J Periodontol:男性睾酮的水平与牙周炎的发生发展有关

2015-06-21 MedSci MedSci原创

J Periodontol:男性睾酮的水平与牙周炎的发生发展有关性激素与炎症以及骨代谢有关。本研究的目的是为了探讨男性性激素与牙周炎之间的关系。数据来源于第三次国民健康和营养调查(NHANES)。分析755名男性(年龄≥30岁)的血清睾酮,雌二醇,性激素结合球蛋白(SHBG)以及雄烯二醇葡萄糖苷酸(AAG)的水平。计算睾固酮以及雌二醇睾酮比值。使用最新牙周炎累及范围和严重程度分类来评估研究对象的牙





性激素与炎症以及骨代谢有关。本研究的目的是为了探讨男性性激素与牙周炎之间的关系。数据来源于第三次国民健康和营养调查(NHANES)。

分析755名男性(年龄≥30岁)的血清睾酮,雌二醇,性激素结合球蛋白(SHBG)以及雄烯二醇葡萄糖苷酸(AAG)的水平。计算睾固酮以及雌二醇睾酮比值。使用最新牙周炎累及范围和严重程度分类来评估研究对象的牙周炎状况(≥2个邻接区附着丧失≥3mm以及≥2邻接区牙周袋探诊深度≥4mm或者1个位点牙周袋探诊深度≥5mm)。性激素为分类变量和连续变量。通过牙周炎的严重程度与性激素水平的比值比来确定二者之间的关系。

校正了混杂因素后,高水平的总睾酮以及睪固酮与牙周炎的患病率【总睾酮(OR : 2.1 ,95%CI:1-4.5),睾固酮(OR : 3.9 ,95%CI:1-14.8)】及严重程度【 总睾酮(OR: 2.1,95%CI:1-4.3),睾固酮(OR : 3.4 ,95%CI:1.2-9.8)】有关。性激素作为连续变量时,总睾酮与牙周炎患病率关系则为OR:1.4,95% CI:0.6-3.3,与牙周炎严重程度关系为OR:1.5,95% CI:0.6-3.6;睾固酮与牙周炎患病率则为OR:1.3,95%CI:0.9-1.9,与牙周炎严重程度则为OR:1.3 ,95%CI:0.9-1.8。

本研究的发现与既往研究表明激素与牙周炎相关的结果一致,本文着重探讨了男性睾酮与牙周炎患病率及严重程度之间有关。

原始出处:

Steffens JP, Wang X, Starr JR, Spolidorio LC, Van Dyke TE, Kantarci A.Associations Between Sex Hormone Levels and Periodontitis in Men: Results From Nhanes Iii.J Periodontol. 2015 Jun 11:1-14.

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    2016-09-13 1e10c84am36(暂无匿称)

    好文章,还会关注

    0

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  3. [GetPortalCommentsPageByObjectIdResponse(id=125046, encodeId=decb1250464b, content=好文章,还会关注, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzdAIB7UwTkHt6fQkBP8ictliaXtc5gCUmYdAW1sAETC2nhO3q6YjRHkUibyOCtP8ibmXNObTyd63A076/0, createdBy=d4111948983, createdName=1e10c84am36(暂无匿称), createdTime=Tue Sep 13 11:51:00 CST 2016, time=2016-09-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2030717, encodeId=99ee2030e1760, content=<a href='/topic/show?id=71353e8964f' target=_blank style='color:#2F92EE;'>#发生发展#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37896, encryptionId=71353e8964f, topicName=发生发展)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=346311, createdName=wgsun, createdTime=Wed Dec 02 18:16:00 CST 2015, time=2015-12-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1725863, encodeId=e79c1e25863b2, content=<a href='/topic/show?id=986913980dd' target=_blank style='color:#2F92EE;'>#PE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13980, encryptionId=986913980dd, topicName=PE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f06c33759375, createdName=feather89, createdTime=Tue Jan 12 05:16:00 CST 2016, time=2016-01-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=35105, encodeId=49173510560, content=期待有更多研究, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=332823945, createdName=hlycom3356, createdTime=Thu Aug 06 23:10:00 CST 2015, time=2015-08-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=29438, encodeId=a64d294382b, content=好扯, beContent=null, objectType=article, channel=null, level=null, likeNumber=159, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=48ce1618316, createdName=stupidox, createdTime=Fri Jun 26 07:04:00 CST 2015, time=2015-06-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1450421, encodeId=985f145042102, content=<a href='/topic/show?id=f0476e49582' target=_blank style='color:#2F92EE;'>#牙周#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67495, encryptionId=f0476e49582, topicName=牙周)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ab585558129, createdName=liuyong2982, createdTime=Tue Jun 23 05:16:00 CST 2015, time=2015-06-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=28656, encodeId=eaa028656db, content=呵呵, beContent=null, objectType=article, channel=null, level=null, likeNumber=117, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=66c61628089, createdName=caierhong, createdTime=Mon Jun 22 23:22:00 CST 2015, time=2015-06-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=28643, encodeId=003b28643f3, content=厉害, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ed101627734, createdName=Messichen1992, createdTime=Mon Jun 22 14:00:00 CST 2015, time=2015-06-22, status=1, ipAttribution=)]
    2016-01-12 feather89
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    2015-08-06 hlycom3356

    期待有更多研究

    0

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    2015-06-26 stupidox

    好扯

    0

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    2015-06-22 caierhong

    呵呵

    0

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    2015-06-22 Messichen1992

    厉害

    0

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