阜外医院吴永健等报告,冠脉“一站式”杂交治疗患者,术前贫血增3.3倍急性肾损伤风险

2019-05-21 佚名 中国循环杂志

阜外医院吴永健教授团队发表的一项单中心研究显示,在“一站式”杂交冠脉血运重建术后患者中,14.6%出现急性肾损伤,其中86.1%发生在术后72小时内,大部分可完全恢复。 多因素回归分析显示,术前贫血是“一站式”杂交冠脉血运重建术后出现急性肾损伤的危险因素(OR=4.303,95%CI:1.859~9.963,P=0.001)


阜外医院吴永健教授团队发表的一项单中心研究显示,在“一站式”杂交冠脉血运重建术后患者中,14.6%出现急性肾损伤,其中86.1%发生在术后72小时内,大部分可完全恢复。

多因素回归分析显示,术前贫血是“一站式”杂交冠脉血运重建术后出现急性肾损伤的危险因素(OR=4.303,95%CI:1.859~9.963,P=0.001)。

研究者指出,该研究显示,急性肾损伤是“一站式”杂交冠脉血运重建术后常见并发症。本研究中急性肾损伤发生率(14.6%)低于既往报道的对比剂相关或心脏搭桥术相关急性肾损伤发生率。

这可能与阜外医院在该研究回顾的时间段内已弃用高渗造影剂、广泛使用等渗或低渗对比剂相关,且患者术中血流动力学状况维持较为平稳,保证了重要脏器及肾脏的灌注,从而减少急性肾损伤发生。这可能也是该研究中30天复查时肾功能完全恢复比例较高的原因。

对于术前贫血的患者,应重视术后早期急性肾损伤的预防,更密切监测患者肾功能的变化。

该研究中,急性肾损伤定义为(满足以下一项):(1)术后48小时血肌酐升高≥0.3mg/dl;(2)7天内血肌酐较基线升高1.5倍;(3)6小时尿量≤0.5ml/(kg·h)。

该研究连续入选2014年1月至2016年12月于阜外医院行一站式杂交冠脉血运重建术的199例患者,患者平均年龄60岁。

患者术前平均估计肾小球滤过率为81.76ml/(min·1.73m2),术前合并慢性肾功能不全患者19例,合并贫血患者40例。

术后出现急性肾损伤的患者有14.6%,其中Ⅰ期89.7%,Ⅱ期6.9%,Ⅲ期3.4%。其中,术后72h发生的急性肾损伤占86.1%。术后30天,所有患者的急性肾损伤均完全恢复。

