BMC Pharmacol Toxicol:静脉注射葡萄糖酸钙可减轻铅引起的腹痛

2021-01-30 MedSci原创 MedSci原创

2016年,在伊朗爆发的铅中毒事件中,医生报告了数千名鸦片使用者因顽固性剧烈腹痛而到急诊科(ED)就诊,对任何麻醉药物都没有反应。近日,发表于BMC Pharmacol Toxicol的一项单中心、单

2016年,在伊朗爆发的铅中毒事件中,医生报告了数千名鸦片使用者因顽固性剧烈腹痛而到急诊科(ED)就诊,对任何麻醉药物都没有反应。近日,发表于BMC Pharmacol Toxicol的一项单中心、单盲、随机对照试验研究了静脉注射葡萄糖酸钙对缓解铅引起的腹痛的疗效,结果发现静脉注射葡萄糖酸钙配合吗啡可以改善因摄入铅污染鸦片导致铅中毒的腹痛。

研究纳入了因腹痛而到学术性急诊室就诊并初步诊断为铅中毒的成年鸦片成瘾患者,并随机接受两组治疗,分别接受常规治疗(吗啡0.1 mg/kg+生理盐水;第1组)和常规治疗加1 g静脉注射葡萄糖酸钙(第2组)以减轻他们的腹痛。每位患者在治疗前、干预后15、30、60 min分别测定视觉模拟量表(VAS)(0~100 mm)。

 

结果共纳入50名患者(每组25名)。两组患者治疗前的血铅水平、VAS评分和吗啡平均给药剂量相似。治疗后,第1组和第2组的平均VAS评分在15分钟时降至64.7±10.4 vs. 67.1±10.9(P = 0.437),30分钟时降至64.6±10.9 vs. 58.0±11.2(P = 0.041),60分钟时降至63.8±10.7 vs. 53.6±10.9(P = 0.002)。

综上所述,该研究结果表明,静脉注射葡萄糖酸钙配合吗啡可以改善因摄入铅污染鸦片导致铅中毒的腹痛。建议进一步进行干预性研究,看对疑似铅引起的腹痛的钙盐反应能否排除铅中毒。

 

原始出处:

 

Masoud Mayel, Saleh Hamzeh, et al., Intravenous calcium Gluconate alleviates Lead-induced abdominal pain, a randomized clinical trial. BMC Pharmacol Toxicol. 2020 Mar 17;21(1):23. doi: 10.1186/s40360-020-00403-8

