Diabetes Care:2型糖尿病患者顽固性高血压的预后意义

2019-10-18 xing.T MedSci原创

由此可见,在2型糖尿病患者中,aRHT的存在提示心血管疾病和死亡率的风险增加,并且基于ABPM的分类可预测肾脏结局并改善心血管/死亡率危险分层。

近日,糖尿病领域权威杂志Diabetes Care上发表了一篇研究文章,研究人员旨在评估2型糖尿病个体顽固性高血压(RHT)对并发症发展的预后重要性。

646例患者在随访的第一年内,根据平均诊室血压(BP)的水平被诊断为明显的顽固性高血压(aRHT)。研究人员使用传统的BP临界值和新的2017年美国心脏病学会(ACC)/美国心脏协会(AHA)标准,并根据24小时动态BP监测(ABPM)结果,将它们重新分类为白大衣/对照或真/非对照RHT 。多变量Cox分析评估了RHT诊断与微血管和心血管并发症、全因和心血管死亡率之间的关联。

在10年的中位随访中,有177例患者发生了心血管事件(145例严重)。222例患者死亡(101例心血管疾病);200名患者有肾脏事件;156例发生视网膜病变;174名患者发生了神经病变。对于非RHT个人,aRHT(按传统和新标准分别占44.6%和50%)预测了所有心血管和死亡率结局,风险比(HRs)在1.64和2.16之间,但没有微血管结局。真正的RHT增加了HR(从1.81到2.25),并预测了肾脏的预后。白大衣/对照RHT意味着风险增加(HR:1.33–1.86),这是非RHT和真实RHT个体之间的介导因素。使用传统和新的ACC/AHA标准进行分类结果类似。

由此可见,在2型糖尿病患者中,aRHT的存在提示心血管疾病和死亡率的风险增加,并且基于ABPM的分类可预测肾脏结局并改善心血管/死亡率危险分层。

原始出处:


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  5. 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  6. 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  7. 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  8. 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GetPortalCommentsPageByObjectIdResponse(id=374099, encodeId=2ac83e4099c1, content=好, beContent=null, objectType=article, channel=null, level=null, likeNumber=101, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6d551998554, createdName=1e1c07bdm01(暂无匿称), createdTime=Sat Oct 19 06:31:08 CST 2019, time=2019-10-19, status=1, ipAttribution=)]
    2019-10-19 一天没事干

    很好的学习机会

    0

  9. 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GetPortalCommentsPageByObjectIdResponse(id=374099, encodeId=2ac83e4099c1, content=好, beContent=null, objectType=article, channel=null, level=null, likeNumber=101, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6d551998554, createdName=1e1c07bdm01(暂无匿称), createdTime=Sat Oct 19 06:31:08 CST 2019, time=2019-10-19, status=1, ipAttribution=)]
    2019-10-19 yjs木玉

    好好好好好好

    0

  10. 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