SCI REP:房尘螨和蟑螂特异性免疫球蛋白E致敏与糖尿病发生有关!

2018-02-08 xing.T MedSci原创

由此可见,在一般人群中IgE致敏与DM之间存在强烈的正相关性,提示IgE可能是发生代谢性疾病的重要独立危险因素。

众所周知,免疫球蛋白E(IgE)可以激活肥大细胞。先前的研究已经表明肥大细胞可促进饮食诱导的肥胖和糖尿病(DM)发生。近日,Scientific reports杂志上发表了一篇研究文章,研究人员的目的是明确IgE致敏的成年人是否具有发生DM的风险。

研究人员对各地区各年龄段和性别组随机抽取的1528名成年人的血清总IgE和对屋尘螨、蟑螂和狗过敏原特异性IgE水平进行了检测。

研究人员发现受试者总的和三种过敏原特异性IgE水平与空腹血糖水平和胰岛素抵抗呈正相关。总体IgE水平升高(>100kU/L)的受试者与那些没有升高的受试者相比,调整各种协变量后发生糖尿病比值比为1.72(95%可信区间[95%CI]为1.17-2.54)。进一步控制之前的过敏性疾病并没有减弱总IgE水平与DM之间的相关性。对屋尘螨(比值比为1.63,95%CI为1.03-2.59)和蟑螂(比值比为2.27,95%CI为1.40-3.66)敏感的受试者发生DM的风险也增加。

由此可见,在一般人群中IgE致敏与DM之间存在强烈的正相关性,提示IgE可能是发生代谢性疾病的重要独立危险因素。

原始出处:

Mee Kyoung Kim,et al. House dust mite and Cockroach specific Immunoglobulin E sensitization is associated with diabetes mellitus in the adult Korean population.Scientific reports.2018. https://www.nature.com/articles/s41598-018-20573-0

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    2018-10-03 xzw113
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    2018-02-10 jyzxjiangqin

    特异性免疫球蛋白E.

    0

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    2018-02-09 changjiu

    学习一下谢谢

    0