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    2021-12-10 fusion
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GetPortalCommentsPageByObjectIdResponse(id=1272353, encodeId=780012e235342, content=<a href='/topic/show?id=c01e85565e8' target=_blank style='color:#2F92EE;'>#腹痛#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=85565, encryptionId=c01e85565e8, topicName=腹痛)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e4aa106, createdName=crystal0562, createdTime=Mon Feb 01 11:20:57 CST 2021, time=2021-02-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1492517, encodeId=db22149251ecf, content=<a href='/topic/show?id=685199141a6' target=_blank style='color:#2F92EE;'>#静脉注射#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99141, encryptionId=685199141a6, topicName=静脉注射)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=77e28942453, createdName=millore, createdTime=Mon Feb 01 11:20:57 CST 2021, time=2021-02-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=921592, encodeId=cd53921592b3, content=应该用依地酸二钠钙呀, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=9a372575911, createdName=12592a7am58暂无昵称, createdTime=Sun Jan 31 09:48:44 CST 2021, time=2021-01-31, status=1, ipAttribution=)]
  5. [GetPortalCommentsPageByObjectIdResponse(id=1975048, encodeId=bbf819e504878, content=<a href='/topic/show?id=f145355379' target=_blank style='color:#2F92EE;'>#BMC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3553, encryptionId=f145355379, topicName=BMC)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdqq.qlogo.cn/qqapp/101173734/363C99735735B7F4CB11D5F78F580525/100, createdBy=aab22500211, createdName=ms3025846204744509, createdTime=Tue Aug 03 14:20:57 CST 2021, time=2021-08-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1698191, encodeId=5dc2169819158, content=<a href='/topic/show?id=f2399910109' target=_blank style='color:#2F92EE;'>#静脉#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99101, encryptionId=f2399910109, topicName=静脉)], 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target=_blank style='color:#2F92EE;'>#MAC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11207, encryptionId=ed881120ec8, topicName=MAC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4b65161, createdName=yb6560, createdTime=Tue Feb 16 06:20:57 CST 2021, time=2021-02-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1787703, encodeId=2fdf1e87703a4, content=<a href='/topic/show?id=fa03141591e' target=_blank style='color:#2F92EE;'>#Pharm#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14159, encryptionId=fa03141591e, topicName=Pharm)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8942242, createdName=jj000001, createdTime=Mon Jul 19 23:20:57 CST 2021, time=2021-07-19, status=1, ipAttribution=), 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createdName=millore, createdTime=Mon Feb 01 11:20:57 CST 2021, time=2021-02-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=921592, encodeId=cd53921592b3, content=应该用依地酸二钠钙呀, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=9a372575911, createdName=12592a7am58暂无昵称, createdTime=Sun Jan 31 09:48:44 CST 2021, time=2021-01-31, status=1, ipAttribution=)]
  6. [GetPortalCommentsPageByObjectIdResponse(id=1975048, encodeId=bbf819e504878, content=<a href='/topic/show?id=f145355379' target=_blank style='color:#2F92EE;'>#BMC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3553, encryptionId=f145355379, topicName=BMC)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdqq.qlogo.cn/qqapp/101173734/363C99735735B7F4CB11D5F78F580525/100, createdBy=aab22500211, createdName=ms3025846204744509, createdTime=Tue Aug 03 14:20:57 CST 2021, time=2021-08-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1698191, encodeId=5dc2169819158, content=<a href='/topic/show?id=f2399910109' target=_blank style='color:#2F92EE;'>#静脉#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99101, encryptionId=f2399910109, topicName=静脉)], 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target=_blank style='color:#2F92EE;'>#MAC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11207, encryptionId=ed881120ec8, topicName=MAC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4b65161, createdName=yb6560, createdTime=Tue Feb 16 06:20:57 CST 2021, time=2021-02-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1787703, encodeId=2fdf1e87703a4, content=<a href='/topic/show?id=fa03141591e' target=_blank style='color:#2F92EE;'>#Pharm#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14159, encryptionId=fa03141591e, topicName=Pharm)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8942242, createdName=jj000001, createdTime=Mon Jul 19 23:20:57 CST 2021, time=2021-07-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1272353, encodeId=780012e235342, content=<a href='/topic/show?id=c01e85565e8' target=_blank style='color:#2F92EE;'>#腹痛#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=85565, encryptionId=c01e85565e8, topicName=腹痛)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e4aa106, createdName=crystal0562, createdTime=Mon Feb 01 11:20:57 CST 2021, time=2021-02-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1492517, encodeId=db22149251ecf, content=<a href='/topic/show?id=685199141a6' target=_blank style='color:#2F92EE;'>#静脉注射#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99141, encryptionId=685199141a6, topicName=静脉注射)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=77e28942453, createdName=millore, createdTime=Mon Feb 01 11:20:57 CST 2021, time=2021-02-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=921592, encodeId=cd53921592b3, content=应该用依地酸二钠钙呀, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=9a372575911, createdName=12592a7am58暂无昵称, createdTime=Sun Jan 31 09:48:44 CST 2021, time=2021-01-31, status=1, ipAttribution=)]
    2021-02-16 yb6560
  7. [GetPortalCommentsPageByObjectIdResponse(id=1975048, encodeId=bbf819e504878, content=<a href='/topic/show?id=f145355379' target=_blank style='color:#2F92EE;'>#BMC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3553, encryptionId=f145355379, topicName=BMC)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdqq.qlogo.cn/qqapp/101173734/363C99735735B7F4CB11D5F78F580525/100, createdBy=aab22500211, createdName=ms3025846204744509, createdTime=Tue Aug 03 14:20:57 CST 2021, time=2021-08-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1698191, encodeId=5dc2169819158, content=<a href='/topic/show?id=f2399910109' target=_blank style='color:#2F92EE;'>#静脉#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99101, encryptionId=f2399910109, topicName=静脉)], 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target=_blank style='color:#2F92EE;'>#MAC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11207, encryptionId=ed881120ec8, topicName=MAC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4b65161, createdName=yb6560, createdTime=Tue Feb 16 06:20:57 CST 2021, time=2021-02-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1787703, encodeId=2fdf1e87703a4, content=<a href='/topic/show?id=fa03141591e' target=_blank style='color:#2F92EE;'>#Pharm#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14159, encryptionId=fa03141591e, topicName=Pharm)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8942242, createdName=jj000001, createdTime=Mon Jul 19 23:20:57 CST 2021, time=2021-07-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1272353, encodeId=780012e235342, content=<a href='/topic/show?id=c01e85565e8' target=_blank style='color:#2F92EE;'>#腹痛#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=85565, encryptionId=c01e85565e8, topicName=腹痛)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e4aa106, createdName=crystal0562, createdTime=Mon Feb 01 11:20:57 CST 2021, time=2021-02-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1492517, encodeId=db22149251ecf, content=<a href='/topic/show?id=685199141a6' target=_blank style='color:#2F92EE;'>#静脉注射#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99141, encryptionId=685199141a6, topicName=静脉注射)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=77e28942453, createdName=millore, createdTime=Mon Feb 01 11:20:57 CST 2021, time=2021-02-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=921592, encodeId=cd53921592b3, content=应该用依地酸二钠钙呀, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=9a372575911, createdName=12592a7am58暂无昵称, createdTime=Sun Jan 31 09:48:44 CST 2021, time=2021-01-31, status=1, ipAttribution=)]
    2021-07-19 jj000001
  8. 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    2021-01-31 12592a7am58暂无昵称

    应该用依地酸二钠钙呀

    0

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