BMC Gastroenterology:低维生素D水平与慢性乙型肝炎患者的高病毒载量相关

2019-06-26 不详 MedSci原创

以往的研究调查了慢性乙型肝炎病毒(HBV)感染患者的维生素D状况及其与HBV复制的关系,但结果不一致。本项荟萃分析旨在比较慢性乙型肝炎(CHB)患者和健康对照组之间的维生素D水平,并确定维生素D水平是否与HBV病毒载量相关。

背景
以往的研究调查了慢性乙型肝炎病毒(HBV)感染患者的维生素D状况及其与HBV复制的关系,但结果不一致。本项荟萃分析旨在比较慢性乙型肝炎(CHB)患者和健康对照组之间的维生素D水平,并确定维生素D水平是否与HBV病毒载量相关。

方法
研究人员通过PubMed,Web of Science,EMBASE和Cochrane数据库进行系统检索,以确定符合条件的研究,文献检索至2017年9月28日。并计算汇总平均差异(MD)和95%置信区间(CI),以定量估计维生素的差异CHB患者和对照之间的D水平。此外,血清维生素D水平与HBV病毒载量之间的相关性由汇总相关系数(r值)和相应的95%CI进行比较。

结果
研究人员共纳入7项研究,涉及814名CHB患者和696名健康对照。与健康对照相比,CHB患者的维生素D水平显着降低。纬度分层亚组分析表明,这种差异在低纬度地区更为明显。此外,研究人员观察到血清维生素D水平与HBV病毒载量之间呈负相关:r=-0.41;(95%CI:-0.54,-0.27)。

结论
CHB患者的维生素D水平低于健康对照,并且与HBV病毒载量呈负相关。

原始出处:

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topicName=Gastroenterol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0bed488, createdName=jktdtl, createdTime=Sun Mar 01 17:06:00 CST 2020, time=2020-03-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1807876, encodeId=5c48180e87685, content=<a href='/topic/show?id=dd7d8124144' target=_blank style='color:#2F92EE;'>#肝炎患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81241, encryptionId=dd7d8124144, topicName=肝炎患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=cd0d217, createdName=huiwelcome, createdTime=Sat Sep 14 13:06:00 CST 2019, time=2019-09-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1822313, encodeId=3b391822313f9, content=<a href='/topic/show?id=f4b110251e24' target=_blank style='color:#2F92EE;'>#高病毒载量#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102517, encryptionId=f4b110251e24, topicName=高病毒载量)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e93e105, createdName=anminleiryan, createdTime=Sat Mar 14 02:06:00 CST 2020, time=2020-03-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2072598, encodeId=a89920e25984d, content=<a href='/topic/show?id=9d4ee84647' target=_blank style='color:#2F92EE;'>#GAS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7846, encryptionId=9d4ee84647, topicName=GAS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e2dd327, createdName=许安, createdTime=Wed Jul 10 00:06:00 CST 2019, time=2019-07-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1825700, encodeId=92941825e004d, content=<a href='/topic/show?id=1a942339426' target=_blank 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GetPortalCommentsPageByObjectIdResponse(id=1271290, encodeId=c4fc12e129024, content=<a href='/topic/show?id=3d745346316' target=_blank style='color:#2F92EE;'>#慢性乙型肝炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=53463, encryptionId=3d745346316, topicName=慢性乙型肝炎)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/iaP1mV9qBwx5tE2F4xcG1r4x1PibWvluIFLB8VsViakqNMBia2Z0wFibVrYwDEILvHB1OomzzTAAGy5MVl5BrdEv9Bw/132, createdBy=e11f100, createdName=guguangxiang, createdTime=Fri Jun 28 05:06:00 CST 2019, time=2019-06-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1491151, encodeId=2666149115129, content=<a href='/topic/show?id=fb94e0991b3' target=_blank style='color:#2F92EE;'>#病毒载量#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=70991, encryptionId=fb94e0991b3, topicName=病毒载量)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1c1e8876950, createdName=grace5703, createdTime=Fri Jun 28 05:06:00 CST 2019, time=2019-06-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1504704, encodeId=f4251504e04b1, content=<a href='/topic/show?id=7730e85412' target=_blank style='color:#2F92EE;'>#Gastroenterology#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7854, encryptionId=7730e85412, topicName=Gastroenterology)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5fc29706655, createdName=chaojitidian, createdTime=Fri Jun 28 05:06:00 CST 2019, time=2019-06-28, status=1, ipAttribution=)]
  5. [GetPortalCommentsPageByObjectIdResponse(id=1974942, encodeId=858119e494204, content=<a href='/topic/show?id=f145355379' target=_blank style='color:#2F92EE;'>#BMC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3553, encryptionId=f145355379, topicName=BMC)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdqq.qlogo.cn/qqapp/101173734/363C99735735B7F4CB11D5F78F580525/100, createdBy=aab22500211, createdName=ms3025846204744509, createdTime=Mon Mar 09 22:06:00 CST 2020, time=2020-03-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2064748, encodeId=f3382064e4850, content=<a href='/topic/show?id=94ffe853a7' target=_blank style='color:#2F92EE;'>#Gastroenterol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7853, encryptionId=94ffe853a7, topicName=Gastroenterol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0bed488, createdName=jktdtl, createdTime=Sun Mar 01 17:06:00 CST 2020, time=2020-03-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1807876, encodeId=5c48180e87685, content=<a href='/topic/show?id=dd7d8124144' target=_blank style='color:#2F92EE;'>#肝炎患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81241, encryptionId=dd7d8124144, topicName=肝炎患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=cd0d217, createdName=huiwelcome, createdTime=Sat Sep 14 13:06:00 CST 2019, time=2019-09-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1822313, encodeId=3b391822313f9, content=<a href='/topic/show?id=f4b110251e24' target=_blank style='color:#2F92EE;'>#高病毒载量#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102517, encryptionId=f4b110251e24, topicName=高病毒载量)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e93e105, createdName=anminleiryan, createdTime=Sat Mar 14 02:06:00 CST 2020, time=2020-03-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2072598, encodeId=a89920e25984d, content=<a href='/topic/show?id=9d4ee84647' target=_blank style='color:#2F92EE;'>#GAS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7846, encryptionId=9d4ee84647, topicName=GAS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e2dd327, createdName=许安, createdTime=Wed Jul 10 00:06:00 CST 2019, time=2019-07-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1825700, encodeId=92941825e004d, content=<a href='/topic/show?id=1a942339426' target=_blank style='color:#2F92EE;'>#乙型肝炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=19, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23394, encryptionId=1a942339426, topicName=乙型肝炎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ea6321, createdName=okhuali, createdTime=Fri Jan 10 10:06:00 CST 2020, time=2020-01-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1711984, encodeId=85501e11984c5, content=<a href='/topic/show?id=9a1c289680' target=_blank style='color:#2F92EE;'>#AST#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2896, encryptionId=9a1c289680, topicName=AST)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8b9831894722, createdName=ms24272190615788285182, createdTime=Wed Jun 03 04:06:00 CST 2020, time=2020-06-03, status=1, ipAttribution=), 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topicList=[TopicDto(id=70991, encryptionId=fb94e0991b3, topicName=病毒载量)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1c1e8876950, createdName=grace5703, createdTime=Fri Jun 28 05:06:00 CST 2019, time=2019-06-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1504704, encodeId=f4251504e04b1, content=<a href='/topic/show?id=7730e85412' target=_blank style='color:#2F92EE;'>#Gastroenterology#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7854, encryptionId=7730e85412, topicName=Gastroenterology)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5fc29706655, createdName=chaojitidian, createdTime=Fri Jun 28 05:06:00 CST 2019, time=2019-06-28, status=1, ipAttribution=)]
    2019-07-10 许安
  6. 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  7. 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  8. 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环孢菌素(CSA)是自身免疫性肝炎(AIH)的替代治疗方法,然而,长期使用后其未知的安全性和疗效限制了其使用。本项研究的目的是评估使用CSA治疗AIH的儿童和年轻成人至少4年的长期结果。

