J Matern Fetal Neonatal Med:挤压脐带不会加重早产儿胎膜早破或其他不良并发症的发生

2020-10-04 MedSci原创 MedSci原创

本研究旨在探讨挤压脐带(I-UCM)是否会加重早产儿胎膜早破(PPROM)的感染或导致其他不良并发症,研究结果已在线发表于J Matern Fetal Neonatal Med。

早产儿延迟断脐可通过增加新生儿循环血容量降低新生儿贫血、输血需求、坏死性小肠结肠炎,以及脑室内出血的发生风险。然而,对于早产儿,用脐带挤压替代延迟断脐的干预效果尚不清楚。该研究以新生儿红细胞压积作为主要结局,以脑室内出血、坏死性小肠结肠炎和输血需求的发生率为次要结局,比较二者对早产儿影响的区别。

2019年5月,《美国产科与妇科学杂志》(American Journal of Obstetrics and Gynecology)发表了一项比较延迟断脐和脐带挤压对早产儿影响的非盲随机对照试验。结果显示,脐带挤压可能是延迟断脐的一种可取的替代方法,因为二者对新生儿红细胞压积和输血需求的影响相似,并且不会增加新生儿并发症和发病率的风险。本研究提示,脐带挤压可能作为一种及时有效的方法增加婴儿血容量。

本研究旨在探讨挤压脐带(I-UCM)是否会加重早产儿胎膜早破(PPROM)的感染或导致其他不良并发症,研究结果已在线发表于J Matern Fetal Neonatal Med。

将妊娠28~37周之间经阴道分娩且出生前并发PPROM的新生儿,根据脐带夹持程序随机分为两组:夹脐带前的I-UCM和立即夹脐带(ICC)。对两组研究对象的各项参数进行比较。

结果显示,102名早产儿中,分别有48名和54名早产儿被随机分配到I-UCM组和ICC组。两组患儿在血液学参数(血小板计数、白血球计数、中性粒细胞比值和C-反应蛋白)或新生儿结局(可能或一定的新生儿感染、呼吸窘迫综合征、坏死性肠炎和静脉内出血)方面没有显著差异(P > .05)。然而,与ICC组相比,I-UCM组早产新生儿的血清血红蛋白和血细胞比容水平较高(p < .05),接受的输血量较少(p < .05)。

综上所述,该研究结果表明,对患有PPROM的早产新生儿进行挤压脐带不会加重新生儿感染或导致其他不良并发症。这个简单的程序将改善血红蛋白值和血细胞比容水平,并可减少新生儿期输血的需要。

原始出处:

Juan LiBo Yu, et al., Does intact umbilical cord milking increase infection rates in preterm infants with premature prolonged rupture of membranes? J Matern Fetal Neonatal Med. 2020 Jan;33(2):184-190. doi: 10.1080/14767058.2018.1487947. 

Shirk SK, Manolis SA, Lambers DS, et al. Delayed clamping vs milking of umbilical cord in preterm infants: a randomized controlled trial[J]. Am J Obstet Gynecol, 2019,220(5):482.e1-482.e8. DOI: 10.1016/j.ajog.2019.01.234

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    2021-09-02 丁鹏鹏
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    2021-01-17 liye789132251
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    2021-03-02 若水123
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  5. [GetPortalCommentsPageByObjectIdResponse(id=1758288, encodeId=f4991e58288d7, content=<a href='/topic/show?id=84ba49031f9' target=_blank style='color:#2F92EE;'>#并发#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=49031, encryptionId=84ba49031f9, topicName=并发)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a27e37327108, createdName=丁鹏鹏, createdTime=Thu Sep 02 18:54:06 CST 2021, time=2021-09-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1884702, encodeId=c2521884e0226, content=<a href='/topic/show?id=3b2112532d8' target=_blank style='color:#2F92EE;'>#Nat#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12532, encryptionId=3b2112532d8, topicName=Nat)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e6f107, createdName=liye789132251, createdTime=Sun Jan 17 23:54:06 CST 2021, time=2021-01-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1985289, encodeId=ad97198528918, content=<a href='/topic/show?id=18f612646a4' target=_blank style='color:#2F92EE;'>#Neon#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12646, encryptionId=18f612646a4, topicName=Neon)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTIOca9icPByKxo3ZRUrvuibf7tWt7EScQ1NEiaKy4NCUctSU2jDjOayLicDIaicwUxaQhJ1SZKdEevgjRg/132, createdBy=4f272500131, createdName=若水123, createdTime=Tue Mar 02 05:54:06 CST 2021, time=2021-03-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1440307, encodeId=0f74144030ef1, content=<a href='/topic/show?id=d05e836826f' target=_blank style='color:#2F92EE;'>#胎膜早破#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83682, encryptionId=d05e836826f, topicName=胎膜早破)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=96e34724057, createdName=ms6519009802973839, createdTime=Tue Oct 06 09:54:06 CST 2020, time=2020-10-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1466100, encodeId=e9601466100b6, content=<a href='/topic/show?id=217c292009' target=_blank style='color:#2F92EE;'>#ATA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2920, encryptionId=217c292009, topicName=ATA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=387a6772119, createdName=bbjsj_1981, createdTime=Tue Oct 06 09:54:06 CST 2020, time=2020-10-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1542427, encodeId=0f53154242e54, content=<a href='/topic/show?id=82c0846654a' target=_blank style='color:#2F92EE;'>#脐带#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84665, encryptionId=82c0846654a, topicName=脐带)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f06713409761, createdName=1249859em42(暂无昵称), createdTime=Tue Oct 06 09:54:06 CST 2020, time=2020-10-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1610739, encodeId=b3841610e3911, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Tue Oct 06 09:54:06 CST 2020, time=2020-10-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=890151, encodeId=6756890151b2, content=收藏, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4b972455532, createdName=1240394fm61暂无昵称, createdTime=Mon Oct 05 06:55:43 CST 2020, time=2020-10-05, status=1, ipAttribution=)]
    2020-10-06 bbjsj_1981
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