胰腺癌的阳性1b期REO 024研究结果。该研究共涉及11名患者,由西北大学Feinberg医学院的医学副教授Devalingam Mahalingam博士和西北大学的Robert H. Lurie综合癌症中心的成员完成。

Oncolytics Biotech宣布其静脉内注射的溶瘤病毒pelareorep,与Merck公司的PD-1单抗Keytruda联合治疗晚期胰腺癌的阳性1b期REO 024研究结果。该研究共涉及11名患者,由西北大学Feinberg医学院的医学副教授Devalingam Mahalingam博士和西北大学的Robert H. Lurie综合癌症中心的成员完成。

Mahalingam博士说:"Pelareorep和pembrolizumab联合化疗安全且耐受良好的,并显示出令人鼓舞的疗效。这项研究还强调了几种预处理和治疗中生物标记物在pelareorep治疗中的潜在效用,目前我们正在第二阶段临床研究中对其进行探索。"

1b期研究旨在评估在一线治疗不耐受或失败的转移性胰腺癌患者中,该治疗组合的安全性和耐受性。除了强大的安全性,该研究的积极发现还包括抗肿瘤活性、疾病的长期稳定和促进患者肿瘤发炎表型的客观反应。重要的是,这些结果支持将pelareorep和Keytruda的联合治疗方案推进到目前正在进行的2期临床开发中。

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    2020-12-13 胎胎

    期待溶瘤病毒的发展,这将为肿瘤免疫治疗带来新的希望!

    0

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    2019-11-09 zsyan
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    2020-05-06 feather89
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    2020-06-21 minlingfeng
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    2019-11-09 tidiq
  9. [GetPortalCommentsPageByObjectIdResponse(id=907529, encodeId=200990e529ad, content=期待溶瘤病毒的发展,这将为肿瘤免疫治疗带来新的希望!, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/SUJcTwXicljbKGJibCoQZE6Q4Qn5cogUOWth91eb3XIFk8sJ4IRn2a3W9WegJyEkwNMGcr1Hsxt9azlSQric4uPWg/132, createdBy=b9bd2355820, createdName=胎胎, createdTime=Sun Dec 13 09:56:15 CST 2020, time=2020-12-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1786946, encodeId=0b171e869464f, content=<a href='/topic/show?id=7b5d140207b' target=_blank style='color:#2F92EE;'>#Pelareorep#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14020, encryptionId=7b5d140207b, topicName=Pelareorep)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=dab8203, createdName=zsyan, createdTime=Sat Nov 09 00:14:00 CST 2019, time=2019-11-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1728187, encodeId=b9a51e28187f3, content=<a href='/topic/show?id=986913980dd' target=_blank style='color:#2F92EE;'>#PE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13980, encryptionId=986913980dd, topicName=PE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f06c33759375, createdName=feather89, createdTime=Wed May 06 06:14:00 CST 2020, time=2020-05-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1865735, encodeId=31cc1865e35ed, content=<a href='/topic/show?id=16ce133504e' target=_blank style='color:#2F92EE;'>#Oncol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13350, encryptionId=16ce133504e, topicName=Oncol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b63894, createdName=minlingfeng, createdTime=Sun Jun 21 07:14:00 CST 2020, time=2020-06-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1739527, encodeId=cccb1e3952752, content=<a href='/topic/show?id=8041e343504' target=_blank style='color:#2F92EE;'>#研究结果#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73435, encryptionId=8041e343504, topicName=研究结果)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=bbcd34536678, createdName=1249894fm84暂无昵称, createdTime=Thu Apr 16 21:14:00 CST 2020, time=2020-04-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1313772, encodeId=7e711313e727e, content=<a href='/topic/show?id=d4cc80e128f' target=_blank style='color:#2F92EE;'>#联合治疗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=80712, encryptionId=d4cc80e128f, topicName=联合治疗)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=263b421, createdName=zhaozuguo, createdTime=Sat Nov 09 01:14:00 CST 2019, time=2019-11-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1389573, encodeId=71a113895e33e, content=<a href='/topic/show?id=82a95988106' target=_blank style='color:#2F92EE;'>#晚期胰腺癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=59881, encryptionId=82a95988106, topicName=晚期胰腺癌)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdqq.qlogo.cn/qqapp/1103841572/2898B09F0DA89357D0D54A725E611AC7/100, createdBy=fdd32500040, createdName=ms7899726347904398, createdTime=Sat Nov 09 01:14:00 CST 2019, time=2019-11-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1625840, encodeId=2e711625840ca, content=<a href='/topic/show?id=bc29140196e' target=_blank style='color:#2F92EE;'>#PEL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14019, encryptionId=bc29140196e, topicName=PEL)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=399320916411, createdName=tidiq, createdTime=Sat Nov 09 01:14:00 CST 2019, time=2019-11-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1037935, encodeId=8285103e93574, content=谢谢梅斯分享这么多精彩信息, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=anti-cancer, createdTime=Thu Nov 07 13:14:00 CST 2019, time=2019-11-07, status=1, ipAttribution=)]
    2019-11-07 anti-cancer

    谢谢梅斯分享这么多精彩信息

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