版权声明:
本网站所有内容来源注明为“梅斯医学”或“MedSci原创”的文字、图片和音视频资料,版权均属于梅斯医学所有。非经授权,任何媒体、网站或个人不得转载,授权转载时须注明来源为“梅斯医学”。其它来源的文章系转载文章,或“梅斯号”自媒体发布的文章,仅系出于传递更多信息之目的,本站仅负责审核内容合规,其内容不代表本站立场,本站不负责内容的准确性和版权。如果存在侵权、或不希望被转载的媒体或个人可与我们联系,我们将立即进行删除处理。
在此留言
评论区 (5)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=1951816, encodeId=8fc319518169a, content=<a href='/topic/show?id=7df11938efe' target=_blank style='color:#2F92EE;'>#一站式#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=19387, encryptionId=7df11938efe, topicName=一站式)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=743b215, createdName=fusion, createdTime=Fri Feb 21 20:45:00 CST 2020, time=2020-02-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1970157, encodeId=fdcb19e015749, content=<a href='/topic/show?id=1efe6102ef4' target=_blank style='color:#2F92EE;'>#术前贫血#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=61027, encryptionId=1efe6102ef4, topicName=术前贫血)], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160723/IMG57937A3BB59F33185.jpg, createdBy=7642322, createdName=手留余香, createdTime=Thu Apr 16 18:45:00 CST 2020, time=2020-04-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1816109, encodeId=aefb181610929, content=<a href='/topic/show?id=fc4e9e348b6' target=_blank style='color:#2F92EE;'>#阜外医#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97348, encryptionId=fc4e9e348b6, topicName=阜外医)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c97a2500111, createdName=thinkibmz_44722594, createdTime=Fri Jun 07 13:45:00 CST 2019, time=2019-06-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1293704, encodeId=d0f71293e040e, content=<a href='/topic/show?id=4c6e9e34931' target=_blank style='color:#2F92EE;'>#阜外医院#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97349, encryptionId=4c6e9e34931, topicName=阜外医院)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8942242, createdName=jj000001, createdTime=Thu May 23 12:45:00 CST 2019, time=2019-05-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1397761, encodeId=325f139e76134, content=<a href='/topic/show?id=8bee565436d' target=_blank style='color:#2F92EE;'>#损伤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=56543, encryptionId=8bee565436d, topicName=损伤)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83eoNX3lUOlDKGBUEPNwZx0nibmdcFyeibnX4WMhUSCU2REpGRWtSmnT2CCs0dA5waxvJknYDxwtYnIcQ/132, createdBy=294e2500218, createdName=ms3046638856685384, createdTime=Thu May 23 12:45:00 CST 2019, time=2019-05-23, status=1, ipAttribution=)]
    2020-02-21 fusion
  2. [GetPortalCommentsPageByObjectIdResponse(id=1951816, encodeId=8fc319518169a, content=<a href='/topic/show?id=7df11938efe' target=_blank style='color:#2F92EE;'>#一站式#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=19387, encryptionId=7df11938efe, topicName=一站式)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=743b215, createdName=fusion, createdTime=Fri Feb 21 20:45:00 CST 2020, time=2020-02-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1970157, encodeId=fdcb19e015749, content=<a href='/topic/show?id=1efe6102ef4' target=_blank style='color:#2F92EE;'>#术前贫血#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=61027, encryptionId=1efe6102ef4, topicName=术前贫血)], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160723/IMG57937A3BB59F33185.jpg, createdBy=7642322, createdName=手留余香, createdTime=Thu Apr 16 18:45:00 CST 2020, time=2020-04-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1816109, encodeId=aefb181610929, content=<a href='/topic/show?id=fc4e9e348b6' target=_blank style='color:#2F92EE;'>#阜外医#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97348, encryptionId=fc4e9e348b6, topicName=阜外医)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c97a2500111, createdName=thinkibmz_44722594, createdTime=Fri Jun 07 13:45:00 CST 2019, time=2019-06-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1293704, encodeId=d0f71293e040e, content=<a href='/topic/show?id=4c6e9e34931' target=_blank style='color:#2F92EE;'>#阜外医院#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97349, encryptionId=4c6e9e34931, topicName=阜外医院)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8942242, createdName=jj000001, createdTime=Thu May 23 12:45:00 CST 2019, time=2019-05-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1397761, encodeId=325f139e76134, content=<a href='/topic/show?id=8bee565436d' target=_blank style='color:#2F92EE;'>#损伤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=56543, encryptionId=8bee565436d, topicName=损伤)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83eoNX3lUOlDKGBUEPNwZx0nibmdcFyeibnX4WMhUSCU2REpGRWtSmnT2CCs0dA5waxvJknYDxwtYnIcQ/132, createdBy=294e2500218, createdName=ms3046638856685384, createdTime=Thu May 23 12:45:00 CST 2019, time=2019-05-23, status=1, ipAttribution=)]
  3. [GetPortalCommentsPageByObjectIdResponse(id=1951816, encodeId=8fc319518169a, content=<a href='/topic/show?id=7df11938efe' target=_blank style='color:#2F92EE;'>#一站式#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=19387, encryptionId=7df11938efe, topicName=一站式)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=743b215, createdName=fusion, createdTime=Fri Feb 21 20:45:00 CST 2020, time=2020-02-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1970157, encodeId=fdcb19e015749, content=<a href='/topic/show?id=1efe6102ef4' target=_blank style='color:#2F92EE;'>#术前贫血#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=61027, encryptionId=1efe6102ef4, topicName=术前贫血)], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160723/IMG57937A3BB59F33185.jpg, createdBy=7642322, createdName=手留余香, createdTime=Thu Apr 16 18:45:00 CST 2020, time=2020-04-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1816109, encodeId=aefb181610929, content=<a href='/topic/show?id=fc4e9e348b6' target=_blank