Int J Cardiol:血浆游离甲状腺素较高与老年男性主要心血管事件的发生率增加有关!

2017-10-30 xing.T MedSci原创

这项研究表明血浆FT4水平较高但尚未达到当前甲亢诊断标准的老年男性发生主要心血管事件的风险增加。

近日,心血管领域权威杂志International Journal of Cardiology上发表了一篇研究文章,这项研究旨在评估没有已知甲状腺疾病的社区老年男性血清中游离甲状腺素(FT4)和血清甲状腺促激素(TSH)浓度与既往诊断的心血管疾病和新发心血管事件发生率之间的相关性。

这项研究涉及一群没有已知甲状腺疾病的社区招募的老年男性。研究人员采用免疫分析法测定了血浆中FT4和TSH水平,过去诊断心血管疾病是通过问卷调查数据来确定的。研究人员使用西澳大利亚数据关联系统评估了受试者的主要心血管事件发生率,并采用Logistic回归分析和Cox比例风险分析评估了血浆中FT4和TSH与既往心血管疾病诊断和新发的主要心血管事件(心血管死亡、心肌梗死卒中)发生率的关系。

研究人员对3712名男子平均随访9.5年。研究人员发现血浆FT4水平位于最好四分位数范围的个体相比其他受试者,既往更可能已被确诊为心血管疾病,但这种相关性在将其他危险因素进行调整后就不再显著。血浆FT4水平位于最好四分位数范围的男性,相比其他男性,主要心血管事件(调整后的风险比为1.15,95%可信区间为1-1.31)和心肌梗死(调整后的风险比为1.29,95%可信区间为1.06-1.54)发生率增加。

这项研究表明血浆FT4水平较高但尚未达到当前甲亢诊断标准的老年男性发生主要心血管事件的风险增加。

原始出处:

Jonathan Golledgea, et al. Plasma free thyroxine in the upper quartile is associated with an increased incidence of major cardiovascular events in older men that do not have thyroid dysfunction according to conventional criteria.International Journal of Cardiology.2017. https://doi.org/10.1016/j.ijcard.2017.10.100

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    2017-11-04 虈亣靌

    谢谢分享谢谢分享

    0

  6. 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  8. 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objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160718/IMG578C993D395567540.jpg, createdBy=59b81918946, createdName=flysky120, createdTime=Tue Oct 31 10:59:21 CST 2017, time=2017-10-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=257483, encodeId=1c3a25e48390, content=是很好的学习材料.不错.以后会多学习., beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Tue Oct 31 10:46:29 CST 2017, time=2017-10-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=257470, encodeId=242425e4704a, content=学习了谢谢了, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLPeNmuNF9ibgMfMOAs7Iic5MpiaU8RLmRH67xCKuk5wzfhb7G4ib7ia6z9lrnsTicj1nAUfEOMecZDtvvu/0, createdBy=d7f91939785, createdName=186****0580(小山羊), createdTime=Tue Oct 31 09:58:56 CST 2017, time=2017-10-31, status=1, ipAttribution=)]
    2017-10-31 flysky120

    学习一下知识了

    0

  9. 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objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160718/IMG578C993D395567540.jpg, createdBy=59b81918946, createdName=flysky120, createdTime=Tue Oct 31 10:59:21 CST 2017, time=2017-10-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=257483, encodeId=1c3a25e48390, content=是很好的学习材料.不错.以后会多学习., beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Tue Oct 31 10:46:29 CST 2017, time=2017-10-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=257470, encodeId=242425e4704a, content=学习了谢谢了, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLPeNmuNF9ibgMfMOAs7Iic5MpiaU8RLmRH67xCKuk5wzfhb7G4ib7ia6z9lrnsTicj1nAUfEOMecZDtvvu/0, createdBy=d7f91939785, createdName=186****0580(小山羊), createdTime=Tue Oct 31 09:58:56 CST 2017, time=2017-10-31, status=1, ipAttribution=)]
    2017-10-31 虈亣靌

    是很好的学习材料.不错.以后会多学习.

    0

  10. 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objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160718/IMG578C993D395567540.jpg, createdBy=59b81918946, createdName=flysky120, createdTime=Tue Oct 31 10:59:21 CST 2017, time=2017-10-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=257483, encodeId=1c3a25e48390, content=是很好的学习材料.不错.以后会多学习., beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Tue Oct 31 10:46:29 CST 2017, time=2017-10-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=257470, encodeId=242425e4704a, content=学习了谢谢了, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLPeNmuNF9ibgMfMOAs7Iic5MpiaU8RLmRH67xCKuk5wzfhb7G4ib7ia6z9lrnsTicj1nAUfEOMecZDtvvu/0, createdBy=d7f91939785, createdName=186****0580(小山羊), createdTime=Tue Oct 31 09:58:56 CST 2017, time=2017-10-31, status=1, ipAttribution=)]
    2017-10-31 186****0580(小山羊)

    学习了谢谢了

    0

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测定甲状腺功能是测定FT4还是FT3呢?

甲状腺激素测定包括TT4、TT3、FT4、FT3及TSH。血中的T4、T3 中99%以上与蛋白结合,进入细胞内发挥作用的占总激素不到1%的游离激素。怀孕、肝功能损害等导致结合蛋白浓度改变对总激素浓度测定产生很大影响,而游离激素的浓度基本不受影响,因此游离激素可判断甲状腺激素过多、不足。