干细胞治疗早产儿支气管肺发育不良(BPD):具有治疗潜力

2021-05-06 Allan MedSci原创

支气管肺发育不良(BPD)是一种慢性肺疾病,发生在接受长期呼吸机和氧气治疗的早产儿中。尽管最近在新生儿重症监护医学领域取得了进步,但BPD仍然是导致早产儿死亡以及长期呼吸道和神经系统疾病的主要原因。

支气管肺发育不良(BPD)是一种慢性肺疾病,发生在接受长期呼吸机和氧气治疗的早产儿中。尽管最近在新生儿重症监护医学领域取得了进步,但BPD仍然是导致早产儿死亡以及长期呼吸道和神经系统疾病的主要原因。迫切需要新的治疗策略来改善这种严重的顽固性疾病的预后。

最近研究报告称,在具有免疫能力的新生动物中,异种间充质干细胞(MSCs)移植可减轻高氧性肺损伤,如肺泡化、氧化应激、炎症反应、细胞凋亡和纤维化受损。MSCs的这些保护作用取决于细胞类型,与成人脂肪组织或骨髓来源的MSCs相比,脐带血(UCB)来源的MSCs具有更好的保护作用。且早期移植比晚期移植显示出更好的保护作用,大剂量细胞移植显示更好的疗效。此外,在最近进行的I期临床试验中,人UCB来源的MSCs的气管内移植被证明是安全可行的。这些婴儿在长达2年的随访期间未发现与呼吸、生长或神经发育不良有关不良反应事件。在这里,研究人员报告了一项双盲、随机安慰剂对照的II期临床试验,评估了人类UCB来源的MSCs移植对早产儿的治疗效果。

这项II期双盲、随机、安慰剂对照临床试验是在出生后第5至14天之间接受机械呼吸机支持并伴呼吸恶化的妊娠23至28个孕周(GW)的早产儿中进行的。随机分配(1:1)接受干细胞(1×107细胞/ kg,n = 33)或安慰剂(n = 33)。结果显示,尽管MSC显著减少了气管抽吸液中的炎性细胞因子,但MSC移植并没有显著改善主要死亡或严重/中度BPD结果。在亚组分析中,在23至24 GW组患者中进行MSC移植后,严重BPD的次要结局从53%(8/15)显著降低至19%(3/16),而在25至28 GW亚组中则没有。总之,尽管MSC移植可能是安全可行的。

患者分组

 

原始出处:

https://stemcellsjournals.onlinelibrary.wiley.com/doi/full/10.1002/sctm.20-0330

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    2022-08-01 ms6000001585432287

    有没有全文翻译?

    0

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    2021-11-12 湘雅科教

    已拜读,受益匪浅。

    0

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  5. [GetPortalCommentsPageByObjectIdResponse(id=1236066, encodeId=f66112360666a, content=有没有全文翻译?, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=03dc8257132, createdName=ms6000001585432287, createdTime=Mon Aug 01 23:35:37 CST 2022, time=2022-08-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1892249, encodeId=f8201892249a5, content=<a href='/topic/show?id=1b445e1232d' target=_blank style='color:#2F92EE;'>#支气管#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=57123, encryptionId=1b445e1232d, topicName=支气管)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f503121, createdName=zjubiostat, createdTime=Fri Jul 09 20:43:50 CST 2021, time=2021-07-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1069543, encodeId=546310695436a, content=已拜读,受益匪浅。, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6c905475903, createdName=湘雅科教, createdTime=Fri Nov 12 10:38:21 CST 2021, time=2021-11-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1808726, encodeId=db691808e262e, content=<a href='/topic/show?id=098d820866b' target=_blank style='color:#2F92EE;'>#肺发育不良#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82086, encryptionId=098d820866b, topicName=肺发育不良)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=9fe6351, createdName=flyingeagle77, createdTime=Sat Dec 18 19:43:50 CST 2021, time=2021-12-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1025556, encodeId=3464102555605, content=干细胞是热点,但是进入临床仍然需要时间和临床疗效验证哦, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=独孤立克, createdTime=Sun May 09 09:43:50 CST 2021, time=2021-05-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=963830, encodeId=0e0296383063, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210429/8da6ab30060d4d2888a9391e7841ba9f/8ccaefbfbd5c4ffc894c701c25480509.jpg, createdBy=a8c15489647, createdName=小斑鱼, createdTime=Sat May 08 22:57:27 CST 2021, time=2021-05-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1347551, encodeId=688e134e551ec, content=<a href='/topic/show?id=88713e938c1' target=_blank style='color:#2F92EE;'>#发育#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37938, encryptionId=88713e938c1, topicName=发育)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f4c124, createdName=neurowu, createdTime=Sat May 08 00:43:50 CST 2021, time=2021-05-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1374312, encodeId=ec5413e4312d9, content=<a href='/topic/show?id=33615e160c1' target=_blank style='color:#2F92EE;'>#支气管肺发育不良#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=57160, encryptionId=33615e160c1, topicName=支气管肺发育不良)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=598a379, createdName=photoman, createdTime=Sat May 08 00:43:50 CST 2021, time=2021-05-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1568005, encodeId=75a8156800525, content=<a href='/topic/show?id=7a833e94079' target=_blank style='color:#2F92EE;'>#发育不良#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37940, encryptionId=7a833e94079, topicName=发育不良)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=30b515313716, createdName=villahu, createdTime=Sat May 08 00:43:50 CST 2021, time=2021-05-08, status=1, ipAttribution=)]
    2021-05-09 独孤立克

    干细胞是热点,但是进入临床仍然需要时间和临床疗效验证哦

    0

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    2021-05-08 小斑鱼

    学习了

    0

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    2021-05-08 neurowu
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