Ann Rheum Dis:抑郁和焦虑减少类风湿关节炎和银屑病关节炎缓解的可能性?

2017-07-22 xiangting MedSci原创

在RA和PsA患者中抑郁和焦虑可能会降低基于综合评分的关节缓解的可能性。

这项研究旨在探讨基线抑郁/焦虑对类风湿关节炎(RA)和银屑病关节炎(PsA)达到关节缓解可能性的预测价值,以及基线抑郁/焦虑与随访中缓解标准组成部分之间的关联。

研究人员从前瞻性观察性NOR-DMARD研究中纳入初次使用肿瘤坏死因子抑制剂或甲氨蝶呤的1326例RA患者和728例PsA患者。使用预先指定的logistic回归模型探讨抑郁/焦虑对缓解的预测价值,使用预先指定的多元线性回归模型分析基准抑郁/焦虑与缓解标准组成部分之间的关联。 

根据EuroQoL-5D-3L、简表-36(SF-36)心理健康子量表≤56和SF-36心理成分小结≤38的基线抑郁/焦虑可以预测28关节疾病活动评分<2.6,简化疾病活动指数≤3.3,临床疾病活动指数≤2.8,ACR / EULAR银屑病关节炎疾病活动指数≤4,治疗3和6个月后RA缓解(p≤0.008),PsA部分缓解(p从0.001到0.73)。基线抑郁/焦虑与RA随访期间患者和评估者总体评估、肿胀关节计数和关节疼痛升高相关,但不与肿胀关节计数和急性期反应相关。

在RA和PsA患者中抑郁和焦虑可能会降低基于综合评分的关节缓解的可能性,在对个体化患者共同决策制定治疗目标时应考虑在内。

原始出处:

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    2017-07-24 lmm397
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    2017-07-22 1e0f8808m18(暂无匿称)

    学习了,分享快乐。

    0

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    2017-07-22 清风拂面

    谢谢分享学习了

    0

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    2017-07-22 zt123

    你在哪里

    0

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CZP + MTX的标准或降低频率剂量之间没有临床意义上的差异;与CZP停药相比,两者均更有效地控制了类风湿关节炎。

J Rheumatol:类风湿关节炎滑膜病理学与MRI异常之间的关系

磁共振成像(MRI)已被越来越多地认为是评估类风湿性关节炎(RA)的关键工具,可以可靠地识别滑膜炎、骨髓水肿、骨侵蚀和关节间隙狭窄(JSN)/软骨缺失。