JAHA:纤维性肌发育不良患者性别与颈动脉夹层之间的相关性

2021-05-17 MedSci原创 MedSci原创

在FMD患者中,除其他既往已知的危险因素外,男性和多部位受累也与CeAD有关。

颈动脉夹层(CeAD)是纤维肌发育不良(FMD)患者较为常见的临床表现。但是,CeAD的危险因素尚未明确。

近日,血管疾病领域权威杂志JAHA上发表了一篇研究文章,研究人员在肾脏和颈动脉发育不良评估(ARCADIA)登记中心调查了与CeAD相关的因素。

ARCADIA登记中心纳入了年龄≥18岁,诊断为肾、颈或颅内动脉FMD的女性或男性,这些参与者是从法国和比利时的16所大学教学医院中前瞻性招募的。根据诊断标准,在影像学检查中确定了急性或既往CeAD的诊断。研究人员通过Logisitic回归分析对潜在决定因素与CeAD之间的关联进行了评估。

在469名FMD患者(75名男性)中,65名(13.9%)患者伴有CeAD。与没有CeAD的患者相比,CeAD患者更年轻,更有可能为男性,以及伴有偏头痛史,且无高血压病史。在多变量分析中,男性(比值比[OR]为2.66;95%CI为1.34-5.25)、偏头痛病史(OR为1.90;95%CI为1.06-3.39)、年龄≥50岁(OR为0.41;95%CI为0.23-0.73)、高血压病史(OR为0.35;95%CI为0.20-0.64)、3处以上血管床受累(OR为2.49;95%CI为1.15-5.40)与CeAD之间显著相关。为了验证CeAD与性别之间的关联,研究人员进行了系统评价,从2篇已发表的研究中收集了有关性别的其他数据,并从美国纤维肌发育不良登记中心和欧洲/国际FMD登记中心收集了未发表的数据。在汇总分析(289例CeAD病例,1933例患者)中,男性与CeAD之间显著相关(OR为2.04;95%CI为1.41-2.95;I2=0%)。

由此可见,在FMD患者中,除其他既往已知的危险因素外,男性和多部位受累也与CeAD有关

原始出处:

Charlotte Arnaud.et al.Male Sex Is Associated With Cervical Artery Dissection in Patients With Fibromuscular Dysplasia.J AM HEART ASSOC.2021.https://www.ahajournals.org/doi/10.1161/JAHA.120.018311

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    2021-05-19 zhaohui6731
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    2021-05-19 neurowu
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    2021-05-18 汉水人家

    学习学习

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Neurology:动脉闭塞独立预测颈动脉夹层患者的不良结果

由此可见,DAO可独立预测CeAD患者较差的功能结局。特别是对于DAO患者,有必要进一步研究血管通畅性、侧支状态和血运重建疗法的效果。

Stroke:血管迂曲可能与颈动脉夹层相关

夹层是缺血性卒中越来越公认的原因,一般为自发性发生或创伤后发生,并且患者相对年轻。研究人员推测可能存在减弱血管壁的诱发因素,动脉迂曲可能在夹层患者中发生率较高。 研究人员连续纳入了颈动脉夹层(CerAD)患者,这些患者都接受了磁共振血管造影。在一项常规健康检查中,接受磁共振血管造影的年龄和性别相匹配的健康受试者作为对照。迂曲是通过颈动脉和椎动脉(VA)动脉半自动测量获得的。迂曲指数被定义

Neurology:老年颈动脉夹层患者更易误诊

目的:在一组诊断为颈动脉夹层的患者(CeAD),确定年龄≥60岁患者的比例,并且比较年龄≥60岁及<60岁患者的特征的频率特性(症状、危险因素和预后)。方法:研究者结合确诊为CeAD的三大队列研究中患者的数据(即颈动脉夹层与缺血性卒中患者联盟)。研究者将病例分为年龄≥60岁和<60岁这两组,并比较两组间临床特点、危险因素、血管特征及3个月预后。首先,研究者对汇集个别病人的数据进行汇总分析。在每个队

Stroke:颈动脉夹层合并肌纤维发育不良患者的临床特征

观察性研究表明肌纤维发育不良与自发性颈动脉夹层(sCeAD)有关。然而,这两种疾病并存的患者是否具有鲜明的临床特征尚未得到广泛的研究。

Stroke:血管迂曲与颈动脉夹层相关

由此可见,颈动脉迂曲与颈动脉夹层相关,这可能意味着在这些患者中颈部血管结构较为薄弱。

Stroke:颈动脉夹层串联病变的机械取栓

从技术上来讲,前循环串联病变采用血管内血栓切除术是一项挑战,但是HERMES工作组发现串联病变和孤立性颅内闭塞的预后类似。颈总动脉狭窄-闭塞的2个重要的病因为动脉粥样硬化和动脉夹层,这两项病因对血管内治疗后再灌注和临床预后的影响尚不清楚。