Chest:虚弱与ICU后残疾、入住护理院和死亡之间的关系!

2018-03-18 xing.T MedSci原创

由此可见,入住ICU前的虚弱状态与ICU出院后残疾和新入住护理院人数增加有关。入住ICU前的虚弱状态可能为危重病患者的预后提供预后信息。

虚弱是老年人易发生疾病的一个有力指标,但它与ICU结局之间的相关性尚未被前瞻性地评估(即ICU入院前获得的客观的指标)。近日,呼吸领域权威杂志chest上发表了一篇研究文章,研究人员的目标是前瞻性地评估虚弱和ICU后残疾、入住疗养院(NH)和死亡之间的关系。

该队列包括了754名年龄≥70岁的老年人,这些患者每月进行13项功能活动评估和每18个月评估一次虚弱性(1998-2014)。虚弱是用Fried指数来评估,该指数定义了虚弱、虚弱前期和非虚弱,分别以≥3、1-2和0分为标准。分析样本包括391个入住ICU的患者。

患者平均年龄为84岁。在391个入住ICU的患者中,虚弱和虚弱前期分别有213名(54.5%)和140名(35.8%)。相对于非虚弱,虚弱与6个月后严重残疾增加41%相关(校正RR为1.41,95%CI为1.12-1.78);虚弱前期导致严重残疾增加28%(调整后RR为1.28,95%CI为1.01-1.63)。虚弱(比值比为3.52,95%CI为1.23-10.08),但不是虚弱前期(比值比为2.01,95%CI为0.77-5.24),与NH入院增加有关。通过6个月的随访,虚弱分数每增加1分(0-5)与死亡的可能性加倍相关(风险比为2,95%CI为1.33-3)。

由此可见,入住ICU前的虚弱状态与ICU出院后残疾和新入住护理院人数增加有关。入住ICU前的虚弱状态可能为危重病患者的预后提供预后信息。

原始出处:

Lauren E. Ferrante,et al. The Association of Frailty with Post-ICU Disability, Nursing Home Admission, and Mortality: a Longitudinal Study.chest.2018. https://doi.org/10.1016/j.chest.2018.03.007

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  2. [GetPortalCommentsPageByObjectIdResponse(id=2051101, encodeId=e5bc2051101d4, content=<a href='/topic/show?id=95f8e042dd' target=_blank style='color:#2F92EE;'>#EST#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7042, encryptionId=95f8e042dd, topicName=EST)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e9a6357, createdName=xiangyuzhou971, createdTime=Sat Aug 18 04:08:00 CST 2018, time=2018-08-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1929480, encodeId=12351929480cf, content=<a href='/topic/show?id=9e604625ab' target=_blank style='color:#2F92EE;'>#Chest#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4625, encryptionId=9e604625ab, topicName=Chest)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c48a270, createdName=Smile2680, createdTime=Sun Nov 04 11:08:00 CST 2018, time=2018-11-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=297795, encodeId=94ed29e795c4, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmhead/Q3auHgzwzM6P57Bs8gOPaY1cQP9lIia0lmZOEXraGaoicqNToIslXDKw/0, createdBy=7a041951742, createdName=衣带渐宽, createdTime=Mon Mar 19 21:23:54 CST 2018, time=2018-03-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=297602, encodeId=9ea529e602e3, content=不错耶.学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3b2c1627329, createdName=owlhealth, createdTime=Mon Mar 19 07:01:18 CST 2018, time=2018-03-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=297519, encodeId=fa0829e519cb, content=虚弱是老年人易发生疾病的一个有力指标.但它与ICU结局之间的相关性尚未被前瞻性地评估(即ICU入院前获得的客观的指标).近日.呼吸领域权威杂志chest上发表了一篇研究文章.研究人员的目标是前瞻性地评估虚弱和ICU后残疾.入住疗养院(NH)和死亡之间的关系., beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7cJ6ejWUr2nIia8qOvAKNdLHr32Df6G8iaoaOx6pHaoiacwp26DaslxZHCGbibZhhCGven4rvmWP60GahtzgFjgCjR/0, createdBy=6b111703011, createdName=有备才能无患, createdTime=Sun Mar 18 23:20:34 CST 2018, time=2018-03-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=297498, encodeId=f1b829e4987e, content=阅, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/fhZdOu27e88Voqh19n8eF8cLplo8L4nicKtH0WnE3KFELXns5XDu8rsiceK2HHDZc2SEStia5VV3Pia2QLMVqlWbHw/0, createdBy=6e012139475, createdName=神功盖世, createdTime=Sun Mar 18 22:35:18 CST 2018, time=2018-03-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=297481, encodeId=90ab29e48193, content=了解一下.谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2019/12/23/2f51002e1349ccda5be11c1eea1e1e60.jpg, createdBy=a22097948, createdName=天地飞扬, createdTime=Sun Mar 18 22:24:28 CST 2018, time=2018-03-18, status=1, ipAttribution=)]
    2018-11-04 Smile2680
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    2018-03-19 衣带渐宽

    学习

    0

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    2018-03-19 owlhealth

    不错耶.学习了

    0

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    2018-03-18 有备才能无患

    虚弱是老年人易发生疾病的一个有力指标.但它与ICU结局之间的相关性尚未被前瞻性地评估(即ICU入院前获得的客观的指标).近日.呼吸领域权威杂志chest上发表了一篇研究文章.研究人员的目标是前瞻性地评估虚弱和ICU后残疾.入住疗养院(NH)和死亡之间的关系.

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    2018-03-18 神功盖世

    0

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    2018-03-18 天地飞扬

    了解一下.谢谢分享!

    0

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