Dig Dis Sci:丙型肝炎病毒进入巨噬细胞/单核细胞主要取决于巨噬细胞的吞噬作用

丙型肝炎病毒(HCV)是一种嗜肝性病原体病毒,肝细胞是HCV感染的靶细胞。越来越多的研究表明,一些非肝细胞也支持HCV进入和复制,比如巨噬细胞。目前,HCV进入巨噬细胞的机制尚不清楚。本研究旨在探究HCV进入巨噬细胞的机制。

BMC Gastroenterology: 抗病毒治疗可降低乙型肝炎相关性肝硬化患者的再出血率

乙肝患者都需要接受抗病毒治疗,目前尚未报道抗病毒治疗对降低乙型肝炎相关肝硬化患者内镜治疗再出血率的预防作用。因此,本项研究旨在探究二者的关系。

BMC Gastroenterology:丙型肝炎病毒感染状况与血糖水平的关系

丙型肝炎病毒(HCV)感染通常与葡萄糖代谢紊乱有关。然而,关于HCV的清除是否可以随后改变血清血糖和胰岛素抗性还没有定论。本研究的目的是评估HCV和抗病毒治疗对血糖水平和其他葡萄糖代谢参数的影响。

AP&T: 直接作用抗病毒治疗对丙型肝炎感染患者的肝外表现风险的影响

直接作用抗病毒(DAA)疗法可能在丙型肝炎病毒(HCV)感染的肝外表现中具有有益作用。但是,目前还没有研究证实,因此,本项研究的目的旨在评估DAA治疗对HCV几种肝外表现的风险的影响。

BMC Gastroenterology:埃塞俄比亚慢性乙型肝炎治疗患者死亡率的预测因素

撒哈拉以南非洲地区很难获得慢性乙型肝炎(CHB)的抗病毒治疗的机会; 因此,对非洲CHB患者开始治疗后的预后知之甚少。在这项研究中,研究人员旨在评估撒哈拉以南非洲最大的CHB队列这一的埃塞俄比亚的死亡率预测因子。