style='color:#2F92EE;'>#阜外医#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97348, encryptionId=fc4e9e348b6, topicName=阜外医)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c97a2500111, createdName=thinkibmz_44722594, createdTime=Fri Jun 07 13:45:00 CST 2019, time=2019-06-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1293704, encodeId=d0f71293e040e, content=<a href='/topic/show?id=4c6e9e34931' target=_blank style='color:#2F92EE;'>#阜外医院#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97349, encryptionId=4c6e9e34931, topicName=阜外医院)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8942242, createdName=jj000001, createdTime=Thu May 23 12:45:00 CST 2019, time=2019-05-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1397761, encodeId=325f139e76134, content=<a href='/topic/show?id=8bee565436d' target=_blank style='color:#2F92EE;'>#损伤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=56543, encryptionId=8bee565436d, topicName=损伤)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83eoNX3lUOlDKGBUEPNwZx0nibmdcFyeibnX4WMhUSCU2REpGRWtSmnT2CCs0dA5waxvJknYDxwtYnIcQ/132, createdBy=294e2500218, createdName=ms3046638856685384, createdTime=Thu May 23 12:45:00 CST 2019, time=2019-05-23, status=1, ipAttribution=)]
  4. [GetPortalCommentsPageByObjectIdResponse(id=1951816, encodeId=8fc319518169a, content=<a href='/topic/show?id=7df11938efe' target=_blank style='color:#2F92EE;'>#一站式#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=19387, encryptionId=7df11938efe, topicName=一站式)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=743b215, createdName=fusion, createdTime=Fri Feb 21 20:45:00 CST 2020, time=2020-02-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1970157, encodeId=fdcb19e015749, content=<a href='/topic/show?id=1efe6102ef4' target=_blank style='color:#2F92EE;'>#术前贫血#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=61027, encryptionId=1efe6102ef4, topicName=术前贫血)], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160723/IMG57937A3BB59F33185.jpg, createdBy=7642322, createdName=手留余香, createdTime=Thu Apr 16 18:45:00 CST 2020, time=2020-04-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1816109, encodeId=aefb181610929, content=<a href='/topic/show?id=fc4e9e348b6' target=_blank style='color:#2F92EE;'>#阜外医#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97348, encryptionId=fc4e9e348b6, topicName=阜外医)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c97a2500111, createdName=thinkibmz_44722594, createdTime=Fri Jun 07 13:45:00 CST 2019, time=2019-06-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1293704, encodeId=d0f71293e040e, content=<a href='/topic/show?id=4c6e9e34931' target=_blank style='color:#2F92EE;'>#阜外医院#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97349, encryptionId=4c6e9e34931, topicName=阜外医院)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8942242, createdName=jj000001, createdTime=Thu May 23 12:45:00 CST 2019, time=2019-05-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1397761, encodeId=325f139e76134, content=<a href='/topic/show?id=8bee565436d' target=_blank style='color:#2F92EE;'>#损伤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=56543, encryptionId=8bee565436d, topicName=损伤)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83eoNX3lUOlDKGBUEPNwZx0nibmdcFyeibnX4WMhUSCU2REpGRWtSmnT2CCs0dA5waxvJknYDxwtYnIcQ/132, createdBy=294e2500218, createdName=ms3046638856685384, createdTime=Thu May 23 12:45:00 CST 2019, time=2019-05-23, status=1, ipAttribution=)]
  5. [GetPortalCommentsPageByObjectIdResponse(id=1951816, encodeId=8fc319518169a, content=<a href='/topic/show?id=7df11938efe' target=_blank style='color:#2F92EE;'>#一站式#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=19387, encryptionId=7df11938efe, topicName=一站式)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=743b215, createdName=fusion, createdTime=Fri Feb 21 20:45:00 CST 2020, time=2020-02-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1970157, encodeId=fdcb19e015749, content=<a href='/topic/show?id=1efe6102ef4' target=_blank style='color:#2F92EE;'>#术前贫血#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=61027, encryptionId=1efe6102ef4, topicName=术前贫血)], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160723/IMG57937A3BB59F33185.jpg, createdBy=7642322, createdName=手留余香, createdTime=Thu Apr 16 18:45:00 CST 2020, time=2020-04-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1816109, encodeId=aefb181610929, content=<a href='/topic/show?id=fc4e9e348b6' target=_blank style='color:#2F92EE;'>#阜外医#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97348, encryptionId=fc4e9e348b6, topicName=阜外医)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c97a2500111, createdName=thinkibmz_44722594, createdTime=Fri Jun 07 13:45:00 CST 2019, time=2019-06-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1293704, encodeId=d0f71293e040e, content=<a href='/topic/show?id=4c6e9e34931' target=_blank style='color:#2F92EE;'>#阜外医院#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97349, encryptionId=4c6e9e34931, topicName=阜外医院)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8942242, createdName=jj000001, createdTime=Thu May 23 12:45:00 CST 2019, time=2019-05-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1397761, encodeId=325f139e76134, content=<a href='/topic/show?id=8bee565436d' target=_blank style='color:#2F92EE;'>#损伤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=56543, encryptionId=8bee565436d, topicName=损伤)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83eoNX3lUOlDKGBUEPNwZx0nibmdcFyeibnX4WMhUSCU2REpGRWtSmnT2CCs0dA5waxvJknYDxwtYnIcQ/132, createdBy=294e2500218, createdName=ms3046638856685384, createdTime=Thu May 23 12:45:00 CST 2019, time=2019-05-23, status=1, ipAttribution=)]

相关资讯

阜外医院实验诊断中心“火眼金睛”识破假性马凡综合征

20岁,男性,瘦高、细长指、晶状体异位、有皮纹、轻度二尖瓣脱垂。 2015年3月的一天,阜外医院血管外科接诊了这样一位患者。根据临床症状,高度怀疑是马凡综合征。

阜外医院赵连成等万人19年随访研究:甘油三酯越高,心脑血管事件风险就越高

即使血清 LDL-C 目在达到标水平的人仍有心血管事件的残留风险,这可能与甘油三酯(TG)水平升高有关。 阜外医院赵连成等利用中美合作研究资料,对近万人的队列人群进行了长达 19 年的随访,结果表明,基线血清TG水平较高者的冠心病事件和缺血性脑卒中事件发生率显著增加。

阜外医院首次应用KODEX-EPD成像技术实现无X射线电极导线定位植入心脏起搏器

近年来,心律失常介入治疗发展迅速,各种全三维新技术不断涌现,如何能够更快、更简便、更精细地构建出所需要的实时心脏三维结构、减少X线对介入术者和患者的损伤是技术突破的热点。 2018年12月25日,中国医学科学院阜外医院心律失常中心华伟教授等首次应用KODEX-EPDTM成像技术为一位病态窦房结综合征患者成功植入心脏起搏器。

Arthritis Research & Therapy:阜外医院大规模儿童大动脉炎研究:半数在5年内复发,肾动脉受累常见

阜外医院蔡军、张慧敏等通过分析百例儿童大动脉炎患者资料,发现儿童大动脉炎患者在诊断后的第一年内死亡率为3%,大约50%的患者在诊断后5年内至少经历过一次不良事件或再住院。

阜外医院开先河,使用虚拟现实技术培养心外医师

心脏外科学被誉为“外科皇冠上的明珠”,但应用传统的培养模式来培养一名合格的心外科医生,不仅学习曲线长,而且从观察学习者到手术者的鸿沟跨越得不太好,医疗差错发生率高。 将虚拟现实(VR)技术引入到心外科医师的培养过程中,效果如何?

CATHETER CARDIO INTE:阜外医院窦克非等研究称,介入患者血小板减少不增加出血风险

阜外医院窦克非等研究提示,接受PCI的患者中,基线血小板减少症很常见,但它不会影响预后,尤其是不会增加出血风险。